Comparison of Clinical Characteristics and Genetic Aberrations of Plasma Cell Disorders in Thailand Population

Autor: Chutirat Jirabanditsakul MSc, Sumana Dakeng PhD, Chutima Kunacheewa MD, Yaowalak U-pratya MSc, Weerapat Owattanapanich MD

Publikováno v: Technology in Cancer Research & Treatment, Vol 21 (2022)

Multiple myeloma is an incurable malignancy of plasma cells resulting from impaired terminal B cell development. Almost all patients with multiple myeloma eventually have a relapse. Many studies have demonstrated the importance of the various genomic

Externí odkaz: https://doaj.org/article/e4a0a7176b9f4cfdb88b11a57b0e00c0

The effectiveness of cucurbitacin B in BRCA1 defective breast cancer cells.

Autor: Moltira Promkan, Sumana Dakeng, Subhas Chakrabarty, Oliver Bögler, Pimpicha Patmasiriwat

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e55732 (2013)

Cucurbitacin B (CuB) is one of the potential agents for long term anticancer chemoprevention. Cumulative evidences has shown that cucurbitacin B provides potent cellular biological activities such as hepatoprotective, anti-inflammatory and antimicrob

Externí odkaz: https://doaj.org/article/8e2c8c844c2a4dff97695bd3ed4def9b

Cucurbitacin B Induces Hypermethylation of Oncogenes in Breast Cancer Cells

Autor: Apichart Suksamrarn, Kanthanadon Dittharot, Pimpicha Patmasiriwat, Parichat Suebsakwong, Sumana Dakeng, Moltira Promkan

Publikováno v: Planta medica. 85(5)

Breast cancer is a complex disease driven by multiple factors including both genetic and epigenetic alterations. Recent studies revealed that abnormal gene expression induced by epigenetic changes including aberrant promoter methylation plays a criti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05fcf71400a03cbebe359f1e17645bd5
https://pubmed.ncbi.nlm.nih.gov/30463098

Nuclear EGFRvIII-STAT5b complex contributes to glioblastoma cell survival by direct activation of the Bcl-XL promoter

Autor: Kenneth Aldape, Khatri Latha, Sumana Dakeng, Vaibhav Chumbalkar, Anupama E. Gururaj, Ming Li, Frank B. Furnari, Oliver Bogler, Webster K. Cavenee, Raymond Sawaya, YeoHyeon Hwang

Publikováno v: International Journal of Cancer. 132:509-520

Aberrant EGFR signaling strongly promotes glioma malignancy and treatment resistance. The most prevalent mutation, ΔEGFR/EGFRvIII, is an in-frame deletion of the extracellular domain, which occurs in more than 25% of glioblastomas and enhances growt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ef8d508160d1899ceb89b1afd21db8
https://doi.org/10.1002/ijc.27690

Antiproliferative Effects of Cucurbitacin B in Breast Cancer Cells: Down-Regulation of the c-Myc/hTERT/Telomerase Pathway and Obstruction of the Cell Cycle

Autor: Pimpicha Patmasiriwat, Suwit Duangmano, Sumana Dakeng, Duncan R. Smith, Apichart Suksamrarn, Weena Jiratchariyakul

Publikováno v: International Journal of Molecular Sciences, Vol 11, Iss 12, Pp 5323-5338 (2010)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 11; Issue 12; Pages: 5323-5338

Naturally occurring cucurbitacins have been shown to have anticancer, antimicrobial and anti-inflammatory activities. In this study, we determined the effects of cucurbitacin B extracted from the Thai herb Trichosanthes cucumerina L. on telomerase re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1eef0b7d6b1e5634c041652d80621f9
http://www.mdpi.com/1422-0067/11/12/5323/