Enantiomeric separation of tolperisone and eperisone by reversed-phase HPLC with cellulose tris(3-chloro-4-methylphenylcarbamate)-coated chiral column

Autor: Sumiko Iwasa, Yuri Owada, Kiyomi Sadamoto, Takeshi Fukushima, Hideaki Ichiba, Mizuho Takahashi

Publikováno v: Biomedical Chromatography. 28:102-105

Enantiomeric separations of centrally acting muscle relaxants, that is, tolperisone (TOL) and eperisone (EP), that are marketed as racemates were investigated by reversed-phase high-performance liquid chromatography (HPLC) on a polysaccharide-based c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64bee3ff6cfcb32b6f865d691f6a3ab9
https://doi.org/10.1002/bmc.2892

Chromatographic Analysis of Conformationally Changed Insulin and Its Cytotoxic Effect on PC12 Cells

Autor: Takeshi Fukushima, Minako Nakai, Akina Enomoto, Satomi Onoue, Takehiko Yajima, Sumiko Iwasa

Publikováno v: Journal of Health Science. 55:825-831

With the aim of developing a quality control system for insulin formulations in the pharmaceutical industry, we tested the feasibility of chromatographic methods, including reversed-phase high-performance liquid chromatography (RP-HPLC) and capillary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2087449ef19e20dc846eac69a1051d24
https://doi.org/10.1248/jhs.55.825

Structural transition of glucagon in the concentrated solution observed by electrophoretic and spectroscopic techniques

Autor: Keitatsu Koh, Fumie Katoh, Sumiko Iwasa, Takashi Kojima, Takehiko Yajima, Kazuhiro Debari, Satomi Onoue, Yoshihisa Matsuda

Publikováno v: Journal of Chromatography A. 1109:167-173

Glucagon, a polypeptide hormone consisting of 29 amino acid residues, tends to form gel-like fibrillar aggregates, and the glucagon fibril, as well as other pathologically related fibrils including prion, amylin, and beta-amyloid, have been found to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa341c4f7281ac6a5be0b2610166327
https://doi.org/10.1016/j.chroma.2005.11.130

Enantiomeric Separation of Monosubstituted Tryptophan Derivatives and Metabolites by HPLC with a Cinchona Alkaloid-Based Zwitterionic Chiral Stationary Phase and Its Application to the Evaluation of the Optical Purity of Synthesized 6-Chloro-l-Tryptophan

Autor: Hideaki Iizuka, Ippei Furuta, Hidemasa Hikawa, Yuusaku Yokoyama, Mayu Onozato, Takeshi Fukushima, Hideaki Ichiba, Sumiko Iwasa, Anna Sugiura

Publikováno v: International Journal of Tryptophan Research : IJTR
International Journal of Tryptophan Research, Vol 8 (2015)
International Journal of Tryptophan Research, Vol 2015, Iss 8, Pp 1-5 (2015)

6-Chlorotryptophan possesses unique bioactivity and can be used as a precursor for several bioactive compounds in medicinal chemistry. It was enantioselectively synthesized by condensing 6-chloroindole with racemic N-acetylserine, followed by enzymat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051198327da0ce44edfc57a1bb3de30b
https://pubmed.ncbi.nlm.nih.gov/25624766

Enantiomeric separation of tolperisone and eperisone by reversed-phase HPLC with cellulose tris(3-chloro-4-methylphenylcarbamate)-coated chiral column

Autor: Yuri, Owada, Mizuho, Takahashi, Sumiko, Iwasa, Hideaki, Ichiba, Kiyomi, Sadamoto, Takeshi, Fukushima

Publikováno v: Biomedical chromatography : BMC. 28(1)

Enantiomeric separations of centrally acting muscle relaxants, that is, tolperisone (TOL) and eperisone (EP), that are marketed as racemates were investigated by reversed-phase high-performance liquid chromatography (HPLC) on a polysaccharide-based c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4bc10e01ed7998489f55a2d753b3a2c8
https://pubmed.ncbi.nlm.nih.gov/23505060