Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Sumedha Agashe"'
Autor:
Sumedha Agashe, Chinnu Rose Joseph, Teresa Anne Clarisse Reyes, Demis Menolfi, Michele Giannattasio, Anja Waizenegger, Barnabas Szakal, Dana Branzei
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Smc5/6, part of the structural maintenance of chromosomes (SMC) family, plays roles in genome structural integrity. Here the authors reveal that Smc5/6 acts jointly with Top3 within the STR complex to mediate DNA replication completion at genomic nat
Externí odkaz:
https://doaj.org/article/05276fd617f0402ba03a03fa5c996f82
Autor:
Alice Meroni, Jan Grosser, Sumedha Agashe, Natasha Ramakrishnan, Jessica Jackson, Priyanka Verma, Laura Baranello, Alessandro Vindigni
Publikováno v:
Science Advances. 8
DNA topoisomerase 1 (TOP11) inhibitors are mainstays of anticancer therapy. These drugs trap TOP1 on DNA, stabilizing the TOP1-cleavage complex (TOP1-cc). The accumulation of TOP1-ccs perturbs DNA replication fork progression, leading to DNA breaks a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a324f0bb62f1bb303b797682634faf40
https://doi.org/10.1126/sciadv.abq0648
https://doi.org/10.1126/sciadv.abq0648
Autor:
Jeremy T Baeten, Sumedha Agashe, Annabel Quinet, Kimberly B. Johansson, Alessandro Vindigni, Geoffrey L. Uy, Daniel C. Link
Publikováno v:
Blood. 140:8787-8788
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b97e504e192369ac6c29c578a8b11b33
https://doi.org/10.1182/blood-2022-170238
https://doi.org/10.1182/blood-2022-170238
Autor:
Anja Waizenegger, Demis Menolfi, Sumedha Agashe, Teresa Anne Clarisse Reyes, Dana Branzei, Barnabas Szakal, Michele Giannattasio, Chinnu Rose Joseph
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Smc5/6 is essential for genome structural integrity by yet unknown mechanisms. Here we find that Smc5/6 co-localizes with the DNA crossed-strand processing complex Sgs1-Top3-Rmi1 (STR) at genomic regions known as natural pausing sites (NPSs) where it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d811f707ae4a54ff46c34db637b7ef3d
https://doi.org/10.1038/s41467-021-22217-w
https://doi.org/10.1038/s41467-021-22217-w
