Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Suman Jayadev"'
Autor:
Peter Thomas, Manon Leclerc, Kira Evitts, Caitlin Brown, Wyatt Miller, Angela J. Hanson, William A. Banks, Laura Gibbons, Kimiko Domoto‐Reilly, Suman Jayadev, Ge Li, Elaine Peskind, Jessica E. Young, the Consortium for the early identification of Alzheimer's disease‐Quebec (CIMA‐Q), Frederic Calon, Elizabeth M. Rhea
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION Brain insulin resistance and deficiency is a consistent feature of Alzheimer's disease (AD). Insulin resistance can be mediated by the surface expression of the insulin receptor (IR). Cleavage of the IR generates the soluble IR
Externí odkaz:
https://doaj.org/article/a96035dfbb90424f8896334c2188590c
Autor:
Andrea DeBarber, Yaz Kisanuki, Paulo Nobrega, Ryan Himes, Suman Jayadev, John Bernat, Vikram Prakash, James Gibson, Austin Larson, Paulo Sgobbi, Edward Murphy, Brian Fedor, Cheryl Wong Po Foo, Rana Dutta, Michael Imperiale, Jolan Terner-Rosenthal, Will Garner, Pamela Vig, P. Barton Duell, Sarah Perez, Ritesh Ramdhani, Jonas Saute
Publikováno v:
Genetics in Medicine Open, Vol 2, Iss , Pp 101039- (2024)
Externí odkaz:
https://doaj.org/article/42357f5775fb45ad9cbb1f099d5a0e41
Autor:
Shannon E. Rose, C. Andrew Williams, Dale W. Hailey, Swati Mishra, Amanda Kirkland, C. Dirk Keene, Gwenn A. Garden, Suman Jayadev, Jessica E. Young
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2024)
Abnormal endo-lysosomal morphology is an early cytopathological feature of Alzheimer’s disease (AD) and genome-wide association studies (GWAS) have implicated genes involved in the endo-lysosomal network (ELN) as conferring increased risk for devel
Externí odkaz:
https://doaj.org/article/c0d5d4add48d4fdfb47207c220cc7ff6
Autor:
Macarena S. Aloi, Katherine E. Prater, Raymond E. A. Sánchez, Asad Beck, Jasmine L. Pathan, Stephanie Davidson, Angela Wilson, C. Dirk Keene, Horacio de la Iglesia, Suman Jayadev, Gwenn A. Garden
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-19 (2023)
Abstract Alzheimer’s Disease (AD) is characterized by the accumulation of extracellular amyloid-β (Aβ) as well as CNS and systemic inflammation. Microglia, the myeloid cells resident in the CNS, use microRNAs to rapidly respond to inflammatory si
Externí odkaz:
https://doaj.org/article/12e50782b5f14fdc92537e1a7d1abe77
Autor:
Rachael A. Batabyal, Ankush Bansal, Laura Reck Cechinel, Kayla Authelet, Madeleine Goldberg, Evan Nadler, C. Dirk Keene, Suman Jayadev, Kimiko Domoto-Reilly, Gail Li, Elaine Peskind, Kazue Hashimoto-Torii, Dedra Buchwald, Robert J. Freishtat
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 14024 (2023)
Alzheimer disease (AD) is characterized by amyloid-β (Aβ) plaques, neurofibrillary tangles, synaptic dysfunction, and progressive dementia. Midlife obesity increases the risk of developing AD. Adipocyte-derived small extracellular vesicles (ad-sEVs
Externí odkaz:
https://doaj.org/article/60c698ed24114e489bc9c848ef04acb2
Autor:
Sumit Mukherjee, Laura Heath, Christoph Preuss, Suman Jayadev, Gwenn A. Garden, Anna K. Greenwood, Solveig K. Sieberts, Philip L. De Jager, Nilüfer Ertekin-Taner, Gregory W. Carter, Lara M. Mangravite, Benjamin A. Logsdon
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The limited understanding of the temporal molecular changes in late-onset Alzheimer’s disease hinder the development of therapeutic treatment. The authors use manifold learning to develop a molecular model for disease progression from RNASeq data f
Externí odkaz:
https://doaj.org/article/467434a5e4e8458aa4f2642bf2e3f186
Autor:
Yi Su, Shaney Flores, Guoqiao Wang, Russ C. Hornbeck, Benjamin Speidel, Nelly Joseph‐Mathurin, Andrei G. Vlassenko, Brian A. Gordon, Robert A. Koeppe, William E. Klunk, Clifford R. Jack Jr., Martin R. Farlow, Stephen Salloway, Barbara J. Snider, Sarah B. Berman, Erik D. Roberson, Jared Brosch, Ivonne Jimenez‐Velazques, Christopher H. vanDyck, Douglas Galasko, Shauna H. Yuan, Suman Jayadev, Lawrence S. Honig, Serge Gauthier, Ging‐Yuek R. Hsiung, Mario Masellis, William S. Brooks, Michael Fulham, Roger Clarnette, Colin L. Masters, David Wallon, Didier Hannequin, Bruno Dubois, Jeremie Pariente, Raquel Sanchez‐Valle, Catherine Mummery, John M. Ringman, Michel Bottlaender, Gregory Klein, Smiljana Milosavljevic‐Ristic, Eric McDade, Chengjie Xiong, John C. Morris, Randall J. Bateman, Tammie L.S. Benzinger
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 180-190 (2019)
Abstract Introduction Quantitative in vivo measurement of brain amyloid burden is important for both research and clinical purposes. However, the existence of multiple imaging tracers presents challenges to the interpretation of such measurements. Th
Externí odkaz:
https://doaj.org/article/6e1734993f954447b3409ef075057895
Autor:
Caitlin S. Latimer, Bridget T. Burke, Nicole F. Liachko, Heather N. Currey, Mitchell D. Kilgore, Laura E. Gibbons, Jonathan Henriksen, Martin Darvas, Kimiko Domoto-Reilly, Suman Jayadev, Tom J. Grabowski, Paul K. Crane, Eric B. Larson, Brian C. Kraemer, Thomas D. Bird, C. Dirk Keene
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-24 (2019)
Abstract Alzheimer’s disease neuropathologic change (ADNC) is defined by progressive accumulation of β-amyloid plaques and hyperphosphorylated tau (pTau) neurofibrillary tangles across diverse regions of brain. Non-demented individuals who reach a
Externí odkaz:
https://doaj.org/article/bc0a491ce3824f00984ecbed34fa9ee7
Autor:
Allison Knupp, Swati Mishra, Refugio Martinez, Jacquelyn E. Braggin, Marcell Szabo, Chizuru Kinoshita, Dale W. Hailey, Scott A. Small, Suman Jayadev, Jessica E. Young
Publikováno v:
Cell Reports, Vol 31, Iss 9, Pp - (2020)
Summary: SORL1/SORLA is a sorting receptor involved in retromer-related endosomal traffic and an Alzheimer’s disease (AD) risk gene. Using CRISPR-Cas9, we deplete SORL1 in hiPSCs to ask if loss of SORL1 contributes to AD pathogenesis by endosome dy
Externí odkaz:
https://doaj.org/article/19746c1d19d847c3a60732df360c1e8c
Autor:
Megan Beckman, Kevin Knox, Zachery Koneval, Carole Smith, Suman Jayadev, Melissa Barker-Haliski
Publikováno v:
Neurobiology of Disease, Vol 136, Iss , Pp 104719- (2020)
Patients with Alzheimer's disease (AD) experience seizures at higher rates than the general population of that age, suggesting an underexplored role of hyperexcitability in AD. Genetic variants in presenilin (PSEN) 1 and 2 genes lead to autosomal dom
Externí odkaz:
https://doaj.org/article/284c38d1b5284df9a8008e7b75a1fdee