Výsledky vyhledávání - "Suman K. Das"

ATP Citrate Lyase Improves Mitochondrial Function in Skeletal Muscle

Autor: David J. Glass, Mara Fornaro, Frederic Morvan, Suman K. Das, Viktor Meier, Gauthier Toussaint, Benjamin Jourde, Peter Kahle, Pascale Brebbia

Publikováno v: Cell Metabolism. 21:868-876

SummaryMitochondrial dysfunction is associated with skeletal muscle pathology, including cachexia, sarcopenia, and the muscular dystrophies. ATP citrate lyase (ACL) is a cytosolic enzyme that catalyzes mitochondria-derived citrate into oxaloacetate a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0b7b72dc367f8d83e74044eb23a7e3
https://doi.org/10.1016/j.cmet.2015.05.006

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Micro RNA-124a Regulates Lipolysis via Adipose Triglyceride Lipase and Comparative Gene Identification 58

Autor: Anna Schwarz, Paul Vesely, Silvia Schauer, Elke Stadelmeyer, Rudolf Zechner, Heimo Strohmaier, Gerald Hoefler, Thiery Claudel, Suman K. Das

Publikováno v: International Journal of Molecular Sciences, Vol 16, Iss 4, Pp 8555-8568 (2015)
International Journal of Molecular Sciences
Volume 16
Issue 4
Pages 8555-8568

Lipolysis is the biochemical pathway responsible for the catabolism of cellular triacylglycerol (TG). Lipolytic TG breakdown is a central metabolic process leading to the generation of free fatty acids (FA) and glycerol, thereby regulating lipid, as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c4f4a4a99e7b813fc73e8f7df7e74c
http://www.mdpi.com/1422-0067/16/4/8555

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A stress-induced early innate response causes multidrug tolerance in melanoma

Autor: Karin Wagner, Adina Vultur, Gao Zhang, Meenhard Herlyn, Suman K. Das, H.P. Soyer, Gerald Hoefler, Karl Kashofer, Brian Gabrielli, D. Ravindran Menon, Clemens Krepler, Rajasekharan Somasundaram, E. Bonyadi Rad, Silvia Schauer, Helmut Schaider, Nikolas K. Haass, Beate Rinner

Publikováno v: Oncogene. 34:4448-4459

Acquired drug resistance constitutes a major challenge for effective cancer therapies with melanoma being no exception. The dynamics leading to permanent resistance are poorly understood but are important to design better treatments. Here we show tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a20d56e4ef34952f4f68bddeb89d620a
https://doi.org/10.1038/onc.2014.372

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Effects of Lewis lung carcinoma and B16 melanoma on the innervation of the mouse trachea

Autor: Lars Wessels, Tilman Graulich, Christian Mühlfeld, Gerald Hoefler, Wolfgang Kummer, Suman K. Das

Publikováno v: Autonomic Neuroscience. 183:106-110

Cancer patients often suffer from dyspnea the pathogenesis of which is incompletely understood. Both dyspnea and pulmonary diseases are closely linked to airway innervation. Recently, it was shown that Lewis lung carcinoma induces cardiac hypoinnerva

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https://doi.org/10.1016/j.autneu.2014.03.005

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Identification of the transcription factor HOXB4 as a novel target of miR-23a

Autor: Suman K. Das, Ivo Leuschner, Karin Koller, Melanie Korbelius, Gerald Hoefler, Barbara Guertl

Publikováno v: Genes, Chromosomes and Cancer. 52:709-715

The transcription factor HOXB4 not only plays a role during nephrogenesis, but displays also oncogenic characteristics in different malignant neoplasms. An in-silico analysis revealed HOXB4 as a new target of microRNA-23a (miR-23a). Nephroblastomas a

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https://doi.org/10.1002/gcc.22066

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Cancer cachexia alters intracellular surfactant metabolism but not total alveolar surface area

Autor: Lars Wessels, Suman K. Das, Tilman Graulich, Christian Mühlfeld, Gerald Hoefler, Clemens Ruppert, Gabriela Krasteva

Publikováno v: Histochemistry and Cell Biology. 138:803-813

Dyspnoea is frequently observed in cancer cachectic patients. Little is known whether this is accompanied by structural or functional alterations of the lung. We hypothesized that in analogy to calorie restriction cancer cachexia leads to loss of alv

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https://doi.org/10.1007/s00418-012-0995-3

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Apoptosis and fibrosis are early features of heart failure in an animal model of metabolic cardiomyopathy

Autor: Dagmar Kratky, Gerald Hoefler, Barbara Gürtl, Christian Guelly, Lefeng Zhang, Gregor Gorkiewicz, Suman K. Das, Kuppusamy Palaniappan Tamilarasan

Publikováno v: International Journal of Experimental Pathology. 90:338-346

In previous experiments, we observed signs of cardiac failure in mice overexpressing lipoprotein lipase (LPL) under the control of a muscle specific promotor and in peroxisome proliferators activated receptor alpha (PPARα) knockout mice overexpressi

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https://doi.org/10.1111/j.1365-2613.2009.00647.x

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Genomewide bioinformatic analysis negates any specific role for Dof, GATA and Ag/cTCA motifs in nitrate responsive gene expression in Arabidopsis

Autor: Suman K. Das, Ravi Ramesh Pathak, Devapriya Choudhury, Nandula Raghuram

Publikováno v: Physiology and Molecular Biology of Plants. 15:145-150

Nitrate response at the plant level is mediated by the transcriptional regulation of several hundreds of genes, but no common cis-acting nitrate-responsive elements (NREs) have been identified so far. Earlier, we bioinformatically ruled out the possi

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https://doi.org/10.1007/s12298-009-0016-8

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