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CD8+ T cell responses in convalescent COVID-19 individuals target epitopes from the entire SARS-CoV-2 proteome and show kinetics of early differentiation.

Autor: Kared H; ImmunoScape Pte Ltd, Singapore., Redd AD; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Bloch EM; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Bonny TS; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Sumatoh H; ImmunoScape Pte Ltd, Singapore., Kairi F; ImmunoScape Pte Ltd, Singapore., Carbajo D; ImmunoScape Pte Ltd, Singapore., Abel B; ImmunoScape Pte Ltd, Singapore., Newell EW; ImmunoScape Pte Ltd, Singapore.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Bettinotti MP; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Benner SE; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Patel EU; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Littlefield K; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Laeyendecker O; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Shoham S; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Sullivan D; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Casadevall A; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Pekosz A; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Nardin A; ImmunoScape Pte Ltd, Singapore., Fehlings M; ImmunoScape Pte Ltd, Singapore., Tobian AA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Quinn TC; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2020 Oct 08. Date of Electronic Publication: 2020 Oct 08.