Výsledky vyhledávání - "Sumith K, Mathew"

Akademický článek

Genetic predisposition and high exposure to colistin in the early treatment period as independent risk factors for colistin‐induced nephrotoxicity

Autor: Sumith K. Mathew, Aaron Chapla, Padmanaban Venkatesan, Vishnu Eriyat, Blessed Winston Aruldhas, Ratna Prabha, Michael N. Neely, Shoma V. Rao, Subramani Kandasamy, Binu Susan Mathew

Publikováno v: Clinical and Translational Science, Vol 17, Iss 3, Pp n/a-n/a (2024)

Abstract Colistin is known to cause nephrotoxicity due to its extensive reabsorption and accumulation in renal tubules. In vitro studies have identified the functional role of colistin transporters such as OCTN2, PEPT2, megalin, and P‐glycoprotein.

Externí odkaz: https://doaj.org/article/9ea553ee2bef42678402da034fde1eb8

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Akademický článek

Cefepime Daily Exposure and the Associated Impact on the Change in Sequential Organ Failure Assessment Scores and Vasopressors Requirement in Critically Ill Patients Using Repeated-Measures Mixed-Effect Modeling

Autor: Mohammad H. Alshaer, PharmD, PhD, Roy Williams, MPH, Mays J. Mousa, PharmD, MBA, Kaitlin M. Alexander, PharmD, Kelly L. Maguigan, PharmD, Kayihura Manigaba, PharmD, Nicole Maranchick, PharmD, Bethany R. Shoulders, PharmD, Timothy W. Felton, MBBS, PhD, Sumith K. Mathew, MD, Charles A. Peloquin, PharmD

Publikováno v: Critical Care Explorations, Vol 5, Iss 11, p e0993 (2023)

IMPORTANCE:. Sepsis and septic shock are major healthcare problems that need early and appropriate management. OBJECTIVES:. To evaluate the association of daily cefepime pharmacokinetic/pharmacodynamic (PK/PD) parameters with change in Sequential Org

Externí odkaz: https://doaj.org/article/5bf159a8cfa740ee8799b467d4b4c8cf

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Identification of DPYD variants and estimation of uracil and dihydrouracil in a healthy Indian population

Autor: Poornima Sivamani, Vishnu Eriyat, Sumith K Mathew, Ashish Singh, Rekha Aaron, Raju Titus Chacko, Anjana Joel, Ratna Prabha, Binu Susan Mathew

Publikováno v: Personalized Medicine. 20:39-53

Aim: This study aimed to identify DPYD variants and the related but previously unexplored phenotype (plasma uracil, dihydrouracil [DHU], and the DHU-to-uracil ratio) in a healthy adult Indian population. Methods: Healthy adult volunteers (n = 100) ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e61d5c30747292937a0692dc52fa5dd6
https://doi.org/10.2217/pme-2022-0042

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Analytical and clinical validation of dried blood spot and volumetric absorptive microsampling for measurement of tacrolimus and creatinine after renal transplantation

Autor: Binu Susan Mathew, Sumith K. Mathew, Blessed Winston Aruldhas, Ratna Prabha, Naveen Gangadharan, Vinoi George David, Santosh Varughese, George Tharayil John

Publikováno v: Clinical Biochemistry. :25-34

Serial monitoring of tacrolimus and serum creatinine after renal transplantation is of vital importance. In this study, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for the estimation of tacrolimus and creatinine, obtained from d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b017a50cd0734dd7def3b3a8900497e
https://doi.org/10.1016/j.clinbiochem.2022.04.014

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Exposure to Azathioprine Metabolites and Clinical Outcome in Indian Patients with Crohn’s Disease

Autor: Ratna Prabha, Sumith K. Mathew, A. J. Joseph, Binu Susan Mathew

Publikováno v: Journal of Pharmacology and Pharmacotherapeutics. 13:266-271

Aim: To determine the concentration of 6-thioguanine nucleotide (6-TGN) and 6-methylmercaptopurine (6-MMP), the interpatient variability, and the relationship with disease activity in patients with Chron’s disease on long-term stable doses of azath

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8849152a2a3429522f3203fd820f413a
https://doi.org/10.1177/0976500x221085804

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Efficacy of Crushed Delayed-Release Posaconazole Tablets in Rhino-Orbito-Cerebral Mucormycosis

Autor: Abi Manesh, Emily Devasagayam, Kundakarla Bhanuprasad, Sumith K. Mathew, Rajiv Karthik, Binu S. Mathew, George M. Varghese

Publikováno v: Antimicrob Agents Chemother

A significant proportion of patients with Rhino-orbito-cerebral mucormycosis (ROCM) develop oroantral fistulas. Due to the unclear efficacy of crushed delayed-release posaconazole tablets (DRPT) via nasogastric tube in this group of patients, clinici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa763cd76a3cd643c10607ebebede7c
https://europepmc.org/articles/PMC9765161/

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Using Machine Learning To Define the Impact of Beta-Lactam Early and Cumulative Target Attainment on Outcomes in Intensive Care Unit Patients with Hospital-Acquired and Ventilator-Associated Pneumonia

Autor: Mohammad H. Alshaer, Nicole Maranchick, Chen Bai, Kelly L. Maguigan, Bethany Shoulders, Timothy W. Felton, Sumith K. Mathew, Mamoun T. Mardini, Charles A. Peloquin

Publikováno v: Antimicrob Agents Chemother

Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are the most common intensive care unit (ICU) infections. We aimed to evaluate the association of early and cumulative beta-lactam pharmacokinetic/pharmacodynamic (PK/PD) par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197d4d4b1fdf1b60c020f135b7bb8a71
https://doi.org/10.1128/aac.00563-22

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Systemic exposure to 5‐fluorouracil and its metabolite, 5,6‐dihydrofluorouracil, and development of a limited sampling strategy for therapeutic drug management of 5‐fluorouracil in patients with gastrointestinal malignancy

Autor: Ratna Prabha, Ashish Singh, Binu S. Mathew, Blessed Winston Aruldhas, Raju Titus Chacko, Jeana Jacob, Sumith K Mathew

Publikováno v: British Journal of Clinical Pharmacology. 87:937-945

Aims 5-Fluorouracil (5-FU) is widely used in combination chemotherapy, and literature suggests pharmacokinetic-guided dosing to improve clinical efficacy and reduce toxicity. This study aimed to determine the pharmacokinetic exposure of both 5-FU and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269e077258aa09762b1ccae46ec984d4
https://doi.org/10.1111/bcp.14444

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Model-Informed Rationale for Early Therapeutic Drug Monitoring of Colistin in Critically Ill Patients

Autor: Sumith K. Mathew, Shoma V. Rao, Ratna Prabha, Michael N. Neely, Binu Susan Mathew, Blessed Winston Aruldhas, Balaji Veeraraghavan, Subramani Kandasamy

Publikováno v: Journal of clinical pharmacologyReferences.

Adequate colistin exposure is important for microbiological clearance. This study was performed in critically ill patients18 years old to develop a simplified nonparametric pharmacokinetic (PK) model of colistin for routine clinical use and to determ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b90a3206f828d83393963064a8b733
https://pubmed.ncbi.nlm.nih.gov/35924629

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