Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Sumit K, Chanda"'
Autor:
Mark E. Becker, Laura Martin-Sancho, Lacy M. Simons, Michael D. McRaven, Sumit K. Chanda, Judd F. Hultquist, Thomas J. Hope
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract SARS-CoV-2 initiates infection in the conducting airways, where mucociliary clearance inhibits pathogen penetration. However, it is unclear how mucociliary clearance impacts SARS-CoV-2 spread after infection is established. To investigate vi
Externí odkaz:
https://doaj.org/article/d1189d67a80f4aab97f5f561dc48a2af
Autor:
Hao Chen, Frederick J. King, Bin Zhou, Yu Wang, Carter J. Canedy, Joel Hayashi, Yang Zhong, Max W. Chang, Lars Pache, Julian L. Wong, Yong Jia, John Joslin, Tao Jiang, Christopher Benner, Sumit K. Chanda, Yingyao Zhou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Many machine learning applications in bioinformatics currently rely on matching gene identities when analyzing input gene signatures and fail to take advantage of preexisting knowledge about gene functions. To further enable comparative anal
Externí odkaz:
https://doaj.org/article/3b4f238e44764f15bb18667e531420c4
Autor:
Kelsey M. Haas, Michael J. McGregor, Mehdi Bouhaddou, Benjamin J. Polacco, Eun-Young Kim, Thong T. Nguyen, Billy W. Newton, Matthew Urbanowski, Heejin Kim, Michael A. P. Williams, Veronica V. Rezelj, Alexandra Hardy, Andrea Fossati, Erica J. Stevenson, Ellie Sukerman, Tiffany Kim, Sudhir Penugonda, Elena Moreno, Hannes Braberg, Yuan Zhou, Giorgi Metreveli, Bhavya Harjai, Tia A. Tummino, James E. Melnyk, Margaret Soucheray, Jyoti Batra, Lars Pache, Laura Martin-Sancho, Jared Carlson-Stevermer, Alexander S. Jureka, Christopher F. Basler, Kevan M. Shokat, Brian K. Shoichet, Leah P. Shriver, Jeffrey R. Johnson, Megan L. Shaw, Sumit K. Chanda, Dan M. Roden, Tonia C. Carter, Leah C. Kottyan, Rex L. Chisholm, Jennifer A. Pacheco, Maureen E. Smith, Steven J. Schrodi, Randy A. Albrecht, Marco Vignuzzi, Lorena Zuliani-Alvarez, Danielle L. Swaney, Manon Eckhardt, Steven M. Wolinsky, Kris M. White, Judd F. Hultquist, Robyn M. Kaake, Adolfo García-Sastre, Nevan J. Krogan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-27 (2023)
Abstract Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of antiviral therapies. Understanding host proteins essential for IAV infection can identify targets for alternative host-directed therapies (HDTs). Using aff
Externí odkaz:
https://doaj.org/article/6403bbe7a8b6480aacd27d46627e36f2
Autor:
Daniel Madriz Sørensen, Christian Büll, Thomas D. Madsen, Erandi Lira-Navarrete, Thomas Mandel Clausen, Alex E. Clark, Aaron F. Garretson, Richard Karlsson, Johan F. A. Pijnenborg, Xin Yin, Rebecca L. Miller, Sumit K. Chanda, Thomas J. Boltje, Katrine T. Schjoldager, Sergey Y. Vakhrushev, Adnan Halim, Jeffrey D. Esko, Aaron F. Carlin, Ramon Hurtado-Guerrero, Roberto Weigert, Henrik Clausen, Yoshiki Narimatsu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Here, the authors discover small molecules that inhibit glycosylation processes that occur in the Golgi apparatus of cells. The molecules reversibly inhibit formation of elaborate glycan structures without affecting secretion of glycoproteins.
Externí odkaz:
https://doaj.org/article/6c4688dc07fc45e1bcff09858f02a146
Publikováno v:
Viruses, Vol 15, Iss 12, p 2435 (2023)
Antiretroviral therapy (ART) has brought the HIV/AIDS epidemic under control, but a curative strategy for viral eradication is still needed. The cessation of ART results in rapid viral rebound from latently infected CD4+ T cells, showing that control
Externí odkaz:
https://doaj.org/article/db54a03a762241cfa2cb35d3addad8e1
Autor:
Kuoyuan Cheng, Laura Martin‐Sancho, Lipika R Pal, Yuan Pu, Laura Riva, Xin Yin, Sanju Sinha, Nishanth Ulhas Nair, Sumit K Chanda, Eytan Ruppin
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 11, Pp 1-19 (2021)
Abstract Tremendous progress has been made to control the COVID‐19 pandemic caused by the SARS‐CoV‐2 virus. However, effective therapeutic options are still rare. Drug repurposing and combination represent practical strategies to address this u
Externí odkaz:
https://doaj.org/article/7f7daa898bfc42e18657f5c1309d7466
Autor:
Pinar Mesci, Janaina S. de Souza, Laura Martin-Sancho, Angela Macia, Aurian Saleh, Xin Yin, Cedric Snethlage, Jason W. Adams, Simoni H. Avansini, Roberto H. Herai, Angels Almenar-Queralt, Yuan Pu, Ryan A. Szeto, Gabriela Goldberg, Patrick T. Bruck, Fabio Papes, Sumit K. Chanda, Alysson R. Muotri
Publikováno v:
PLoS Biology, Vol 20, Iss 11 (2022)
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which was rapidly declared a pandemic by the World Health Organization (WHO). Early clinical symptomatology focused mainly
Externí odkaz:
https://doaj.org/article/d270539d16b945478c694db07d712953
Autor:
Lipika R. Pal, Kuoyuan Cheng, Nishanth Ulhas Nair, Laura Martin-Sancho, Sanju Sinha, Yuan Pu, Laura Riva, Xin Yin, Fiorella Schischlik, Joo Sang Lee, Sumit K. Chanda, Eytan Ruppin
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104311- (2022)
Summary: Novel strategies are needed to identify drug targets and treatments for the COVID-19 pandemic. The altered gene expression of virus-infected host cells provides an opportunity to specifically inhibit viral propagation via targeting the synth
Externí odkaz:
https://doaj.org/article/38f812d912a2472cacf9acc270fddacc
Autor:
Kathryn W. Juchem, Anshu P. Gounder, Jian Ping Gao, Elise Seccareccia, Narayana Yeddula, Nicholas J. Huffmaster, Alexandra Côté-Martin, Steven E. Fogal, Donald Souza, Sarah Sirui Wang, Elizabeth R. A. Glynn, Ivy Yung, Julie Ritchie, Li Li, Jie Zheng, M. Lamine Mbow, Jun Li, Sumit K. Chanda
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
NFAT activating protein with ITAM motif 1 (NFAM1) is an ITAM bearing-transmembrane receptor that has been reported to play a role in B cell signaling and development. We performed expression analysis of NFAM1 using publicly available gene expression
Externí odkaz:
https://doaj.org/article/2f3f4e6c77ec4d86beb354c5637d3437
Autor:
Patrick J. Madden, Muhammad S. Arif, Mark E. Becker, Michael D. McRaven, Ann M. Carias, Ramon Lorenzo-Redondo, Sixia Xiao, Cecily C. Midkiff, Robert V. Blair, Elizabeth Lake Potter, Laura Martin-Sancho, Alan Dodson, Elena Martinelli, John-Paul M. Todd, Francois J. Villinger, Sumit K. Chanda, Pyone Pyone Aye, Chad J. Roy, Mario Roederer, Mark G. Lewis, Ronald S. Veazey, Thomas J. Hope
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Infection with the novel coronavirus, SARS-CoV-2, results in pneumonia and other respiratory symptoms as well as pathologies at diverse anatomical sites. An outstanding question is whether these diverse pathologies are due to replication of the virus
Externí odkaz:
https://doaj.org/article/74bcab5e177646ac8a31e5c09bd2f86c