Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sumiko Shingo"'
Publikováno v:
Current Medical Research and Opinion. 21:141-149
To compare the analgesic effect of single doses of etoricoxib 120 mg, oxycodone/ acetaminophen 10 mg/650 mg and codeine/ acetaminophen 60 mg/600 mg in acute pain using the dental impaction model.In this randomized, double-blind, placebo-controlled, p
Autor:
Jennifer Ng, Sean P. Curtis, Calogera L. McCormick, Qinfen Yu, Alise S. Reicin, G. Bergman, Sumiko Shingo
Publikováno v:
Clinical Therapeutics. 26:70-83
Background: Based on the experience with selective cyclooxygenase (COX)-2 inhibitors, including rofecoxib, valdecoxib, and celecoxib, it was anticipated that etoricoxib, a new selective COX-2 inhibitor, would display mechanism-based, dose-dependent r
Publikováno v:
Drug Information Journal. 36:501-508
Current asthma treatment guidelines recommend a reduction in inhaled corticosteroid (ICS) doses when appropriate. However, no standardized taper protocols are available to guide ICS tapering in clinical trials or in general practice. This study was d
A placebo-controlled, dose-ranging study of montelukast, a cysteinyl leukotriene–receptor antagonist
Autor:
Zev M. Munk, James M. Seltzer, Leonard C. Altman, Sumiko Shingo, Nancy Noonan, Theodore F. Reiss, Ji Zhang
Publikováno v:
Journal of Allergy and Clinical Immunology. 102:50-56
Background: The cysteinyl leukotrienes are important mediators of bronchial asthma. The clinical effect of montelukast, a potent cysteinyl leukotriene–receptor antagonist, was investigated in a randomized, placebo-controlled, multicenter, parallel-
Autor:
Beth Friedman, Aimee Dallob, Sumiko Shingo, Charles Lin, Anne Van Hecken, Inge De Lepeleire, Wesley Tanaka, Paul J. De Schepper, Arturo Porras, Marken Depré
Publikováno v:
Clinical Pharmacology and Therapeutics. 56:22-30
The pharmacodynamics, kinetics, and tolerability of a new orally active 5-lipoxygenase inhibitor were evaluated in healthy male volunteers. MK-0591, 50, 125, and 250 mg every morning and 250 mg every 12 hours, was administered for 10 days. Leukotrien
Autor:
M Gail Murphy, Daria Ewanik, Barry J Gertz, Sumiko Shingo, Howard Mertz, John H. Walsh, Thomas O. Kovacs, Bozena Sytnik, Juinn H Lin
Publikováno v:
Clinical Pharmacology and Therapeutics. 54:533-539
We investigated the effect of a novel gastrin—cholecystokinin-B receptor antagonist, L-365,260 [(3R)-3(N′-3-methylphenyl)ureido)-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one], on gastric acid secretion in humans. In a double-blind, four-period
Autor:
Kenneth C. Lasseter, Sumiko Shingo, E. Cooper Shamblen, Oscar L. Laskin, Patricia M. Patterson
Publikováno v:
The Journal of Clinical Pharmacology. 33:636-639
The dose-response relationship of oral famotidine at doses up to 10 mg was evaluated in 10 healthy male subjects to assess the extent and duration of inhibition of meal-stimulated intragastric acid secretion. Each subject received single oral adminis
Autor:
Thorir D. Bjornsson, Joyce A. Conwy, Reynold Spector, Sumiko Shingo, Richard J. Fruncillo, Sherry D. Holland, Jacqueline B. McCrea
Publikováno v:
The Journal of Clinical Pharmacology. 33:581-585
In 15 non-diabetic Type II hypercholesterolemic patients, the effect of 80 mg lovastatin daily on oral glucose tolerance was investigated. Using a randomized, double-blind, two-panel, parallel design, patients on a low cholesterol diet received lovas
Autor:
Marina Desmet, Sumiko Shingo, Thomas H. Rossing, Jennifer A. Teahan, W. Schandevyl, Ji Zhang, Theodore F. Reiss, Alain G. Dupont, Rene Verbesselt, Nicole Impens
Publikováno v:
The American review of respiratory disease. 147(6 Pt 1)
Descriptive studies suggest an association between the release of the cysteinyl leukotrienes and clinical asthma. To help clarify this association, we tested the hypothesis that an intravenous infusion of a potent and specific investigational LTD4 re
Publikováno v:
The Journal of Pain. 5:S80