Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sumiyo Watanabe"'
In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers
Autor:
Sumiyo Watanabe, Kotaro Hayashi, Kazuko Toh, Hyun Jin Kim, Xueying Liu, Hiroyuki Chaya, Shigeto Fukushima, Keisuke Katsushima, Yutaka Kondo, Satoshi Uchida, Satomi Ogura, Takahiro Nomoto, Hiroyasu Takemoto, Horacio Cabral, Hiroaki Kinoh, Hiroyoshi Y. Tanaka, Mitsunobu R. Kano, Yu Matsumoto, Hiroshi Fukuhara, Shunya Uchida, Masaomi Nangaku, Kensuke Osada, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nanoparticle delivery of siRNA has problems with penetration and off target accumulation. Here, the authors report on the development of Y-shaped block catiomers which dynamically wrap around siRNA; demonstrate increased circulation times and deliver
Externí odkaz:
https://doaj.org/article/e56544229bd24572b3344d7cb418ce63
Autor:
Sumiyo Watanabe, Toru Ogasawara, Yoshifuru Tamura, Taku Saito, Toshiyuki Ikeda, Nobuchika Suzuki, Tatsuo Shimosawa, Shigeru Shibata, Ung-Il Chung, Masaomi Nangaku, Shunya Uchida
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0168638 (2017)
Although techniques for cell-specific gene expression via viral transfer have advanced, many challenges (e.g., viral vector design, transduction of genes into specific target cells) still remain. We investigated a novel, simple methodology for using
Externí odkaz:
https://doaj.org/article/db96423aac4f407480d600d333605e35
Autor:
Shunya Uchida, Tatsuru Ota, Sumiyo Watanabe, Shigeyuki Arai, Emiko Kuribayashi-Okuma, Harumi Hisaki, Shigeru Shibata, Tosifusa Toda, Tomoki Okazaki
Publikováno v:
Therapeutic Apheresis and Dialysis. 20:174-182
Low-density lipoprotein apheresis (LDL-A) has been shown to reduce proteinuria in a subgroup of nephrotic syndrome patients refractory to immunosuppressive therapy. Factors influencing the efficacy of LDL-A in nephrotic syndrome are completely unknow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77d45c9e78412594d8fc7115fcdc6020
https://doi.org/10.1111/1744-9987.12356
https://doi.org/10.1111/1744-9987.12356
Autor:
Kensuke Osada, Hiroyasu Takemoto, Kazunori Kataoka, Nobuhiro Nishiyama, Hiroyuki Chaya, Kanjiro Miyata, Kotaro Hayashi, Sumiyo Watanabe, Shigeto Fukushima
Publikováno v:
Macromolecular Rapid Communications. 37(No. 6):486-493
Polyion complexes (b-PICs) are prepared by mixing single- or double-stranded oligo RNA (aniomer) with poly(ethylene glycol)-b-poly(L-lysine) (PEG-PLL) (block catiomer) to clarify the effect of aniomer chain rigidity on association behaviors at varyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ea26d77e9d7372e19ee92b206290d2
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100720773
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100720773
In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers
Autor:
Kazuko Toh, Hiroaki Kinoh, Hiroyasu Takemoto, Mitsunobu R. Kano, Hiroshi Fukuhara, Sumiyo Watanabe, Keisuke Katsushima, Nobuhiro Nishiyama, Kotaro Hayashi, Yutaka Kondo, Hiroyuki Chaya, Satoshi Uchida, Satomi Ogura, Kanjiro Miyata, Takahiro Nomoto, Hyun Jin Kim, Horacio Cabral, Masaomi Nangaku, Kazunori Kataoka, Shigeto Fukushima, Shunya Uchida, Kensuke Osada, Xueying Liu, Yu Matsumoto, Hiroyoshi Y. Tanaka
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Stabilisation of fragile oligonucleotides, typically small interfering RNA (siRNA), is one of the most critical issues for oligonucleotide therapeutics. Many previous studies encapsulated oligonucleotides into ~100-nm nanoparticles. However, such nan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e681b4e8b335d42bea454a42055b10a
https://repo.qst.go.jp/records/77026
https://repo.qst.go.jp/records/77026
Autor:
Nobuhiro Nishiyama, Kazuko Toh, Sumiyo Watanabe, Hyun Jin Kim, Kanjiro Miyata, Yu Matsumoto, Meng Zheng, Kazunori Kataoka, Takehiko Ishii
Publikováno v:
Drug Delivery and Translational Research. 4:50-60
For systemic small interfering RNA (siRNA) delivery to tumor mass, a multifunctional polyion complex micelle was constructed with a block copolymer bearing a targeting ligand and a micelle-stabilizing moiety as well as an endosome-disrupting cationic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c76cf18bc6be6819a3c002f6289316e
https://doi.org/10.1007/s13346-013-0175-6
https://doi.org/10.1007/s13346-013-0175-6
Autor:
Kazushi Kinbara, Takuzo Aida, Sumiyo Watanabe, Kanjiro Miyata, Shuvendu Biswas, Tatsuya Niwa, Kazunori Kataoka, Hideki Taguchi, Noriyuki Ishii
Publikováno v:
Nature Chemistry. 5:613-620
The development of nanocarriers that selectively release guest molecules on sensing a particular biological signal is being actively pursued in nanomedicine for diagnostic and therapeutic purposes. Here we report a protein-based nanocarrier that open
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2931992ea2857b3a78bfa7c6be78ff45
https://doi.org/10.1038/nchem.1681
https://doi.org/10.1038/nchem.1681
Autor:
Emiko, Kuribayashi-Okuma, Shigeru, Shibata, Shigeyuki, Arai, Tatsuru, Ota, Sumiyo, Watanabe, Harumi, Hisaki, Tomoki, Okazaki, Tosifusa, Toda, Shunya, Uchida
Publikováno v:
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. 20(2)
Low-density lipoprotein apheresis (LDL-A) has been shown to reduce proteinuria in a subgroup of nephrotic syndrome patients refractory to immunosuppressive therapy. Factors influencing the efficacy of LDL-A in nephrotic syndrome are completely unknow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65d67e6493c00f78b3042d477e1a2994
https://pubmed.ncbi.nlm.nih.gov/26771065
https://pubmed.ncbi.nlm.nih.gov/26771065
Autor:
Sumiyo Watanabe, Seiji Fukumoto, Yuji Oka, Shinsuke Sasaki, Yasushi Muraosa, Noriko Chikatsu, Yasuhiro Takeuchi, Toshiro Fujita
Publikováno v:
Endocrine Journal. 50:91-96
Autosomal dominant hypocalcemia (ADH) caused by activating mutations of calcium-sensing receptor (CaSR) is characterized by hypocalcemia with inappropriately low concentration of PTH and relative hypercalciuria. Active vitamin D treatment often leads
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5383d4660dd678cec034d1930965f2a
https://doi.org/10.1507/endocrj.50.91
https://doi.org/10.1507/endocrj.50.91
Publikováno v:
The Journal of clinical endocrinology and metabolism. 99(2)
Autosomal dominant hypocalcemia (ADH) is a congenital isolated hypoparathyroidism caused by activating mutations in the calcium-sensing receptor (CASR) gene. The clinical features of ADH are heterogeneous; some patients are asymptomatic, and others s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ff52b35f541f8edb44c8a700c4f6fda
https://pubmed.ncbi.nlm.nih.gov/24297799
https://pubmed.ncbi.nlm.nih.gov/24297799