Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sultana Mehbuba Hossain"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7252 (2024)
Immune checkpoint inhibitors (ICIs) demonstrate durable responses, long-term survival benefits, and improved outcomes in cancer patients compared to chemotherapy. However, the majority of cancer patients do not respond to ICIs, and a high proportion
Externí odkaz:
https://doaj.org/article/606058c0bf0843b99d1bbac9286229ca
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6730 (2024)
Renal cell carcinoma (RCC) is a significant oncological challenge due to its heterogeneous nature and limited treatment options. The PAX developmental gene family encodes nine highly conserved transcription factors that play crucial roles in embryoni
Externí odkaz:
https://doaj.org/article/4ab6d1c43f314f6ab485fa4109a7cad5
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11432 (2023)
Renal cell carcinoma (RCC) is the most common form of kidney cancer, consisting of multiple distinct subtypes. RCC has the highest mortality rate amongst the urogenital cancers, with kidney renal clear cell carcinoma (KIRC), kidney renal papillary ce
Externí odkaz:
https://doaj.org/article/dcba54cc58c742668963bc9ac727b34b
Autor:
Sultana Mehbuba Hossain, Gregory Gimenez, Peter A. Stockwell, Peter Tsai, Cristin G. Print, Janusz Rys, Bozena Cybulska-Stopa, Magda Ratajska, Agnieszka Harazin-Lechowska, Suzan Almomani, Christopher Jackson, Aniruddha Chatterjee, Michael R. Eccles
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Melanoma is a highly aggressive skin cancer, which, although highly immunogenic, frequently escapes the body’s immune defences. Immune checkpoint inhibitors (ICI), such as anti-PD1, anti-PDL1, and anti-CTLA4 antibodies lead to reactivation of immun
Externí odkaz:
https://doaj.org/article/3a823aa5363644c89dd26356837eee0b
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1601 (2023)
Melanoma, a highly heterogeneous tumor, is comprised of a functionally diverse spectrum of cell phenotypes and subpopulations, including stromal cells in the tumor microenvironment (TME). Melanoma has been shown to dynamically shift between different
Externí odkaz:
https://doaj.org/article/e33542351e0a4b77abf29e63b712455b
Autor:
Shakil Ahmed, Andreas Kreft, Ezharul Hoque Chowdhury, Sultana Mehbuba Hossain, Peter R Galle, Helmut Neumann
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0239814 (2020)
Background and study aimsDespite major technical advancements, endoscopic surveillance for detecting premalignant lesions in Barrett's esophagus is challenging because of their flat appearance with only subtle morphological changes. Molecular endosco
Externí odkaz:
https://doaj.org/article/07a24be8603240c991513cd0749f35d2
Autor:
Sultana Mehbuba Hossain, Chiemi F. Lynch-Sutherland, Aniruddha Chatterjee, Erin C. Macaulay, Michael R. Eccles
Publikováno v:
Epigenomes, Vol 5, Iss 3, p 16 (2021)
Cancer is the second leading cause of mortality and morbidity in the developed world. Cancer progression involves genetic and epigenetic alterations, accompanied by aggressive changes, such as increased immune evasion, onset of metastasis, and drug r
Externí odkaz:
https://doaj.org/article/f781949829324c42894dcefa63cdfee6
Autor:
Lorissa I. McDougall, Ryan M. Powell, Magdalena Ratajska, Chi F. Lynch-Sutherland, Sultana Mehbuba Hossain, George A. R. Wiggins, Agnieszka Harazin-Lechowska, Bożena Cybulska-Stopa, Jyoti Motwani, Erin C. Macaulay, Glen Reid, Logan C. Walker, Janusz Ryś, Michael R. Eccles
Publikováno v:
Genes, Vol 12, Iss 2, p 320 (2021)
Melanoma comprises BARD1 splice isoforms in melanoma cell lines and patient tissue samples. Seventy-six BARD1 mRNA variants were identified in total, with several previously characterised isoforms (γ, φ, δ, ε, and η) contributing to a large prop
Externí odkaz:
https://doaj.org/article/61d7cbb9ba684ae8b87d221159744bbc
Publikováno v:
Cancers, Vol 12, Iss 1, p 161 (2020)
The morphology, size, and surface area of nanoparticles (NPs), with the existence of functional groups on their surface, contribute to the drug binding affinity, distribution of the payload in different organs, and targeting of a particular tumor for
Externí odkaz:
https://doaj.org/article/36a1e5e494d24a279d9c4b1259ae03f4
Publikováno v:
Biomedicines, Vol 7, Iss 1, p 4 (2019)
AZ628 is a hydrophobic Raf-kinase inhibitor (rapidly accelerated fibrosarcoma) currently in clinical trial of various cancer. The physicochemical properties of hydrophobic drugs that affect the drug-particle interactions and cause aggregation of drug
Externí odkaz:
https://doaj.org/article/0338a90d72be4c69b358455a0c14af18