Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sumiaki Fukuda"'
Autor:
Sumiaki Fukuda, Akihiro Kaneshige, Takayuki Kaji, Yu-taro Noguchi, Yusei Takemoto, Lidan Zhang, Kazutake Tsujikawa, Hiroki Kokubo, Akiyoshi Uezumi, Kazumitsu Maehara, Akihito Harada, Yasuyuki Ohkawa, So-ichiro Fukada
Publikováno v:
eLife, Vol 8 (2019)
In overloaded and regenerating muscle, the generation of new myonuclei depends on muscle satellite cells (MuSCs). Because MuSC behaviors in these two environments have not been considered separately, MuSC behaviors in overloaded muscle remain unexami
Externí odkaz:
https://doaj.org/article/c9dd6cfe56304bc1beb9e2e5e662aab9
Autor:
Hiroshi Sakai, Sumiaki Fukuda, Miki Nakamura, Akiyoshi Uezumi, Yu-Taro Noguchi, Takahiko Sato, Mitsuhiro Morita, Harumoto Yamada, Kunihiro Tsuchida, Shahragim Tajbakhsh, So-Ichiro Fukada
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177516 (2017)
Myogenic stem cells are a promising avenue for the treatment of muscular disorders. Freshly isolated muscle stem cells have a remarkable engraftment ability in vivo, but their cell number is limited. Current conventional culture conditions do not all
Externí odkaz:
https://doaj.org/article/c233ac686f4343138a5066c3fc059742
Autor:
Masahiko Yamaguchi, Satoshi Murakami, Tomohiro Yoneda, Miki Nakamura, Lidan Zhang, Akiyoshi Uezumi, Sumiaki Fukuda, Hiroki Kokubo, Kazutake Tsujikawa, So-Ichiro Fukada
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138517 (2015)
Nrf2 is a master regulator of oxidative stresses through the induction of anti-oxidative genes. Nrf2 plays roles in maintaining murine hematopoietic stem cells and fly intestinal stem cells. The canonical Notch signaling pathway is also crucial for m
Externí odkaz:
https://doaj.org/article/c30164e8a6324939be8b5b931696bf84
Publikováno v:
Journal of Diabetes Research, Vol 2014 (2014)
Externí odkaz:
https://doaj.org/article/51827d151bb045cf914c2997bb9efeed
Autor:
Takahisa Yamada, Kazuhito Harada, Takashi Kawai, Tomohiko Sasase, Yu Motohashi, Sumiaki Fukuda, Nobuya Ogawa, Masao Yamanaka, Naoto Ogawa, Hironobu Tadaki, Yasufumi Toriniwa, Takeshi Ohta
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 48(3):381-388
G protein-coupled receptor 119 (GPR119) expression in pancreatic β-cells and intestinal L-cells is a potential therapeutic target for the treatment of type 2 diabetes. Previously, we have reported that the GPR119 agonist JTP-109192 improves glucose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f43a94a8725c54012ebbe8cc863305
http://hdl.handle.net/2433/261718
http://hdl.handle.net/2433/261718
Autor:
Takahisa Yamada, Takeshi Ohta, Kazuhito Harada, Hironobu Tadaki, Yasufumi Toriniwa, Sumiaki Fukuda, Tomohiko Sasase
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 46:910-919
G-protein coupled receptor 119 (GPR119) expression in pancreatic β-cells and intestinal L cells is a potential therapeutic target for treating type 2 diabetes. A natural GPR119 agonist oleoylethanolamide is well known to enhance a glucose-stimulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d60e0b5e705e5da0f0e195943d2213e
https://doi.org/10.1111/1440-1681.13152
https://doi.org/10.1111/1440-1681.13152
Autor:
Sumiaki Fukuda, Takashi Watanabe, Jun Mizukami, Minoru Ubukata, Suwa Katsunori, Kazuhito Harada, Takashi Inaba, Motohide Sato, Tamotsu Negoro, Genki Mori
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2100-2106
We describe here a novel GPR119 agonist 24, which showed a potent and long-acting hypoglycemic effect in rats via oral dosing. For the discovery of 24, we chose compound 5, which possessed an oxadiazole linker, as a lead compound among our spirocycli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd19e583f5fc31b1c209ac9681bd986
https://doi.org/10.1016/j.bmcl.2019.07.004
https://doi.org/10.1016/j.bmcl.2019.07.004
Autor:
M Sugimoto, Yukihito Ishii, F Kuroki, Yusuke Kemmochi, Dai Nakae, Masao Yamanaka, Katsuhiro Miyajima, Tomohiko Sasase, Ryuhei Sano, Sumiaki Fukuda, Yuzo Yasui, Takeshi Ohta
Publikováno v:
Physiol Res
Glomerular hyperfiltration is observed in an early stage of kidney diseases including diabetic nephropathy. A better understanding of pathophysiological changes in glomerular hyperfiltration is essential for development of new therapies to prevent ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0541e2e37425983f60868fdce5106323
https://pubmed.ncbi.nlm.nih.gov/33453716
https://pubmed.ncbi.nlm.nih.gov/33453716
Autor:
Isamu Matsuda, Suwa Katsunori, Kenta Aoki, Kazuhito Harada, Jun Mizukami, Sumiaki Fukuda, Sho Kadowaki, Takashi Inaba, Takashi Watanabe, Yoshitoshi Kodama, Shinji Yata, Yasuhiro Oe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:1228-1233
Exploration of alternative structures of the substituted piperidine or piperazine ring which are characteristic in most of the reported GPR119 agonists provided novel spirocyclic cyclohexane derivatives. The representative 17 with a high three-dimens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf9b6294d0af2043cb0f11fc589e6c54
https://doi.org/10.1016/j.bmcl.2018.02.044
https://doi.org/10.1016/j.bmcl.2018.02.044
Autor:
Akihiro Kaneshige, Akihito Harada, Hiroki Kokubo, Takayuki Kaji, Yusei Takemoto, Akiyoshi Uezumi, Yasuyuki Ohkawa, Kazutake Tsujikawa, So-ichiro Fukada, Lidan Zhang, Yu-taro Noguchi, Sumiaki Fukuda, Kazumitsu Maehara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::681b0a71943033d2fd73ed1c19d689fd
https://doi.org/10.7554/elife.48284.031
https://doi.org/10.7554/elife.48284.031
