Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Sumeet Mahajan"'
Autor:
Yong En Kok, Anna Crisford, Andrew Parkes, Seshasailam Venkateswaran, Richard Oreffo, Sumeet Mahajan, Michael Pound
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Raman spectroscopy is a rapid method for analysing the molecular composition of biological material. However, noise contamination in the spectral data necessitates careful pre-processing prior to analysis. Here we propose an end-to-end Convo
Externí odkaz:
https://doaj.org/article/db6e9c082aab4f35a58665aaf476912c
Autor:
Rachel L. Kidd, Akosua Agyemang-Prempeh, Alan Sanderson, Charlotte Stuart, Sumeet Mahajan, Carl A. Verschuur, Tracey A. Newman
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Low-grade chronic inflammation is associated with many age-related conditions. Non-invasive methods to monitor low-grade chronic inflammation may improve the management of older people at risk of poorer outcomes. This longitudinal cohort stu
Externí odkaz:
https://doaj.org/article/a1f1b475dd39425fbe7e4fa29e4559e1
Autor:
Christopher D. Standish, Jacob Trend, Jacob Kleboe, Thomas B. Chalk, Sumeet Mahajan, J. Andy Milton, Tessa M. Page, Laura F. Robinson, Joseph A. Stewart, Gavin L. Foster
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The chemical and isotopic composition of stony coral skeletons form an important archive of past climate. However, these reconstructions are largely based on empirical relationships often complicated by “vital effects” arising from uncer
Externí odkaz:
https://doaj.org/article/0f674e5a4ad0438ebc23b78a1755daf0
Autor:
Ysanne Pritchard, Aikta Sharma, Claire Clarkin, Helen Ogden, Sumeet Mahajan, Rubén J. Sánchez-García
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract We present a topological method for the detection and quantification of bone microstructure from non-linear microscopy images. Specifically, we analyse second harmonic generation (SHG) and two photon excited autofluorescence (TPaF) images of
Externí odkaz:
https://doaj.org/article/99ce84f3a0c142309f00bde2bf715e8a
Autor:
Marzanna Szwaj, Ian A. Davidson, Peter B. Johnson, Greg Jasion, Yongmin Jung, Seyed Reza Sandoghchi, Krzysztof P. Herdzik, Konstantinos N. Bourdakos, Natalie V. Wheeler, Hans Christian Mulvad, David J. Richardson, Francesco Poletti, Sumeet Mahajan
Publikováno v:
Sensors, Vol 24, Iss 8, p 2482 (2024)
Label-free and multiphoton micro-endoscopy can transform clinical histopathology by providing an in situ tool for diagnostic imaging and surgical treatment in diseases such as cancer. Key to a multiphoton imaging-based micro-endoscopic device is the
Externí odkaz:
https://doaj.org/article/43f7ca96aea24a0f8432c00375766a3f
Autor:
Aikta Sharma, Alice Goring, Peter B. Johnson, Roger J. H. Emery, Eric Hesse, Alan Boyde, Bjorn R. Olsen, Andrew A. Pitsillides, Richard O. C. Oreffo, Sumeet Mahajan, Claire E. Clarkin
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 3 (2021)
Collagen assembly during development is essential for successful matrix mineralisation, which determines bone quality and mechanocompetence. However, the biochemical and structural perturbations that drive pathological skeletal collagen configuration
Externí odkaz:
https://doaj.org/article/7641ca0ae1294d25a608e315cdaa11d3
Autor:
Aikta Sharma, Alice Goring, Katherine A. Staines, Roger J.H. Emery, Andrew A. Pitsillides, Richard O.C. Oreffo, Sumeet Mahajan, Claire E. Clarkin
Publikováno v:
Matrix Biology Plus, Vol 5, Iss , Pp - (2020)
Mineralization of bone is achieved by the sequential maturation of the immature amorphous calcium phase to mature hydroxyapatite (HA) and is central in the process of bone development and repair. To study normal and dysregulated mineralization in vit
Externí odkaz:
https://doaj.org/article/f9d392ccb5454c69a6449a77a2dcdb5e
Autor:
Mark G Jones, Orestis G Andriotis, James JW Roberts, Kerry Lunn, Victoria J Tear, Lucy Cao, Kjetil Ask, David E Smart, Alessandra Bonfanti, Peter Johnson, Aiman Alzetani, Franco Conforti, Regan Doherty, Chester Y Lai, Benjamin Johnson, Konstantinos N Bourdakos, Sophie V Fletcher, Ben G Marshall, Sanjay Jogai, Christopher J Brereton, Serena J Chee, Christian H Ottensmeier, Patricia Sime, Jack Gauldie, Martin Kolb, Sumeet Mahajan, Aurelie Fabre, Atul Bhaskar, Wolfgang Jarolimek, Luca Richeldi, Katherine MA O'Reilly, Phillip D Monk, Philipp J Thurner, Donna E Davies
Publikováno v:
eLife, Vol 7 (2018)
Matrix stiffening with downstream activation of mechanosensitive pathways is strongly implicated in progressive fibrosis; however, pathologic changes in extracellular matrix (ECM) that initiate mechano-homeostasis dysregulation are not defined in hum
Externí odkaz:
https://doaj.org/article/2541e80c33c2458ba21e589aed967251
Autor:
Timothy A Kelf, Wataru Hoshii, Paul H Otsuka, Hirotaka Sakuma, Istvan A Veres, Robin M Cole, Sumeet Mahajan, Jeremy J Baumberg, Motonobu Tomoda, Osamu Matsuda, Oliver B Wright
Publikováno v:
New Journal of Physics, Vol 15, Iss 2, p 023013 (2013)
We image the gigahertz vibrational modes of a plasmonic–phononic crystal at sub-micron resolution by means of an ultrafast optical technique, using a triangular array of spherical gold nanovoids as a sample. Light is strongly coupled to the plasmon
Externí odkaz:
https://doaj.org/article/33e17c1c5f854a7d9699ea775bc6d895
Publikováno v:
The Journal of Neuroscience. 43:2988-3006
Tauopathies including Alzheimer's disease, are characterized by progressive cognitive decline, neurodegeneration, and intraneuronal aggregates comprised largely of the axonal protein Tau. It has been unclear whether cognitive deficits are a consequen