Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sumeda, Nandadasa"'
Autor:
Sumeda Nandadasa, Caroline M. Kraft, Lauren W. Wang, Anna O’Donnell, Rushabh Patel, Heon Yung Gee, Kay Grobe, Timothy C. Cox, Friedhelm Hildebrandt, Suneel S. Apte
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Ciliogenesis is a complex process requiring hundreds of molecules, although few secreted proteins have been implicated. Here, the authors show that the secreted metalloproteases ADAMTS9 and ADAMTS20 intracellularly regulate ciliogenesis from unique p
Externí odkaz:
https://doaj.org/article/ab5baac1ec5848ec9b9f690a16ccfcb8
Autor:
Sumeda Nandadasa, Cyril Burin des Roziers, Christopher Koch, Karin Tran-Lundmark, María T. Dours-Zimmermann, Dieter R. Zimmermann, Sophie Valleix, Suneel S. Apte
Publikováno v:
Matrix Biology Plus, Vol 10, Iss , Pp 100064- (2021)
Two inherent challenges in the mechanistic interpretation of protease-deficient phenotypes are defining the specific substrate cleavages whose reduction generates the phenotypes and determining whether the phenotypes result from loss of substrate fun
Externí odkaz:
https://doaj.org/article/05b26508a52446369487b95a2ee971df
Autor:
Sumeda Nandadasa, Jason M Szafron, Vai Pathak, Sae-Il Murtada, Caroline M Kraft, Anna O'Donnell, Christian Norvik, Clare Hughes, Bruce Caterson, Miriam S Domowicz, Nancy B Schwartz, Karin Tran-Lundmark, Martina Veigl, David Sedwick, Elliot H Philipson, Jay D Humphrey, Suneel S Apte
Publikováno v:
eLife, Vol 9 (2020)
The umbilical artery lumen closes rapidly at birth, preventing neonatal blood loss, whereas the umbilical vein remains patent longer. Here, analysis of umbilical cords from humans and other mammals identified differential arterial-venous proteoglycan
Externí odkaz:
https://doaj.org/article/9109ace5da5c44e6ba1fbd9d2ece7d9d
Publikováno v:
Cell Reports, Vol 11, Iss 10, Pp 1519-1528 (2015)
Despite the significance for fetal nourishment in mammals, mechanisms of umbilical cord vascular growth remain poorly understood. Here, the secreted metalloprotease ADAMTS9 is shown to be necessary for murine umbilical cord vascular development. Rest
Externí odkaz:
https://doaj.org/article/b1caceeda01d45b0ae38501470c933af
Autor:
Sumeda Nandadasa, Daniel Martin, Gauravi Deshpande, Karyn L. Robert, M. Sharon Stack, Yoshifumi Itoh, Suneel S. Apte
SummaryThe secreted metalloproteases ADAMTS9 and ADAMTS20 are implicated in extracellular matrix (ECM) proteolysis and primary cilium biogenesis. Here, we show that clonal gene-edited RPE-1 cells in whichADAMTS9was inactivated, and which constitutive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3aac8acfc281635a147f5bb7a1b455
https://doi.org/10.1101/2022.10.17.512574
https://doi.org/10.1101/2022.10.17.512574
Autor:
Ayako Murao, Sumeda Nandadasa, Lorin E. Olson, Anna O’Donnell, Ronald J. Midura, Suneel S. Apte, Yu Yamaguchi
Publikováno v:
Matrix Biology. 97:40-57
Little is known about extracellular matrix (ECM) contributions to formation of the earliest cell lineages in the embryo. Here, we show that the proteoglycan versican and glycosaminoglycan hyaluronan are associated with emerging Flk1+hematoendothelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09045829e8b8af6d78e586475efaf975
https://doi.org/10.1016/j.matbio.2021.01.002
https://doi.org/10.1016/j.matbio.2021.01.002
Autor:
Sumeda, Nandadasa, Anna, O'Donnell, Ayako, Murao, Yu, Yamaguchi, Ronald J, Midura, Lorin, Olson, Suneel S, Apte
Publikováno v:
Matrix Biol
Little is known about extracellular matrix (ECM) contributions to formation of the earliest cell lineages in the embryo. Here, we show that the proteoglycan versican and glycosaminoglycan hyaluronan are associated with emerging Flk1(+) hematoendothel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05e2286e1044ce7b862c2ed962cc5f62
https://pubmed.ncbi.nlm.nih.gov/33454424
https://pubmed.ncbi.nlm.nih.gov/33454424
Autor:
Bruce Caterson, Jay D. Humphrey, Vai Pathak, Nancy B. Schwartz, Anna O’Donnell, Clare Elizabeth Hughes, Elliot H. Philipson, David Sedwick, Jason M. Szafron, Martina L. Veigl, Karin Tran-Lundmark, Sumeda Nandadasa, Miriam S. Domowicz, Caroline M. Kraft, Sae-Il Murtada, Christian Norvik, Suneel S. Apte
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
The umbilical artery lumen occludes rapidly at birth, preventing blood loss, whereas the umbilical vein remains patent, providing the newborn with a placental infusion. Here, we identify differential arterial-venous proteoglycan dynamics as a determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41cfbb9061a864de0511e049fba9ed8e
https://doi.org/10.7554/elife.60683
https://doi.org/10.7554/elife.60683
Autor:
Vai Pathak, Miriam S. Domowicz, Elliot H. Philipson, Karin Tran-Lundmark, Caroline M. Kraft, Jason M. Szafron, Jay D. Humphrey, Christian Norvik, Sumeda Nandadasa, Bruce Caterson, Martina L. Veigl, Anna O’Donnell, Suneel S. Apte, Sae-Il Murtada, Clare Elizabeth Hughes, David Sedwick, Nancy B. Schwartz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f766a471df582eb506ffde1a616f093f
https://doi.org/10.7554/elife.60683.sa2
https://doi.org/10.7554/elife.60683.sa2
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38756 (2012)
Alpha (α)-E-catenin is a component of the cadherin complex, and has long been thought to provide a link between cell surface cadherins and the actin skeleton. More recently, it has also been implicated in mechano-sensing, and in the control of tissu
Externí odkaz:
https://doaj.org/article/227a6dc6f0db458883b86af568e7ae26