Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides

Autor: Jeremy E. Turnbull, Rebecca L. Miller, Kevin Pagel, Johanna Hofmann, Scott E. Guimond, Jian Liu, Yongmei Xu, Olga V. Zubkova, Márkó Grabarics, Weston B. Struwe, Peter C. Tyler, Christian Manz, Niclas G. Karlsson, Geert-Jan Boons, Pradeep Chopra, Ralf Schwörer

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications, 11(1). Nature Publishing Group
Nature communications
Miller, R L, Guimond, S E, Schwörer, R, Zubkova, O V, Tyler, P C, Xu, Y, Liu, J, Chopra, P, Boons, G-J, Grabarics, M, Manz, C, Hofmann, J, Karlsson, N G, Turnbull, J E, Struwe, W B & Pagel, K 2020, ' Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides ', Nature Communications, vol. 11, no. 1, 1481 . https://doi.org/10.1038/s41467-020-15284-y

Despite evident regulatory roles of heparan sulfate (HS) saccharides in numerous biological processes, definitive information on the bioactive sequences of these polymers is lacking, with only a handful of natural structures sequenced to date. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f920e85f68e62045bd2b08b912e7a3af
https://doaj.org/article/771c43443fb14659b5131577553e2f14

Subendothelial heparan sulfate proteoglycans become major L-selectin and monocyte chemoattractant protein-1 ligands upon renal ischemia/reperfusion

Autor: Sandrine Florquin, Taina Pihlajaniemi, Robert H. J. Beelen, Sonja Zweegman, Eelco D. Keuning, Jacob van den Born, Johanna W.A.M. Celie, Angelika M. Dräger, Ritva Heljasvaara, Raija Soininen, Niels W.P. Rutjes, Jan Aten, Floortje L. Kessler

Publikováno v: Celie, J W A M, Rutjes, N W P, Keuning, E D, Soininen, R, Heljasvaara, R, Pihlajaniemi, T, Dräger, A M, Zweegman, S, Kessler, F L, Beelen, R H J, Florquin, S, Aten, J & Van Den Born, J 2007, ' Subendothelial heparan sulfate proteoglycans become major L-selectin and monocyte chemoattractant protein-1 ligands upon renal ischemia/reperfusion ', American Journal of Pathology, vol. 170, no. 6, pp. 1865-1878 . https://doi.org/10.2353/ajpath.2007.070061
American Journal of Pathology, 170(6), 1865-1878. Elsevier Inc.
The American Journal of Pathology, 170(6), 1865-1878. ELSEVIER SCIENCE INC
American journal of pathology, 170(6), 1865-1878. Elsevier Inc.

Leukocyte infiltration into inflamed tissues is considered to involve sequential steps of rolling over the endothelium, adhesion, and transmigration. In this model, the leukocyte adhesion molecule L-selectin and its ligands expressed on inflamed endo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9ff16f22f5cc775d335ee40e80e34aa
https://research.vumc.nl/en/publications/fe962e4a-ecec-48c3-961d-b9a3118307f5