Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue

Autor: Gonzalez-Perez Maria, O'Connell Olivia, Lin Rongheng, Sullivan W Matthew, Bell Jeanne, Simmonds Peter, Clapham Paul R

Publikováno v: Retrovirology, Vol 9, Iss 1, p 20 (2012)

Abstract Background Transmitted HIV-1 clade B or C R5 viruses have been reported to infect macrophages inefficiently, while other studies have described R5 viruses in late disease with either an enhanced macrophage-tropism or carrying envelopes with

Externí odkaz: https://doaj.org/article/c8f8506985ca4fb890b28e31a47e23d0

Variation in HIV-I R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors

Autor: Peters, Paul J., Duenas-Decamp, Maria J., Sullivan, W. Matthew, Brown, Richard, Ankghuambom, Chiambah, Luzuriaga, Katherine, Robinson, James, Burton, Dennis R., Bell, Jeanne, Simmonds, Peter, Ball, Jonathan, Clapham, Paul R.

Publikováno v: Peters, P J, Duenas-Decamp, M J, Sullivan, W M, Brown, R, Ankghuambom, C, Luzuriaga, K, Robinson, J, Burton, D R, Bell, J, Simmonds, P, Ball, J & Clapham, P R 2008, ' Variation in HIV-I R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors ', Retrovirology, vol. 5, 5, pp.-. https://doi.org/10.1186/1742-4690-5-5

Background: HIV-I R5 viruses cause most of the AIDS cases worldwide and are preferentially transmitted compared to CXCR4-using viruses. Furthermore, R5 viruses vary extensively in capacity to infect macrophages and highly macrophage-tropic variants a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::01f3be3745a2286bf2e969c4593839c2
https://www.pure.ed.ac.uk/ws/files/8550762/Variation_in_HIV_1_R5_macrophage_tropism_correlates_with_sensitivity_to_reagents_that_block_envelope_CD4_interactions_but_not_with_sensitivity_to_other_entry_inhibitors.pdf

Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors.

Autor: Peters, Paul J., Duenas-Decamp, Maria J., Sullivan, W. Matthew, Brown, Richard, Ankghuambom, Chiambah, Luzuriaga, Katherine, Robinson, James, Burton, Dennis R., Bell, Jeanne, Simmonds, Peter, Ball, Jonathan, Clapham, Paul R.

Publikováno v: Retrovirology; 2008, Vol. 5, Special section p1-17, 17p, 4 Charts, 7 Graphs