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Akademický článek

Mild SARS-CoV-2 infection results in long-lasting microbiota instability

Autor: Vaibhav Upadhyay, Rahul K. Suryawanshi, Preston Tasoff, Maria McCavitt-Malvido, Renuka G. Kumar, Victoria Wong Murray, Cecilia Noecker, Jordan E. Bisanz, Yulin Hswen, Connie W. Y. Ha, Bharath Sreekumar, Irene P. Chen, Susan V. Lynch, Melanie Ott, Sulggi Lee, Peter J. Turnbaugh

Publikováno v: mBio, Vol 14, Iss 4 (2023)

ABSTRACT Viruses targeting mammalian cells can indirectly alter the gut microbiota, potentially compounding their phenotypic effects. Multiple studies have observed a disrupted gut microbiota in severe cases of severe acute respiratory syndrome coron

Externí odkaz: https://doaj.org/article/a45091a010d74e58ac18fab5c99276e3

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Akademický článek

SARS-CoV-2-Specific T Cells Exhibit Phenotypic Features of Helper Function, Lack of Terminal Differentiation, and High Proliferation Potential

Autor: Jason Neidleman, Xiaoyu Luo, Julie Frouard, Guorui Xie, Gurjot Gill, Ellen S. Stein, Matthew McGregor, Tongcui Ma, Ashley F. George, Astrid Kosters, Warner C. Greene, Joshua Vasquez, Eliver Ghosn, Sulggi Lee, Nadia R. Roan

Publikováno v: Cell Reports Medicine, Vol 1, Iss 6, Pp 100081- (2020)

Summary: Convalescing coronavirus disease 2019 (COVID-19) patients mount robust T cell responses against SARS-CoV-2, suggesting an important role of T cells in viral clearance. To date, the phenotypes of SARS-CoV-2-specific T cells remain poorly defi

Externí odkaz: https://doaj.org/article/a72f1c6b4feb4f37be67cf2c5c77d4e5

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Akademický článek

Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection.

Autor: Feng Hsiao, Julie Frouard, Andrea Gramatica, Guorui Xie, Sushama Telwatte, Guinevere Q Lee, Pavitra Roychoudhury, Roland Schwarzer, Xiaoyu Luo, Steven A Yukl, Sulggi Lee, Rebecca Hoh, Steven G Deeks, R Brad Jones, Marielle Cavrois, Warner C Greene, Nadia R Roan

Publikováno v: PLoS Pathogens, Vol 16, Iss 4, p e1008450 (2020)

The primary reservoir for HIV is within memory CD4+ T cells residing within tissues, yet the features that make some of these cells more susceptible than others to infection by HIV is not well understood. Recent studies demonstrated that CCR5-tropic

Externí odkaz: https://doaj.org/article/1934c3830da24029845624b61301225f

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Akademický článek

Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency.

Autor: Sushama Telwatte, Sulggi Lee, Ma Somsouk, Hiroyu Hatano, Christopher Baker, Philipp Kaiser, Peggy Kim, Tsui-Hua Chen, Jeffrey Milush, Peter W Hunt, Steven G Deeks, Joseph K Wong, Steven A Yukl

Publikováno v: PLoS Pathogens, Vol 14, Iss 11, p e1007357 (2018)

Latently-infected CD4+ T cells are widely considered to be the major barrier to a cure for HIV. Much of our understanding of HIV latency comes from latency models and blood cells, but most HIV-infected cells reside in lymphoid tissues such as the gut

Externí odkaz: https://doaj.org/article/1a440fcf1d54452abd849ac695158099

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