Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sumiko Tayama"'
Publikováno v:
Archives of Toxicology. 83:69-80
The amphetamine-derived designer drugs have been illegally used worldwide as recreational drugs, some of which are known to be hepatotoxic in humans. To compare their cytotoxic effects, 3,4-methylenedioxy-N-methamphetamine (MDMA) and its related anal
Autor:
Yoshio Nakagawa, Sumiko Tayama
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 498:117-127
We investigated whether propyl gallate (PG) can induce sister-chromatid exchanges (SCEs) and chromosomal aberrations (CAs) in CHO-K1 cells. In the absence of an exogeneous metabolizing system, treatments with 0.25-1.5mM PG in plugged flasks for 3h re
Autor:
Sumiko Tayama, Yoshio Nakagawa
Publikováno v:
Archives of Toxicology. 74:99-105
The relation between the metabolism and the cytotoxic effects of bisphenol A (BPA, 2,2-bis(4-hydroxyphenyl)propane) has been studied in freshly isolated rat hepatocytes and isolated hepatic mitochondria. The incubation of hepatocytes with BPA (0.25-1
Autor:
Yoshio Nakagawa, Sumiko Tayama
Publikováno v:
Mutation Research Letters. 324:121-131
Phenylhydroquinone (PHQ), a metabolite of o-phenylphenol (OPP), is easily autoxidized to phenylbenzoquinone (PBQ) via the semiquinone (phenylsemiquinone, PSQ) with concomitant production of superoxide anion radicals (O2-.). We have used scavengers of
Autor:
Yoshio Nakagawa, Sumiko Tayama
Publikováno v:
Mutation Research/Genetic Toxicology. 259:1-12
The effects of cysteine and reduced glutathione (GSH) on the genotoxicity of o-phenylphenol (OPP) and its metabolites, phenylhydroquinone (PHQ) and phenylbenzoquinone (PBQ), were examined using the frequency of sister-chromatid exchanges (SCEs) and c
Publikováno v:
Mutation research. 649(1-2)
Some environmental estrogen-like compounds, such as bisphenol A (BPA), 4-nonylphenol (NP), 4-octylphenol (OP), propyl p-hydroxybenzoate (P-PHBA), and butyl p-hydroxybenzoate (B-PHBA), synthetic estrogen, diethylstilbestrol (DES), and natural estrogen
Publikováno v:
Chemico-biological interactions. 164(1-2)
The relationship between cytotoxicity induced by N -nitrosofenfluramine and mitochondrial or glycolytic adenosine triphosphate (ATP) synthesis-dependent intracellular bioenergetics was studied in isolated rat hepatocytes. The supplementation of fruct
Publikováno v:
Toxicology. 156(1)
The metabolism and cytotoxicity of benzophenone and estrogenic activity of its metabolites have been studied in freshly isolated rat hepatocytes and cultured MCF-7 human breast cancer cells, respectively. The incubation of hepatocytes with benzopheno
Autor:
Sumiko Tayama
Publikováno v:
Mutation research. 368(3-4)
Recently, hepatocarcinogenicity in rats and mice was reported with regard to the methylenedioxyphenyl compound, piperonyl butoxide (PB), which is used as a synergist for pyrethrins and related insecticides. Induction of sister-chromatid exchanges (SC
Publikováno v:
Biochemical pharmacology. 43(7)
The relationship between the metabolism and the cytotoxicity of ortho-phenylphenol (OPP) was investigated using isolated rat hepatocytes. Addition of OPP (0.5–1.0 mM) to the hepatocytes caused a dose-dependent toxicity; 1.0 mM OPP caused acute cell