Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Sumeet P. Singh"'
Autor:
Eduardo H. Gilglioni, Ao Li, Wadsen St-Pierre-Wijckmans, Tzu-Keng Shen, Israel Pérez-Chávez, Garnik Hovhannisyan, Michela Lisjak, Javier Negueruela, Valerie Vandenbempt, Julia Bauzá-Martinez, Jose M. Herranz, Daria Ezeriņa, Stéphane Demine, Zheng Feng, Thibaut Vignane, Lukas Otero Sanchez, Flavia Lambertucci, Alena Prašnická, Jacques Devière, David C. Hay, Jose A. Encinar, Sumeet Pal Singh, Joris Messens, Milos R. Filipovic, Hayley J. Sharpe, Eric Trépo, Wei Wu, Esteban N. Gurzov
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Fat accumulation, de novo lipogenesis, and glycolysis are key drivers of hepatocyte reprogramming and the consequent metabolic dysfunction-associated steatotic liver disease (MASLD). Here we report that obesity leads to dysregulated expressi
Externí odkaz:
https://doaj.org/article/47d15d12bd9c4154ade149ceeddbddb9
Autor:
Ariel A. Valiente-Gabioud, Inés Garteizgogeascoa Suñer, Agata Idziak, Arne Fabritius, Jérome Basquin, Julie Angibaud, U. Valentin Nägerl, Sumeet Pal Singh, Oliver Griesbeck
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Calcium in interstitial fluids is central to systemic physiology and a crucial ion pool for entry into cells through numerous plasma membrane channels. Its study has been limited by the scarcity of methods that allow monitoring in tight inte
Externí odkaz:
https://doaj.org/article/2e45164c35d54f6283163a236c70892f
Autor:
Liliia Ibneeva, Sumeet Pal Singh, Anupam Sinha, Sema Elif Eski, Rebekka Wehner, Luise Rupp, Iryna Kovtun, Juan Alberto Pérez-Valencia, Alexander Gerbaulet, Susanne Reinhardt, Manja Wobus, Malte von Bonin, Jaime Sancho, Frances Lund, Andreas Dahl, Marc Schmitz, Martin Bornhäuser, Triantafyllos Chavakis, Ben Wielockx, Tatyana Grinenko
Publikováno v:
PLoS Biology, Vol 22, Iss 2, p e3002517 (2024)
A subpopulation of deeply quiescent, so-called dormant hematopoietic stem cells (dHSCs) resides at the top of the hematopoietic hierarchy and serves as a reserve pool for HSCs. The state of dormancy protects the HSC pool from exhaustion throughout li
Externí odkaz:
https://doaj.org/article/6e6a2cac4f004ac1b93ef75582908b4f
Autor:
Valerie Vandenbempt, Sema Elif Eski, Manoja K. Brahma, Ao Li, Javier Negueruela, Ylke Bruggeman, Stéphane Demine, Peng Xiao, Alessandra K. Cardozo, Nicolas Baeyens, Luciano G. Martelotto, Sumeet Pal Singh, Eliana Mariño, Conny Gysemans, Esteban N. Gurzov
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108694- (2024)
Summary: An altered gut microbiota is associated with type 1 diabetes (T1D), affecting the production of short-chain fatty acids (SCFA) and glucose homeostasis. We previously demonstrated that enhancing serum acetate and butyrate using a dietary supp
Externí odkaz:
https://doaj.org/article/5023158edf454661a1c63b4ee36c62b7
Autor:
Aiswarya Jaiswal, Pushkar Singh Rawat, Sumeet Kumar Singh, Jasvinder Singh Bhatti, Amit Khurana, Umashanker Navik
Publikováno v:
Advances in Redox Research, Vol 9, Iss , Pp 100084- (2023)
The anthracycline anticancer drug doxorubicin (Dox) is widely prescribed for treating lung, ovary, breast, lymphoma, sarcoma, and pediatric cancer. Mechanistically, Dox intercalates the DNA and inhibits the topoisomerase II enzyme in fast-proliferati
Externí odkaz:
https://doaj.org/article/9fe916f805c1404f84d0c30653ae7c87
Autor:
Mírian Romitti, Adrien Tourneur, Barbara de Faria da Fonseca, Gilles Doumont, Pierre Gillotay, Xiao-Hui Liao, Sema Elif Eski, Gaetan Van Simaeys, Laura Chomette, Helene Lasolle, Olivier Monestier, Dominika Figini Kasprzyk, Vincent Detours, Sumeet Pal Singh, Serge Goldman, Samuel Refetoff, Sabine Costagliola
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Hypothyroidism is a common condition that cannot always be satisfactorily treated through continued hormone replacement. Here the authors report the generation of transplantable thyroid organoids derived from human embryonic stem cells that can resto
Externí odkaz:
https://doaj.org/article/09cc7e0c596249d48554d6f0bf23cd9f
Autor:
Peng Xiao, Tatiana Takiishi, Natalia Moretti Violato, Giada Licata, Francesco Dotta, Guido Sebastiani, Lorella Marselli, Sumeet Pal Singh, Mozes Sze, Geert Van Loo, Emmanuel Dejardin, Esteban Nicolas Gurzov, Alessandra Kupper Cardozo
Publikováno v:
Cell Death and Disease, Vol 13, Iss 5, Pp 1-11 (2022)
Abstract The transcription factor nuclear factor-κB (NF-κB) has a key role in the pathogenesis of diabetes and its complications. Although activation of the canonical NF-κB pathway in β-cells is generally deleterious, little is known about the ro
Externí odkaz:
https://doaj.org/article/1277c1357f0c4eb8aed8ef4ecac0ad73
Autor:
Indrajit Sahu, Sachitanand M. Mali, Prasad Sulkshane, Cong Xu, Andrey Rozenberg, Roni Morag, Manisha Priyadarsini Sahoo, Sumeet K. Singh, Zhanyu Ding, Yifan Wang, Sharleen Day, Yao Cong, Oded Kleifeld, Ashraf Brik, Michael H. Glickman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
The 20S particle is part of the 26S proteasome, but also exists as a free complex. Here, the authors outline signature activities of the 20S and combine chemical, structural, functional and proteomic assays to show that the 20S can degrade ubiquitin
Externí odkaz:
https://doaj.org/article/46cc92bf4c3f4fcfb5bb5b4fa465398a
Autor:
SARITA KUMARI, BALWANT SINGH, SUMEET KUMAR SINGH, DHRITI SATYA, SANGEETA SINGH, KABITA TRIPATHY, KISHOR GAIKWAD, VANDNA RAI, NAGENDRA KUMAR SINGH
Publikováno v:
The Indian Journal of Agricultural Sciences, Vol 91, Iss 3 (2022)
Wild progenitor species of rice (Oryza rufipogon Griff./ Oryza nivara Sharma et. Shastry) are rich source of genes for both the biotic as well as abiotic stress tolerance. Wild rice accession NKSWR 173 has been identified as highly tolerant to salini
Externí odkaz:
https://doaj.org/article/1a5b43cfc91c46569b32b4b0428a3d99
Autor:
SARITA KUMARI, SUMEET KUMAR SINGH, VINAY KUMAR SHARMA, RAJESH KUMAR, MANAS MATHUR, TARUN KUMAR UPADHYAY, RAKESH KUMAR PRAJAPAT
Publikováno v:
The Indian Journal of Agricultural Sciences, Vol 91, Iss 9 (2021)
The discovery of the CRISPR/Cas microbial adaptive immune system and its ongoing development as a genome editing tool represents the work of many scientists around the world. The time line of CRISPR/Cas system shows that this technology is improving
Externí odkaz:
https://doaj.org/article/fb7919464a3d43c79e35cb3e34db7fd9