Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sumana Ullas"'
Autor:
Laura Pitzonka, Sumana Ullas, Meenalakshmi Chinnam, Benjamin J Povinelli, Daniel T Fisher, Michelle Golding, Michelle M Appenheimer, Michael J Nemeth, Sharon Evans, David W Goodrich
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97628 (2014)
Co-transcriptionally assembled ribonucleoprotein (RNP) complexes are critical for RNA processing and nuclear export. RNPs have been hypothesized to contribute to the regulation of coordinated gene expression, and defects in RNP biogenesis contribute
Externí odkaz:
https://doaj.org/article/31c60bcf9a9443bcbc3e904fc7e03eef
Autor:
Darrell J. Irvine, Thorsten R. Mempel, Raif S. Geha, Sudha Kumari, Roderick T. Bronson, Jeroen M.J. Tas, Marcela Castillo-Rama, Erin Janssen, Shariq M. Usmani, Mira Tohme, Victor Barrera, Sumana Ullas
Publikováno v:
JCI Insight. 2
Patients deficient in the guanine nucleotide exchange factor DOCK8 have decreased numbers and impaired in vitro function of Tregs and make autoantibodies, but they seldom develop autoimmunity. We show that, similarly, Dock8–/– mice have decreased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60009b2cbc717075a91422a6c9c8df8
https://doi.org/10.1172/jci.insight.94298
https://doi.org/10.1172/jci.insight.94298
Autor:
Raif S. Geha, Katrina L. Randall, Christopher C. Goodnow, Sumana Ullas, Narayanaswamy Ramesh, Darrell J. Irvine, Hao Wu, Mira Tohme, Qi Qiao, Dianne Cox, Michel J. Massaad, Veronica Azcutia, Francis W. Luscinskas, Mona Hedayat, Marion Leick, Sudha Kumari, Erin Janssen, John H. Hartwig, Waleed Al-Herz
Publikováno v:
The Journal of clinical investigation. 126(10)
Wiskott-Aldrich syndrome (WAS) is associated with mutations in the WAS protein (WASp), which plays a critical role in the initiation of T cell receptor-driven (TCR-driven) actin polymerization. The clinical phenotype of WAS includes susceptibility to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3836db95230e1265c8eb020c871ce0ba
https://pubmed.ncbi.nlm.nih.gov/27599296
https://pubmed.ncbi.nlm.nih.gov/27599296
Autor:
Erin Janssen, Sumana Ullas, Haifa H. Jabara, Richard J. Bram, Tatyana Sannikova, Lennart Hammarström, John P. Manis, John Lee, Anthony C. Cruz, Richard Malley, Richard M. Siegel, Kyriaki Liadaki, Halli Benson, Raif S. Geha, Lilit Garibyan
Publikováno v:
Journal of Allergy and Clinical Immunology. 139:1293-1301.e4
Background The B-cell receptor transmembrane activator and calcium modulator ligand interactor (TACI) is important for T-independent antibody responses. One in 200 blood donors are heterozygous for the TACI A181E mutation. Objective We sought to inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c70d0a176576f76cd20c9b6caef937da
https://doi.org/10.1016/j.jaci.2016.07.028
https://doi.org/10.1016/j.jaci.2016.07.028
Autor:
Sevgi Keles, Laurence Menard, Gérard Lefranc, Raif S. Geha, Christopher Massad, Waleed Al-Herz, Eric Meffre, Helen C. Su, Sumana Ullas, Jason M. Bannock, Henner Morbach, Isil Barlan, Majed Dasouki, Talal A. Chatila, Erin Janssen
Publikováno v:
The Journal of allergy and clinical immunology. 134(6)
Background Dedicator of cytokinesis 8 (DOCK8) deficiency is typified by recurrent infections, increased serum IgE levels, eosinophilia, and a high incidence of allergic and autoimmune manifestations. Objective We sought to determine the role of DOCK8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64af0a191a84c40cd9c84453d0f15862
https://pubmed.ncbi.nlm.nih.gov/25218284
https://pubmed.ncbi.nlm.nih.gov/25218284
Autor:
Shizuo Akira, Katherine A. Fitzgerald, Esra Ozcan, Raif S. Geha, Kyriaki Liadaki, John P. Manis, Sumana Ullas, Douglas T. Golenbock, Erin Janssen, Haifa H. Jabara
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 192(6)
The TLR4 ligand LPS causes mouse B cells to undergo IgE and IgG1 isotype switching in the presence of IL-4. TLR4 activates two signaling pathways mediated by the adaptor molecules MyD88 and Toll/IL-IR domain-containing adapter-inducing IFN-β (TRIF)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5b782472bcda39efffe4b5e70938e4
https://pubmed.ncbi.nlm.nih.gov/24532577
https://pubmed.ncbi.nlm.nih.gov/24532577
Autor:
Sumana Ullas, Michael J. Nemeth, Michelle Golding, Laura Pitzonka, Sharon S. Evans, Daniel T. Fisher, David W. Goodrich, Michelle M. Appenheimer, Benjamin J. Povinelli, Meenalakshmi Chinnam
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97628 (2014)
PLoS ONE
PLoS ONE
Co-transcriptionally assembled ribonucleoprotein (RNP) complexes are critical for RNA processing and nuclear export. RNPs have been hypothesized to contribute to the regulation of coordinated gene expression, and defects in RNP biogenesis contribute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d3b03f4e874749c06949d8afdb7729
http://europepmc.org/articles/PMC4022742?pdf=render
http://europepmc.org/articles/PMC4022742?pdf=render
Publikováno v:
Molecular and cellular biology. 33(17)
RNA processing and transport are mediated by cotranscriptionally assembled ribonucleoprotein (RNP) complexes. RNPs have been postulated to help specify coordinated gene expression, but the requirements for specific RNP complexes in mammalian developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c235c5662115c200a5f85620cd8d0c7
https://pubmed.ncbi.nlm.nih.gov/23816884
https://pubmed.ncbi.nlm.nih.gov/23816884
Autor:
Erin Janssen, Esra Ozcan, Kyriaki Liadaki, Haifa Jabara, John Manis, Sumana Ullas, Shizuo Akira, Katherine Fitzgerald, Douglas Golenbock, Raif Geha
Publikováno v:
The Journal of Immunology. 192:62.8-62.8
The TLR4 ligand LPS causes mouse B cells to undergo IgE and IgG1 isotype switching in the presence of IL-4. TLR4 activates two signaling pathways mediated by the adaptor molecules MyD88 and TRAM, which recruits TRIF. Following stimulation with LPS+IL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8968ec250489de5b6d223de51b1e5522
https://doi.org/10.4049/jimmunol.192.supp.62.8
https://doi.org/10.4049/jimmunol.192.supp.62.8
Publikováno v:
Cancer Research. 73:5193-5193
Thoc1 encodes an RNA binding protein (Thoc1) which interacts with the tumor suppressor retinoblastoma (Rb1). Thoc1 levels have been found to be elevated in multiple cancers relative to normal tissue. Additionally cancer cells but not most normal cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa0e46148d299c4ff509770d9cb4f9b6
https://doi.org/10.1158/1538-7445.am2013-5193
https://doi.org/10.1158/1538-7445.am2013-5193