Discovery of (S)-1-((2′,6-Bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain

Autor: Guanglin Luo, Ling Chen, Walter A. Kostich, Brian Hamman, Jason Allen, Amy Easton, Clotilde Bourin, Michael Gulianello, Jonathan Lippy, Susheel Nara, Tarun Kumar Maishal, Kamalraj Thiyagarajan, Prasadrao Jalagam, Sreenivasulu Naidu Pattipati, Kumaran Dandapani, Manoj Dokania, Pradeep Vattikundala, Vivek Sharma, Saravanan Elavazhagan, Manoj Kumar Verma, Manish Lal Das, Santosh Wagh, Anand Balakrishnan, Benjamin M. Johnson, Kenneth S. Santone, George Thalody, Rex Denton, Hariharan Saminathan, Vinay K. Holenarsipur, Anoop Kumar, Abhijith Rao, Siva Prasad Putlur, Sarat Kumar Sarvasiddhi, Ganesh Shankar, Justin V. Louis, Manjunath Ramarao, Charles M. Conway, Yu-Wen Li, Rick Pieschl, Yuan Tian, Yang Hong, Jonathan Ditta, Arvind Mathur, Jianqing Li, Daniel Smith, Joseph Pawluczyk, Dawn Sun, Shiuhang Yip, Dauh-Rurng Wu, Muthalagu Vetrichelvan, Anuradha Gupta, Alan Wilson, Suma Gopinathan, Suman Wason, Linda Bristow, Charles F. Albright, Joanne J. Bronson, John E. Macor, Carolyn D. Dzierba

Publikováno v: Journal of Medicinal Chemistry. 65:4457-4480

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38224dcaf3d9ea2fabc4ac6df4a42a84
https://doi.org/10.1021/acs.jmedchem.1c02131

A naturalistic observation study of medication counseling practices at retail chain pharmacies

Autor: Soham D. Yande, Prajakta P. Masurkar, Suma Gopinathan, Sujit Sansgiry

Publikováno v: Pharmacy Practice, Vol 18, Iss 1, p 1696 (2020)

Objective: This study evaluated medication counseling procedures and trends at retail pharmacies in the Houston metropolitan area through a naturalistic observational study. Methods: A blinded cross-sectional observational study was conducted at r

Externí odkaz: https://doaj.org/article/0be51244e4e244d8ad8615f03bad97a5

Genetic deletion of Mst1 alters T cell function and protects against autoimmunity.

Autor: Konstantin V Salojin, Brian D Hamman, Wei Chun Chang, Kanchan G Jhaver, Amin Al-Shami, Jeannette Crisostomo, Carrie Wilkins, Ann Marie Digeorge-Foushee, Jason Allen, Nita Patel, Suma Gopinathan, Julia Zhou, Amr Nouraldeen, Theodore C Jessop, Jeffrey T Bagdanoff, David J Augeri, Robert Read, Peter Vogel, Jonathan Swaffield, Alan Wilson, Kenneth A Platt, Kenneth G Carson, Alan Main, Brian P Zambrowicz, Tamas Oravecz

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e98151 (2014)

Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking. The contribution of Mst1 to Ag-specific immune responses and a

Externí odkaz: https://doaj.org/article/1dff52e3692941429b8b20d7536589fd

A naturalistic observation study of medication counseling practices at retail chain pharmacies

Autor: P. Masurkar, Suma Gopinathan, Sujit S. Sansgiry, Soham D Yande

Publikováno v: Pharmacy Practice (Granada), Volume: 18, Issue: 1, Article number: 1696, Published: 27 APR 2020
Pharmacy Practice, Vol 18, Iss 1, p 1696 (2020)
Pharmacy Practice
Pharmacy Practice (Granada) v.18 n.1 2020
SciELO España. Revistas Científicas Españolas de Ciencias de la Salud
instname

Objective: This study evaluated medication counseling procedures and trends at retail pharmacies in the Houston metropolitan area through a naturalistic observational study. Methods: A blinded cross-sectional observational study was conducted at reta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5694916485469f7e49c710377512de4
http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1885-642X2020000100006&lng=en&tlng=en

Design, synthesis, and in vivo activity of novel inhibitors of delta-5 desaturase for the treatment of metabolic syndrome

Autor: Simon D.P. Baugh, Praveen K. Pabba, Joseph Barbosa, Eric Coulter, Urvi Desai, Jason P. Gay, Suma Gopinathan, Qiang Han, Rajee Hari, S. David Kimball, Huy V. Nguyen, Chi-You Ni, David R. Powell, Arian Smith, Kristen M. Terranova, Alan Wilson, Xuan-Chuan Yu, Victoria K. Lombardo

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 25:3836-3839

The synthesis, SAR, and in vivo activity of inhibitors of delta-5 desaturase are described. Ring-constraint of the initial series provided access to a variety of in vitro active chemotypes, from which the indazole was selected. Examples from the inda

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d3a2e8a2feeee1565ab9c579d48d8f
https://doi.org/10.1016/j.bmcl.2015.07.066