Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Sumit Kumar, Hira"'
Autor:
Aiindrila Dhara, Imlimaong Aier, Ankush Paladhi, Pritish Kumar Varadwaj, Sumit Kumar Hira, Nirmalya Sen
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
PGC1α acts as a co-activator of the ERG transcription factor during metabolic stress resulting in antioxidant functionsand inhibition of the PGC1α-ERG driven transcriptional program reduces prostate cancer growth by inducing ROS mediated apoptosis.
Externí odkaz:
https://doaj.org/article/d3f473805ae74ccda131fd09b6535e77
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
T-cell exhaustion plays a pivotal role in the resistance of microsatellite-stable colorectal cancer (CRC) to immunotherapy. Identifying and targeting T-cell exhaustion-activating mechanisms is a promising strategy to augment the effects of immunother
Externí odkaz:
https://doaj.org/article/3d44d3f1d7b14c2ea0c0150c5d410e77
Autor:
Ankush Paladhi, Abhinandan Rej, Debanjan Sarkar, Ranjeet Singh, Sankar Bhattacharyya, Prasanta Kumar Sarkar, Pulak Kanti Kar, Partha Pratim Manna, Sumit Kumar Hira
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Integrative medicine practices, such as Ayurveda, are popular in India and many South Asian countries, yet basic research to investigate the concepts, procedures, and medical benefits of ayurvedic products has received little attention and is not ful
Externí odkaz:
https://doaj.org/article/7ee93d7f55b64504b8c27bc03cde787c
Autor:
Sumit Kumar Hira, Abhinandan Rej, Ankush Paladhi, Ranjeet Singh, Jayasree Saha, Indrani Mondal, Sankar Bhattacharyya, Partha Pratim Manna
Publikováno v:
iScience, Vol 23, Iss 10, Pp 101623- (2020)
Summary: Galunisertib (LY2157299) is a selective ATP-mimetic inhibitor of TGF-β receptor-I activation, currently under clinical trial in a variety of cancers. We have tested the combined effects of galunisertib- and interleukin-15-activated dendriti
Externí odkaz:
https://doaj.org/article/36225434a4cb41d3b14d836c02dc660f
Autor:
Ranjeet Singh, Uttam Gupta, Prateek Srivastava, Ankush Paladhi, Ugir Hossain Sk, Sumit Kumar Hira, Partha Pratim Manna
Publikováno v:
Cytotherapy. 24:1232-1244
The stimulatory natural killer-dendritic cell axis in the tumor microenvironment could play a critical role in stimulating cytotoxic T cells and driving immune responses against cancer.We established a novel treatment protocol by adroitly combining c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c6ba32791817ca94b95df0b8c9229b
https://doi.org/10.1016/j.jcyt.2022.07.012
https://doi.org/10.1016/j.jcyt.2022.07.012
Publikováno v:
Boletín de la Sociedad Española de Cerámica y Vidrio. 61:64-75
Zirconia and silver oxide substituted 1393 bioactive glasses (1393Zr and 1393Zr–1Ag) were prepared by sol-gel technique and sintered at 900–1100 °C. ZrO2 incorporation into the glass was on the sole purpose of mechanical performance augmentation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d26099de8f38649b1312bc99d13ba62
https://doi.org/10.1016/j.bsecv.2020.07.002
https://doi.org/10.1016/j.bsecv.2020.07.002
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 40:10578-10591
Despite several extensive and exhaustive efforts, search for potential therapy against leishmaniasis has not made much progress. In the present work, we have employed mining strategy to screen Leishmania donovani proteome for identification of promis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::959bee1070cbe5e310657d88ac3a5f20
https://doi.org/10.1080/07391102.2021.1945495
https://doi.org/10.1080/07391102.2021.1945495
Autor:
Abhinandan Rej, Ankush Paladhi, Samrat Daripa, Debanjan Sarkar, Sankar Bhattacharyya, Indrani Mondal, Sumit Kumar Hira
Publikováno v:
International immunopharmacology. 114
In clinical practice, major efforts are underway to identify appropriate drug combinations to boost anticancer activity while suppressing unwanted adverse effects. In this regard, we evaluated the efficacy of combination treatment with the widely use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a26a8d7d01186fbdaf8d07321da4cc
https://pubmed.ncbi.nlm.nih.gov/36470118
https://pubmed.ncbi.nlm.nih.gov/36470118
Autor:
Divesh N. Srivastava, Sumit Kumar Hira, Prateek Srivastava, Ranjeet Singh, Ram Adhar Singh, Partha Pratim Manna, Ankush Paladhi
Publikováno v:
Molecular Pharmaceutics. 18:2053-2065
We fabricated bilirubin-bovine serum albumin (BR-BSA) nanocomplexes as candidates for the delivery of 5-fluoro-2-deoxyuridine (5FUdr) against experimental murine lymphoma. BR was attached to 5FUdr via acid-labile ester bonds mimicking small-molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cff62a5b7fe5c62b22522258c97c4d37
https://doi.org/10.1021/acs.molpharmaceut.1c00050
https://doi.org/10.1021/acs.molpharmaceut.1c00050
Autor:
Sumit Kumar Hira, Ugir Hossain Sk, Abhinandan Rej, Debapriya RoyMahapatra, Partha Pratim Manna
Publikováno v:
ACS Applied Bio Materials. 4:2628-2638
Enhanced drug localization at the tumor sites with minimal toxicity was demonstrated using dendrimer-conjugated temozolomide for treating experimental lymphoma, developed as a solid tumor. Herein, we have constructed a polyamidoamine (PAMAM) dendrime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963f1312b25e3f564d6e8ccfd35ae95a
https://doi.org/10.1021/acsabm.0c01599
https://doi.org/10.1021/acsabm.0c01599