Výsledky vyhledávání - "Sumiko Hamamoto"

Dietary restriction preserves the mass and function of pancreatic β cells via cell kinetic regulation and suppression of oxidative/ER stress in diabetic mice

Autor: Yukiko Kanda, Koji Nakashima, Kohei Kaku, Tomohiko Kimura, Sumiko Hamamoto, Masashi Shimoda, Mitsuru Hashiramoto, Kazuhito Tawaramoto, Hidenori Hirukawa

Publikováno v: The Journal of Nutritional Biochemistry. 26:219-226

To assess the molecular mechanisms by which dietary restriction preserves the β-cell mass and function in diabetic db/db mice. Male db/db mice were divided into two groups with or without diet restriction. Daily food intake of db/db mice was adjuste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51392ed1b21d6540c7048916af00a1e8
https://doi.org/10.1016/j.jnutbio.2014.10.007

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Anti-hypertensive azelnidipine preserves insulin signaling and glucose uptake against oxidative stress in 3T3-L1 adipocytes

Autor: Masafumi Matsuda, Kohei Kaku, Masashi Shimoda, Shinji Kamei, Yukiko Kanda-Kimura, Fuminori Tatsumi, Atsushi Obata, Sumiko Hamamoto, Tomoatsu Mune, Tomohiko Kimura, Mitsuru Hashiramoto, Hideaki Kaneto, Kazuhito Tawaramoto

Publikováno v: Endocrine Journal. 62:741-747

It is known that reactive oxygen species (ROS) are involved in the development of insulin resistance as well as pancreatic β-cell dysfunction both of which are often observed in type 2 diabetes. In this study, we evaluated the effects of azelnidipin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40997871bc62292cba804090fa3d44a
https://doi.org/10.1507/endocrj.ej15-0273

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Molecular mechanism by which pioglitazone preserves pancreatic β-cells in obese diabetic mice: evidence for acute and chronic actions as a PPARγ agonist

Autor: Koji Nakashima, Kohei Kaku, Sumiko Hamamoto, Yukiko Kanda, Kazuhito Tawaramoto, Mitsuru Hashiramoto, Fumiko Kawasaki, Michihiro Matsuki, Masashi Shimoda

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism

Pioglitazone preserves pancreatic β-cell morphology and function in diabetic animal models. In this study, we investigated the molecular mechanisms by which pioglitazone protects β-cells in diabetic db/db mice. In addition to the morphological anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15154d93b13e72bafa05c07a20166fa7
https://doi.org/10.1152/ajpendo.00388.2009

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Combination of DPP-4 inhibitor and PPARγ agonist exerts protective effects on pancreatic β-cells in diabetic db/db mice through the augmentation of IRS-2 expression

Autor: Mitsuru Hashiramoto, Tomohiko Kimura, Kenji Kohara, Seizo Okauchi, Kohei Kaku, Atsushi Obata, Hideaki Kaneto, Kazuhito Tawaramoto, Sumiko Hamamoto, Hidenori Hirukawa, Masashi Shimoda

Publikováno v: Molecular and cellular endocrinology. 413

We investigated the effects of long- and short-term treatment with pioglitazone (Pio) and/or alogliptin (Alo) on β-cells in diabetic db/db mice. Six-week-old male db/db mice received Pio (25 mg/kg, oral) and/or Alo (30 mg/kg, oral) for 4 weeks and f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f793e10d3cddbb5ea96e98257e12b74
https://pubmed.ncbi.nlm.nih.gov/26116826

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Protective effects of pioglitazone and/or liraglutide on pancreatic β-cells in db/db mice: Comparison of their effects between in an early and advanced stage of diabetes

Autor: Sumiko Hamamoto, Tomohiko Kimura, Hideaki Kaneto, Kazuhito Tawaramoto, Hidenori Hirukawa, Kohei Kaku, Mitsuru Hashiramoto, Masashi Shimoda, Seizo Okauchi, Kenji Kohara

Publikováno v: Molecular and cellular endocrinology. 400

The aim was to compare the protective effects of pioglitazone (PIO) and/or liraglutide (LIRA) on β-cells with the progression of diabetes. Male db/db mice were treated with PIO and/or LIRA for 2 weeks in an early and advanced stage. In an early stag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea37cf3023bc31c1c85ff42bc4c3a80
https://pubmed.ncbi.nlm.nih.gov/25463759

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Vildagliptin preserves the mass and function of pancreatic β cells via the developmental regulation and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes

Autor: Kenji Kohara, Sumiko Hamamoto, Yukiko Kanda, Fuminori Tatsumi, Mitsuru Hashiramoto, Masashi Shimoda, Kohei Kaku, Kazuhito Tawaramoto

Publikováno v: Diabetes, Obesity & Metabolism

Aim We investigated the molecular mechanisms by which vildagliptin preserved pancreatic β cell mass and function. Methods Morphological, biochemical and gene expression profiles of the pancreatic islets were investigated in male KK-Ay-TaJcl(KK-Ay) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cfad8d563a37eafa4ee42e91a493e31
https://pubmed.ncbi.nlm.nih.gov/22950702

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Self-inducible secretion of glucagon-like peptide-1 (GLP-1) that allows MIN6 cells to maintain insulin secretion and insure cell survival

Autor: Kazuhito Tawaramoto, Koji Nakashima, Hidenori Hirukawa, Kohei Kaku, Masashi Shimoda, Fuminori Tatsumi, Yukiko Kanda, Sumiko Hamamoto

Publikováno v: Molecular and cellular endocrinology. 349(2)

Based on the hypothesis that MIN6 cells could produce glucagon-like peptide-1 (GLP-1) to maintain cell survival, we analyzed the effects of GLP-1 receptor agonist, exendin-4 (Ex4), and antagonist, exendin-(9-39) (Ex9) on cell function and cell differ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926ad4212f17fed502a59a287b291360
https://pubmed.ncbi.nlm.nih.gov/22108438

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The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes

Autor: Yukiko Kanda, Sumiko Hamamoto, Kazuhito Tawaramoto, Kohei Kaku, Michihiro Matsuki, Mitsuru Hashiramoto, Masashi Shimoda

Publikováno v: Diabetologia

Aims/hypothesis We investigated the molecular mechanism by which the human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells in diabetic db/db mice. Methods Male db/db and m/m mice aged 10 weeks received liraglutide or vehi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84cb430151666e8b43462aac82efd0f8
https://pubmed.ncbi.nlm.nih.gov/21340625

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