INBRX-120, a CD8α-targeted detuned IL-2 that selectively expands and activates tumoricidal effector cells for safe and durable in vivo responses.

Autor: Sulzmaier FJ; Inhibrx Inc, La Jolla, California, USA florian@inhibrx.com., Kern N; Inhibrx Inc, La Jolla, California, USA., Ahn SJ; Inhibrx Inc, La Jolla, California, USA., Polovina A; Inhibrx Inc, La Jolla, California, USA., Ho J; Inhibrx Inc, La Jolla, California, USA., Hussain A; Inhibrx Inc, La Jolla, California, USA., Cyprus G; Inhibrx Inc, La Jolla, California, USA., Macedo C; Inhibrx Inc, La Jolla, California, USA., Pandit R; Inhibrx Inc, La Jolla, California, USA., Crago W; Inhibrx Inc, La Jolla, California, USA., Rowell E; Inhibrx Inc, La Jolla, California, USA., Timmer JC; Inhibrx Inc, La Jolla, California, USA., Eckelman BP; Inhibrx Inc, La Jolla, California, USA.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2023 Jan; Vol. 11 (1).

Treatment of a mutant KRAS lung cancer cell line with polyisoprenylated cysteinyl amide inhibitors activates the MAPK pathway, inhibits cell migration and induces apoptosis.

Autor: Gregory, Matthew D.¹ (AUTHOR), Ofosu-Asante, Kweku¹ (AUTHOR), Lazarte, Jassy Mary S.¹ (AUTHOR), Puente, Pablo E.² (AUTHOR), Tawfeeq, Nada¹ (AUTHOR), Belony, Nadine³ (AUTHOR), Huang, Yong³ (AUTHOR), Offringa, Ite A.² (AUTHOR), Lamango, Nazarius S.¹ (AUTHOR) nazarius.lamango@famu.edu

Publikováno v: PLoS ONE. 10/22/2024, Vol. 19 Issue 10, p1-24. 24p.

Recycling machinery of integrin coupled with focal adhesion turnover via RAB11-UNC13D-FAK axis for migration of pancreatic cancer cells.

Autor: Duong, Van-Thanh¹ (AUTHOR), Ha, Mihyang² (AUTHOR), Kim, Jayoung³ (AUTHOR), Kim, Ji-Young¹ (AUTHOR), Park, Siyoung¹ (AUTHOR), Reshma, Khatun Mst¹ (AUTHOR), Han, Myoung-Eun¹ (AUTHOR), Lee, Dongjun³ (AUTHOR), Kim, Yun Hak^1,4 (AUTHOR), Oh, Sae-Ock¹ (AUTHOR) hedgehog@pusan.ac.kr

Publikováno v: Journal of Translational Medicine. 8/29/2024, Vol. 22 Issue 1, p1-19. 19p.

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy.

Autor: Diaz Osterman CJ; Department of Obstetrics, Gynecology and Reproductive Sciences, Moores UCSD Cancer Center, La Jolla, United States., Ozmadenci D; Department of Obstetrics, Gynecology and Reproductive Sciences, Moores UCSD Cancer Center, La Jolla, United States., Kleinschmidt EG; Department of Obstetrics, Gynecology and Reproductive Sciences, Moores UCSD Cancer Center, La Jolla, United States., Taylor KN; Department of Obstetrics, Gynecology and Reproductive Sciences, Moores UCSD Cancer Center, La Jolla, United States., Barrie AM; Department of Obstetrics, Gynecology and Reproductive Sciences, Moores UCSD Cancer Center, La Jolla, United States., Jiang S; Department of Obstetrics, Gynecology and Reproductive Sciences, Moores UCSD Cancer Center, La Jolla, United States., Bean LM; Department of Obstetrics, Gynecology and Reproductive Sciences, Moores UCSD Cancer Center, La Jolla, United States., Sulzmaier FJ; Department of Obstetrics, Gynecology and Reproductive Sciences, Moores UCSD Cancer Center, La Jolla, United States., Jean C; Department of Obstetrics, Gynecology and Reproductive Sciences, Moores UCSD Cancer Center, La Jolla, United States., Tancioni I; Department of Obstetrics, Gynecology and Reproductive Sciences, Moores UCSD Cancer Center, La Jolla, United States., Anderson K; Department of Obstetrics, Gynecology and Reproductive Sciences, Moores UCSD Cancer Center, La Jolla, United States., Uryu S; Department of Obstetrics, Gynecology and Reproductive Sciences, Moores UCSD Cancer Center, La Jolla, United States., Cordasco EA; Department of Obstetrics, Gynecology and Reproductive Sciences, Moores UCSD Cancer Center, La Jolla, United States., Li J; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cellular Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Chen XL; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cellular Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Fu G; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cellular Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Ojalill M; Department of Biochemistry, University of Turku, Turku, Finland., Rappu P; Department of Biochemistry, University of Turku, Turku, Finland., Heino J; Department of Biochemistry, University of Turku, Turku, Finland., Mark AM; Department of Medicine, UCSD Center for Computational Biology & Bioinformatics, La Jolla, United States., Xu G; Department of Medicine, UCSD Center for Computational Biology & Bioinformatics, La Jolla, United States., Fisch KM; Department of Medicine, UCSD Center for Computational Biology & Bioinformatics, La Jolla, United States., Kolev VN; Verastem Oncology, Needham, United States., Weaver DT; Verastem Oncology, Needham, United States., Pachter JA; Verastem Oncology, Needham, United States., Győrffy B; Institute of Enzymology, Hungarian Academy of Sciences, Budapest, Hungary.; 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary., McHale MT; Department of Obstetrics, Gynecology and Reproductive Sciences, Moores UCSD Cancer Center, La Jolla, United States., Connolly DC; Fox Chase Cancer Center, Philadelphia, United States., Molinolo A; Department of Pathology, Moores UCSD Cancer Center, La Jolla, United States., Stupack DG; Department of Obstetrics, Gynecology and Reproductive Sciences, Moores UCSD Cancer Center, La Jolla, United States., Schlaepfer DD; Department of Obstetrics, Gynecology and Reproductive Sciences, Moores UCSD Cancer Center, La Jolla, United States.

Publikováno v: ELife [Elife] 2019 Sep 03; Vol. 8. Date of Electronic Publication: 2019 Sep 03.

CRISPRi screen of long non-coding RNAs identifies LINC03045 regulating glioblastoma invasion.

Autor: Tsung, Kathleen¹ (AUTHOR), Liu, Kristie Q.¹ (AUTHOR) kqliu@usc.edu, Han, Jane S.¹ (AUTHOR), Deshpande, Krutika¹ (AUTHOR), Doan, Tammy² (AUTHOR), Loh, Yong-Hwee Eddie³ (AUTHOR), Ding, Li⁴ (AUTHOR), Yang, Wentao² (AUTHOR), Neman, Josh⁵ (AUTHOR), Dou, Yali^2,6 (AUTHOR), Attenello, Frank J.^1,2 (AUTHOR)

Publikováno v: PLoS Genetics. 6/10/2024, Vol. 20 Issue 6, p1-26. 26p.