Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Sumihiro Maeda"'
Publikováno v:
Regenerative Therapy, Vol 25, Iss , Pp 250-263 (2024)
Introduction: 17β-Estradiol (E2) is a sex hormone that has been previously demonstrated to have neurotherapeutic effects on animal models of Alzheimer's disease (AD). However, clinical trials on E2 replacement therapy for preventing AD onset yielded
Externí odkaz:
https://doaj.org/article/4870c306d3b9496b9b0064184d2d36a0
Autor:
Sopak Supakul, Rei Murakami, Chisato Oyama, Tomoko Shindo, Yuki Hatakeyama, Maika Itsuno, Hiroko Bannai, Shinsuke Shibata, Sumihiro Maeda, Hideyuki Okano
Publikováno v:
Inflammation and Regeneration, Vol 44, Iss 1, Pp 1-21 (2024)
Abstract Background The development of induced pluripotent stem cells (iPSCs) technology has enabled human cellular disease modeling for inaccessible cell types, such as neural cells in the brain. However, many of the iPSC-derived disease models esta
Externí odkaz:
https://doaj.org/article/40cba472ec6b49c09723aa64390eeb24
Autor:
Sopak Supakul, Yuki Hatakeyama, Nicolas Leventoux, Maika Itsuno, Naoko Numata, Hayato Hiramine, Satoru Morimoto, Atsushi Iwata, Sumihiro Maeda, Hideyuki Okano
Publikováno v:
Aging Brain, Vol 4, Iss , Pp 100101- (2023)
Human neural cell models derived from induced pluripotent stem cells (iPSCs) have been widely accepted to model various neurodegenerative diseases such as Alzheimer’s disease (AD) in vitro. Although the most common sources of iPSCs are fibroblasts
Externí odkaz:
https://doaj.org/article/5cff9b1ff6d34f399063dad06d1650ce
Autor:
Sopak Supakul, Nicolas Leventoux, Hajime Tabuchi, Masaru Mimura, Daisuke Ito, Sumihiro Maeda, Hideyuki Okano
Publikováno v:
Stem Cell Research, Vol 62, Iss , Pp 102802- (2022)
Sporadic Alzheimer’s disease (sAD) is a neurodegenerative disease that has the highest prevalence among patients with dementia. The genetic risk factors for sAD are comprised of many single nucleotide polymorphisms (SNPs), as indicated by genome-wi
Externí odkaz:
https://doaj.org/article/92fbc64158904786b429bdba4f950bd1
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Alzheimer’s disease (AD) is an aging-dependent neurodegenerative disease that impairs cognitive function. Although the main pathologies of AD are the aggregation of amyloid-beta (Aβ) and phosphorylated Tau protein, the mechanisms that lead to thes
Externí odkaz:
https://doaj.org/article/9e83c20e667e44e1a12dd499e9e741f4
Autor:
Melanie Das, Sumihiro Maeda, Bozhong Hu, Gui-Qiu Yu, Weikun Guo, Isabel Lopez, Xinxing Yu, Chao Tai, Xin Wang, Lennart Mucke
Publikováno v:
Neurobiology of Disease, Vol 117, Iss , Pp 181-188 (2018)
Neural network dysfunction may contribute to functional decline and disease progression in neurodegenerative disorders. Diverse lines of evidence suggest that neuronal accumulation of tau promotes network dysfunction and cognitive decline. The A152T-
Externí odkaz:
https://doaj.org/article/2e833ca75e0e4c69909fd62cdfa1e395
Autor:
Julie A Harris, Akihiko Koyama, Sumihiro Maeda, Kaitlyn Ho, Nino Devidze, Dena B Dubal, Gui-Qiu Yu, Eliezer Masliah, Lennart Mucke
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45881 (2012)
Accumulation of hyperphosphorylated tau in the entorhinal cortex (EC) is one of the earliest pathological hallmarks in patients with Alzheimer's disease (AD). It can occur before significant Aβ deposition and appears to "spread" into anatomically co
Externí odkaz:
https://doaj.org/article/f8e15b3e38db4db0b14cf7b0ad584b67
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience
Alzheimer’s disease (AD) is an aging-dependent neurodegenerative disease that impairs cognitive function. Although the main pathologies of AD are the aggregation of amyloid-beta (Aβ) and phosphorylated Tau protein, the mechanisms that lead to thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614a7f1a5afd61e9ea385b3436af6c29
https://doi.org/10.3389/fnagi.2021.768948
https://doi.org/10.3389/fnagi.2021.768948
Autor:
Sumihiro Maeda, Shin-ichi Hisanaga, Hirotaka Watanabe, Akihiko Takashima, Takeshi Ikeuchi, Naruhiko Sahara, Celeste M. Karch, Mutsuki Amano, Hideyuki Okano, Taeko Kimura, Sho Yoshimatsu, Mari Nakamura, Fumihiko Kisa, Kozo Kaibuchi, Tomohiro Miyasaka, Seiji Shiozawa, Daisuke Tsuboi
Publikováno v:
Stem Cell Reports
Summary Mutations in the microtubule-associated protein tau (MAPT) gene are known to cause familial frontotemporal dementia (FTD). The R406W tau mutation is a unique missense mutation whose patients have been reported to exhibit Alzheimer’s disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d9a568659ad2b1e40b5fc555861ee4
http://europepmc.org/articles/PMC6829766
http://europepmc.org/articles/PMC6829766
Autor:
Kohki Ishida, Shuichi Kojima, Sumihiro Maeda, Akihiko Takashima, Marino Saito, Akira Nakamura, Yoshiyuki Soeda
Publikováno v:
Journal of Alzheimer's Disease. 68:1677-1686
Alzheimer's disease pathology is characterized by extracellular deposits of amyloid-β (Aβ) and intracellular inclusions of hyperphosphorylated tau. Although genetic studies of familial Alzheimer's disease suggest a causal link between Aβ and disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca136c29576921026b6b5804369e9fc4
https://doi.org/10.3233/jad-181001
https://doi.org/10.3233/jad-181001