Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Sumati, Rajagopalan"'
Autor:
Xiaoxuan Zhuang, James Woods, Yanlong Ji, Sebastian Scheich, Fei Mo, Sumati Rajagopalan, Zana A. Coulibaly, Matthias Voss, Henning Urlaub, Louis M. Staudt, Kuan-Ting Pan, Eric O. Long
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114105- (2024)
Summary: Natural killer (NK) cells are primary defenders against cancer precursors, but cancer cells can persist by evading immune surveillance. To investigate the genetic mechanisms underlying this evasion, we perform a genome-wide CRISPR screen usi
Externí odkaz:
https://doaj.org/article/c794b7a102fe416caa29c2a724e04940
Autor:
Padmapriya Sekar, Sumati Rajagopalan, Estela Shabani, Usheer Kanjee, Marc A Schureck, Gunjan Arora, Mary E Peterson, Boubacar Traore, Peter D Crompton, Manoj T Duraisingh, Sanjay A Desai, Eric O Long
Publikováno v:
PLoS Pathogens, Vol 19, Iss 11, p e1011585 (2023)
Natural killer (NK) cells lyse virus-infected cells and transformed cells through polarized delivery of lytic effector molecules into target cells. We have shown that NK cells lyse Plasmodium falciparum-infected red blood cells (iRBC) via antibody-de
Externí odkaz:
https://doaj.org/article/aff072e252f94230992a43f271b45acd
Autor:
Malcolm J. W. Sim, Paul Brennan, Katherine L. Wahl, Jinghua Lu, Sumati Rajagopalan, Peter D. Sun, Eric O. Long
SummaryGenetic studies associate killer-cell immunoglobulin-like receptors (KIR) and their HLA class I ligands with a variety of human diseases. The basis for these associations, and the relative contribution of inhibitory and activating KIR to NK ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d827f88cf384cacca04290523917c8c6
https://doi.org/10.1101/2023.02.06.527249
https://doi.org/10.1101/2023.02.06.527249
Autor:
Gunjan Arora, Geoffrey T Hart, Javier Manzella-Lapeira, Justin YA Doritchamou, David L Narum, L Michael Thomas, Joseph Brzostowski, Sumati Rajagopalan, Ogobara K Doumbo, Boubacar Traore, Louis H Miller, Susan K Pierce, Patrick E Duffy, Peter D Crompton, Sanjay A Desai, Eric O Long
Publikováno v:
eLife, Vol 7 (2018)
Antibodies acquired naturally through repeated exposure to Plasmodium falciparum are essential in the control of blood-stage malaria. Antibody-dependent functions may include neutralization of parasite–host interactions, complement activation, and
Externí odkaz:
https://doaj.org/article/457a8813d81c4843847f41ab69e26c6a
Autor:
Michael J. Hollander, Eric O. Long, Sumati Rajagopalan, Erik L. Snapp, Olga M. Anton, Thomas A. Waldmann, K. Christopher Garcia, David W. Dorward, Mary E. Peterson, Javier Traba, Gunjan Arora
Publikováno v:
Proc Natl Acad Sci U S A
Interleukin 15 (IL-15) is an essential cytokine for the survival and proliferation of natural killer (NK) cells. IL-15 activates signaling by the β and common γ (γ(c)) chain heterodimer of the IL-2 receptor through trans-presentation by cells expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723102354a516a813fe7e3e54a66dd41
https://doi.org/10.1073/pnas.1911678117
https://doi.org/10.1073/pnas.1911678117
Autor:
Geoffrey T. Hart, Sumati Rajagopalan, Gunjan Arora, Peter D. Crompton, Yenan T. Bryceson, Tuan M. Tran, A. D. Jules Sangala, Boubacar Traore, Eric O. Long, Heinrich Schlums, Susan K. Pierce, Kerry J. Welsh, Jakob Theorell
Publikováno v:
Journal of Experimental Medicine. 216:1280-1290
How antibodies naturally acquired during Plasmodium falciparum infection provide clinical immunity to blood-stage malaria is unclear. We studied the function of natural killer (NK) cells in people living in a malaria-endemic region of Mali. Multi-par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d0c701102fe52bf2b1d2e7e4db08de4
https://doi.org/10.1084/jem.20181681
https://doi.org/10.1084/jem.20181681
Autor:
Jacqueline Moebius, Peter D. Crompton, Sumati Rajagopalan, Shanping Li, Rajan Guha, Gunjan Arora, Jeff Skinner, Kaveh Abdi, Mary E. Peterson, Eric O. Long, Boubacar Traore
Publikováno v:
Infect Immun
Natural killer (NK) cells are key effector cells of innate resistance capable of destroying tumors and virus-infected cells through cytotoxicity and rapid cytokine production. The control of NK cell responses is complex and only partially understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ea87613ddff873d3f01f332d106949
https://doi.org/10.1128/iai.00711-19
https://doi.org/10.1128/iai.00711-19
Autor:
Sumati Rajagopalan, Eric O. Long
Publikováno v:
Nature Digest. 16:32-34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44f1c667d95277ff44cd3fdecf09155c
https://doi.org/10.1038/ndigest.2019.190232
https://doi.org/10.1038/ndigest.2019.190232
Autor:
Sumati Rajagopalan, Yenan T Bryceson, Shanmuga P Kuppusamy, Daniel E Geraghty, Arnold van der Meer, Irma Joosten, Eric O Long
Publikováno v:
PLoS Biology, Vol 4, Iss 1, p e9 (2006)
Signaling from endosomes is emerging as a mechanism by which selected receptors provide sustained signals distinct from those generated at the plasma membrane. The activity of natural killer (NK) cells, which are important effectors of innate immunit
Externí odkaz:
https://doaj.org/article/e54f32fb549d46699a325cf193b2ed98
Autor:
Malcolm J W, Sim, Sumati, Rajagopalan, Daniel M, Altmann, Rosemary J, Boyton, Peter D, Sun, Eric O, Long
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(26)
Natural killer (NK) cells have an important role in immune defense against viruses and cancer. Activation of human NK cell cytotoxicity toward infected or tumor cells is regulated by killer cell immunoglobulin-like receptors (KIRs) that bind to human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3001cbc2ac4e87652a8b20262466f99c
https://pubmed.ncbi.nlm.nih.gov/31175150
https://pubmed.ncbi.nlm.nih.gov/31175150