The role of N-terminal and C-terminal Arg residues from BK on interaction with kinin B2 receptor

Autor: Eliete S. Rodrigues, Laerte Oliveira, Suma I. Shimuta, Renan Paulo Martin, João Bosco Pesquero, Clovis R. Nakaie, Rafael Filippelli-Silva

Publikováno v: Biological Chemistry. 397:305-314

Bradykinin (BK) is a nonapeptide important for several physiological processes such as vasodilatation, increase in vascular permeability and release of inflammatory mediators. BK performs its actions by coupling to and activating the B2 receptor, a f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4cf4455f57ceeb3f83c4a2942e7785
https://doi.org/10.1515/hsz-2015-0221

Effects on Cell Viability and on Apoptosis in Tumoral (MCF-7) and in Normal (MCF10A) Epithelial Breast Cells after Human Chorionic Gonadotropin and Derivated-Angiotensin Peptides Treatments

Autor: Werica Bernardo, Suma I. Shimuta, Alexandre Jesus Barros, Clovis R. Nakaie, Ismael Dale Cotrim Guerreiro da Silva, Samuel Marcos Ribeiro de Noronha, Silvana Aparecida Alves Corrêa de Noronha

Publikováno v: Journal of Cancer Therapy. :65-69

Angiotensin-(1 - 7) [Ang-(1 - 7)] is an endogenous heptapeptide hormone of the renin-angiotensin system that has antiproliferative properties. The aim of this work was to evaluate the anti-proliferative and pro-apoptotic properties of Ang-(1 - 7) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f521033b583f059ac5b567cb01973384
https://doi.org/10.4236/jct.2013.47a010

Short peptide constructs mimic agonist sites of AT1R and BK receptors

Autor: Erick Fernando Poletti, Antonio C.M. Paiva, Douglas Duarte Lopes, Suma I. Shimuta, Laerte Oliveira, Renata F. F. Vieira, Luciana Malavolta, Clovis R. Nakaie, Shirley Schreier

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Extracellular peptide ligand binding sites, which bind the N-termini of angiotensin II (AngII) and bradykinin (BK) peptides, are located on the N-terminal and extracellular loop 3 regions of the AT(1)R and BKRB(1) or BKRB(2) G-protein-coupled recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c4dd402c70dcd82762739c7fd9d991
https://doi.org/10.1007/s00726-012-1405-9

Structural analysis of three peptides related to the transmambranic helix VI of AT1 receptor

Autor: Ismael Dale Cotrim Guerreiro da Silva, Suma I. Shimuta, Caroline Corrêa da Silva, Maurício L. Sforça, Douglas Duarte Lopes, Nilson Ivo Tonin Zanchin, Erick Fernando Poletti, Silvana Aparecida Alves Correa, Samuel Marcos Ribeiro de Noronha, Clovis R. Nakaie

Publikováno v: Neuropeptides. 44:115-118

Introduction Angiotensin II (AII) is the main active product of the renin angiotensin system. Better known effects of AII are via AT1 receptor (AT1R). Expression of AT1R mutants (L265D and L262D) in CHO cells increased cAMP formation when compared to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c04b58ba45151fc0b0ec802c571bedfe
https://doi.org/10.1016/j.npep.2009.11.006

Factors regulating tachyphylaxis triggered by N-terminal-modified angiotensin II analogs

Autor: Christian M. Ito, Fernando A.M. Cembranelli, Suma I. Shimuta, Laerte Oliveira, Alexandre Jesus Barros, Clovis R. Nakaie, Elaine N. Makino, Sinval E. G. Souza, Francisco C. Moraes

Publikováno v: bchm. 390:1265-1270

Binding of angiotensin II (DRVYIHPF, AngII) to its AT1 receptor can trigger a process known as tachyphylaxis (loss of receptor response owing to repeated agonist stimulation). We propose a two-state binding model for tachyphylaxis where the N-termina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690f27dcae723b9ae2b8343330e4a9d9
https://doi.org/10.1515/bc.2009.143