Výsledky vyhledávání - "Sumeet Poudel"

Interaction between DUE-B and Treslin is required to load Cdc45 on chromatin in human cells

Autor: Michael G. Kemp, Jianhong Yao, Sumeet Poudel, Michael Leffak

A key step in the initiation of eukaryotic DNA replication is the binding of the activator protein Cdc45 to promote MCM helicase unwinding of the origin template. We show here that the c-myc origin DNA unwinding element-binding protein, DUE-B, intera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe2b43e851b9ea1ff33392bfcadd97f
https://europepmc.org/articles/PMC6139568/

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Protein Phosphatase 2A and Cdc7 Kinase Regulate the DNA Unwinding Element-binding Protein in Replication Initiation

Autor: Michael Leffak, Jianhong Yao, Yanzhe Gao, Eric J. Romer, Lubna Abu-Niaaj, Sumeet Poudel

Publikováno v: Journal of Biological Chemistry. 289:35987-36000

The DNA unwinding element (DUE)-binding protein (DUE-B) binds to replication origins coordinately with the minichromosome maintenance (MCM) helicase and the helicase activator Cdc45 in vivo, and loads Cdc45 onto chromatin in Xenopus egg extracts. Hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68cf72329cd6be51508a4a72fe030cff
https://doi.org/10.1074/jbc.m114.589119

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