Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Sumit K Chanda"'
Autor:
Kuoyuan Cheng, Laura Martin‐Sancho, Lipika R Pal, Yuan Pu, Laura Riva, Xin Yin, Sanju Sinha, Nishanth Ulhas Nair, Sumit K Chanda, Eytan Ruppin
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 11, Pp 1-19 (2021)
Abstract Tremendous progress has been made to control the COVID‐19 pandemic caused by the SARS‐CoV‐2 virus. However, effective therapeutic options are still rare. Drug repurposing and combination represent practical strategies to address this u
Externí odkaz:
https://doaj.org/article/7f7daa898bfc42e18657f5c1309d7466
Autor:
Pinar Mesci, Janaina S de Souza, Laura Martin-Sancho, Angela Macia, Aurian Saleh, Xin Yin, Cedric Snethlage, Jason W Adams, Simoni H Avansini, Roberto H Herai, Angels Almenar-Queralt, Yuan Pu, Ryan A Szeto, Gabriela Goldberg, Patrick T Bruck, Fabio Papes, Sumit K Chanda, Alysson R Muotri
Publikováno v:
PLoS Biology, Vol 20, Iss 11, p e3001845 (2022)
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which was rapidly declared a pandemic by the World Health Organization (WHO). Early clinical symptomatology focused mainly
Externí odkaz:
https://doaj.org/article/6aa0ab0984624ab78fd93b16b7af8954
Autor:
Charlotte A Stoneham, Simon Langer, Paul D De Jesus, Jacob M Wozniak, John Lapek, Thomas Deerinck, Andrea Thor, Lars Pache, Sumit K Chanda, David J Gonzalez, Mark Ellisman, John Guatelli
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11, p e1009409 (2021)
The HIV-1 accessory protein Vpu modulates membrane protein trafficking and degradation to provide evasion of immune surveillance. Targets of Vpu include CD4, HLAs, and BST-2. Several cellular pathways co-opted by Vpu have been identified, but the pic
Externí odkaz:
https://doaj.org/article/2522facbcf89469cb6071b09673a1333
Autor:
Simon Langer, Christian Hammer, Kristina Hopfensperger, Lukas Klein, Dominik Hotter, Paul D De Jesus, Kristina M Herbert, Lars Pache, Nikaïa Smith, Johannes A van der Merwe, Sumit K Chanda, Jacques Fellay, Frank Kirchhoff, Daniel Sauter
Publikováno v:
eLife, Vol 8 (2019)
Many viral pathogens target innate sensing cascades and/or cellular transcription factors to suppress antiviral immune responses. Here, we show that the accessory viral protein U (Vpu) of HIV-1 exerts broad immunosuppressive effects by inhibiting act
Externí odkaz:
https://doaj.org/article/31d02328d8d0423daf368955ad8e0294
Autor:
Mark E. Becker, Laura Martin-Sancho, Lacy M. Simons, Michael D. McRaven, Sumit K. Chanda, Judd F. Hultquist, Thomas J. Hope
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract SARS-CoV-2 initiates infection in the conducting airways, where mucociliary clearance inhibits pathogen penetration. However, it is unclear how mucociliary clearance impacts SARS-CoV-2 spread after infection is established. To investigate vi
Externí odkaz:
https://doaj.org/article/d1189d67a80f4aab97f5f561dc48a2af
Autor:
Dorothea Emig-Agius, Kevin Olivieri, Lars Pache, Hsin Ling Shih, Olga Pustovalova, Marina Bessarabova, John A T Young, Sumit K Chanda, Trey Ideker
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96687 (2014)
Recent proteomic and genetic studies have aimed to identify a complete network of interactions between HIV and human proteins and genes. This HIV-human interaction network provides invaluable information as to how HIV exploits the host machinery and
Externí odkaz:
https://doaj.org/article/f29cbe97aeba42728eb5a4c5791daa8b
Autor:
Amanda M Opaluch, Monika Schneider, Chih-yuan Chiang, Quy T Nguyen, Ana M Maestre, Lubbertus C F Mulder, Ismael Secundino, Paul D De Jesus, Renate König, Viviana Simon, Victor Nizet, Graham MacLeod, Susannah Varmuza, Ana Fernandez-Sesma, Sumit K Chanda
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89284 (2014)
Innate immune sensors such as Toll-like receptors (TLRs) differentially utilize adaptor proteins and additional molecular mediators to ensure robust and precise immune responses to pathogen challenge. Through a gain-of-function genetic screen, we ide
Externí odkaz:
https://doaj.org/article/8a1d8360ade647799e0b14344a763138
Autor:
Hao Chen, Frederick J. King, Bin Zhou, Yu Wang, Carter J. Canedy, Joel Hayashi, Yang Zhong, Max W. Chang, Lars Pache, Julian L. Wong, Yong Jia, John Joslin, Tao Jiang, Christopher Benner, Sumit K. Chanda, Yingyao Zhou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Many machine learning applications in bioinformatics currently rely on matching gene identities when analyzing input gene signatures and fail to take advantage of preexisting knowledge about gene functions. To further enable comparative anal
Externí odkaz:
https://doaj.org/article/3b4f238e44764f15bb18667e531420c4
Autor:
Karen E Ocwieja, Troy L Brady, Keshet Ronen, Alyssa Huegel, Shoshannah L Roth, Torsten Schaller, Leo C James, Greg J Towers, John A T Young, Sumit K Chanda, Renate König, Nirav Malani, Charles C Berry, Frederic D Bushman
Publikováno v:
PLoS Pathogens, Vol 7, Iss 3, p e1001313 (2011)
Genome-wide siRNA screens have identified host cell factors important for efficient HIV infection, among which are nuclear pore proteins such as RanBP2/Nup358 and the karyopherin Transportin-3/TNPO3. Analysis of the roles of these proteins in the HIV
Externí odkaz:
https://doaj.org/article/f25183735b154f4b95512dccdb88946b
Autor:
Yixuan Chen, Wenhui Wang, Yingyao Zhou, Robert Shields, Sumit K Chanda, Robert C Elston, Jing Li
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21137 (2011)
Identifying disease genes is crucial to the understanding of disease pathogenesis, and to the improvement of disease diagnosis and treatment. In recent years, many researchers have proposed approaches to prioritize candidate genes by considering the
Externí odkaz:
https://doaj.org/article/5c4d69caf8604ed482ed02ae2c8e1bcc