Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sumitra Sengupta"'
Autor:
Michael A. Garland, Sumitra Sengupta, Lijoy K. Mathew, Lisa Truong, Esther de Jong, Aldert H. Piersma, Jane La Du, Robert L. Tanguay
Publikováno v:
Toxicology Reports, Vol 6, Iss , Pp 529-537 (2019)
We previously used a chemical genetics approach with the larval zebrafish to identify small molecule inhibitors of tissue regeneration. This led to the discovery that glucocorticoids (GC) block early stages of tissue regeneration by the inappropriate
Externí odkaz:
https://doaj.org/article/7c87a8bbf9e045cc8a3764e044060f98
Autor:
Arife Unal Eroglu, Timothy S. Mulligan, Liyun Zhang, David T. White, Sumitra Sengupta, Cathy Nie, Noela Y. Lu, Jiang Qian, Lisha Xu, Wuhong Pei, Shawn M. Burgess, Meera T. Saxena, Jeff S. Mumm
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Thousands of genes have been implicated in retinal regeneration, but only a few have been shown to impact the regenerative capacity of Müller glia—an adult retinal stem cell with untapped therapeutic potential. Similarly, among nearly 300 genetic
Externí odkaz:
https://doaj.org/article/26f4e85cc8724161b9abfd475abe72c6
Autor:
Edmond F O'Donnell, Katerine S Saili, Daniel C Koch, Prasad R Kopparapu, David Farrer, William H Bisson, Lijoy K Mathew, Sumitra Sengupta, Nancy I Kerkvliet, Robert L Tanguay, Siva Kumar Kolluri
Publikováno v:
PLoS ONE, Vol 5, Iss 10 (2010)
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxicity and biological activity of dioxins and related chemicals. The AhR influences a variety of processes involved in cellular growth and differentiat
Externí odkaz:
https://doaj.org/article/ff6d993d8c44450790b18bd377768fa9
Autor:
Timothy Mulligan, Lisha Xu, Jiang Qian, Cathy Nie, Arife Unal Eroglu, Sumitra Sengupta, Meera T. Saxena, Noela Y. Lu, Jeff S. Mumm, Liyun Zhang, David T. White, Shawn M. Burgess, Wuhong Pei
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
Thousands of genes have been implicated in retinal regeneration, but only a few have been shown to impact the regenerative capacity of Müller glia-an adult retinal stem cell with untapped therapeutic potential. Similarly, among nearly 300 genetic lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca027f414740696605ae2d077387078
https://doi.org/10.3389/fcell.2018.00088
https://doi.org/10.3389/fcell.2018.00088
Publikováno v:
Future Medicinal Chemistry. 7:2263-2283
Regeneration involves interactions between multiple signaling pathways acting in a spatially and temporally complex manner. As signaling pathways are highly conserved, understanding how regeneration is controlled in animal models exhibiting robust re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e71e5855cbf0ca6e0d5cceaca0a6fc02
https://doi.org/10.4155/fmc.15.137
https://doi.org/10.4155/fmc.15.137
Autor:
Jeff S. Mumm, Qingguo Xu, Meera T. Saxena, David T. White, Hongkai Ji, Sumitra Sengupta, Ding Ding, Justin Hanes
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Muller glia (MG) function as inducible retinal stem cells in zebrafish, completely repairing the eye after damage. The innate immune system has recently been shown to promote tissue regeneration in which classic wound-healing responses predominate. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c468eeb3c2e3cb861eda316b7d4f44d
https://doi.org/10.1073/pnas.1617721114
https://doi.org/10.1073/pnas.1617721114
Autor:
Ding Ding, David T. White, Arife Unal Eroglu, Sumitra Sengupta, Jiang Qian, Jeff S. Mumm, Steven L. Walker, Hongkai Ji, Surendra Kumar Rajpurohit, Liyun Zhang, Guohua Wang
Publikováno v:
Nature protocols. 11(12)
The zebrafish has emerged as an important model for whole-organism small-molecule screening. However, most zebrafish-based chemical screens have achieved only mid-throughput rates. Here we describe a versatile whole-organism drug discovery platform t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62ee059ced36da0b8102d45a6b6b276
https://pubmed.ncbi.nlm.nih.gov/27831568
https://pubmed.ncbi.nlm.nih.gov/27831568
Publikováno v:
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 156:121-129
Since their characterization, glucocorticoids (GCs), the most commonly prescribed immunomodulatory drugs, have undergone numerous structural modifications designed to enhance their activity. In vivo assessment of these corticosteroid analogs is essen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8d827c37565da06c8dd54e2ca34f7f
https://doi.org/10.1016/j.cbpc.2012.05.003
https://doi.org/10.1016/j.cbpc.2012.05.003
Publikováno v:
The FASEB Journal. 22:3087-3096
Exposure to dioxins, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), causes a wide array of toxicities in vertebrates, which are mostly considered to be mediated through the inappropriate activation of the aryl hydrocarbon receptor (AHR) signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41443eae80483143d79a70735693e844
https://doi.org/10.1096/fj.08-109009
https://doi.org/10.1096/fj.08-109009
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:5750-5758
A series of organoselenocyanate compounds 4a-d were synthesized utilizing 1,8-naphthalic anhydride as the building unit. These compounds were evaluated for their antioxidative activities against DMBA-PMA-induced oxidative stress in a two-stage mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c38a6201978adb6da2c9f9dd43390d
https://doi.org/10.1016/j.bmc.2005.06.011
https://doi.org/10.1016/j.bmc.2005.06.011