Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Sulfones/pharmacology"'
Autor:
Jost, Marco, Chen, Yuwen, Gilbert, Luke A, Horlbeck, Max A, Krenning, Lenno, Menchon, Grégory, Rai, Ankit, Cho, Min Y, Stern, Jacob J, Prota, Andrea E, Kampmann, Martin, Akhmanova, Anna, Steinmetz, Michel O, Tanenbaum, Marvin E, Weissman, Jonathan S, Sub Cell Biology, Celbiologie
Publikováno v:
Molecular Cell
Molecular Cell, 79(1), 191. Cell Press
Molecular Cell, 79(1), 191-198.e3. Cell Press
Molecular Cell, 79(1), 191. Cell Press
Molecular Cell, 79(1), 191-198.e3. Cell Press
Pharmaceutical-grade rigosertib destabilizes microtubules in cells and in vitro, and expression of a tubulin variant with a mutation in the rigosertib-binding pocket allows cells to proliferate in the presence of rigosertib. Thus, pharmaceutical-grad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e69dbc0caaaee2c44b7494dfd72fa4
https://pubmed.ncbi.nlm.nih.gov/32619469
https://pubmed.ncbi.nlm.nih.gov/32619469
Autor:
Henrik Kold-Petersen, Ninna C. S. Voss, Casper Homilius, Ebbe Boedtkjer, Mikkel B. Henningsen
Publikováno v:
Voss, N C S, Kold-Petersen, H H, Henningsen, M B, Homilius, C & Boedtkjer, E 2019, ' Upregulated Na + /H +-exchange protects human colon cancer tissue against intracellular acidification ', BioMed Research International, vol. 2019, 3702783 . https://doi.org/10.1155/2019/3702783
BioMed Research International
BioMed Research International, Vol 2019 (2019)
BioMed Research International
BioMed Research International, Vol 2019 (2019)
Increased metabolism accelerates local acid production in cancer tissue. The mechanisms eliminating acidic waste products from human colon cancer tissue represent promising therapeutic targets for pharmacological manipulation in order to improve prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100bf714c00d6aa3a98379d7784224cf
https://pure.au.dk/portal/da/publications/upregulated-nahexchange-protects-human-colon-cancer-tissue-against-intracellular-acidification(08df03a6-f0bc-4f85-9e91-5d4daf27a06f).html
https://pure.au.dk/portal/da/publications/upregulated-nahexchange-protects-human-colon-cancer-tissue-against-intracellular-acidification(08df03a6-f0bc-4f85-9e91-5d4daf27a06f).html
Publikováno v:
British Journal of Pharmacology, Vol. 156, No 8 (2009) pp. 1296-1304
BACKGROUND AND PURPOSE: Amiloride derivatives are blockers of the Na(+)/H(+) exchanger (NHE) and at micromolar concentrations have protective effects on cardiac and brain ischaemia/reperfusion injury but at higher concentrations also induce apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::eda0cf26c0e45c533b0172dbe17fb0ad
https://archive-ouverte.unige.ch/unige:20019
https://archive-ouverte.unige.ch/unige:20019
Autor:
Dimitriadis, F., Giannakis, D., Pardalidis, N., Zikopoulos, K., Paraskevaidis, E., Giotitsas, N., Kalaboki, V., Tsounapi, P., Baltogiannis, D., Georgiou, I., Saito, M., Watanabe, T., Miyagawa, I., Sofikitis, N.
The aim of this review study is to elucidate the effects that phosphodiesterase 5 (PDE5) inhibitors exert on spermatozoa motility, capacitation process and on their ability to fertilize the oocyte. Second messenger systems such as the cAMP/adenylate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_____10561::05ec5c85c9f260ddb2bde26b9548be12
http://olympias.lib.uoi.gr/jspui/handle/123456789/22068
http://olympias.lib.uoi.gr/jspui/handle/123456789/22068
Autor:
Hi Chul Kim, Sungyong Jung, Auguste Genovesio, Ulf Nehrbass, Brigitte David-Watine, Neil Emans, Nam Youl Kim, Yong-Jun Kwon
Publikováno v:
Journal of Biomolecular Screening
Journal of Biomolecular Screening, 2007, 12 (5), pp.621-627. ⟨10.1177/1087057107301319⟩
Journal of Biomolecular Screening, SAGE Publications, 2007, 12 (5), pp.621-627. ⟨10.1177/1087057107301319⟩
Journal of Biomolecular Screening, 2007, 12 (5), pp.621-627. ⟨10.1177/1087057107301319⟩
Journal of Biomolecular Screening, SAGE Publications, 2007, 12 (5), pp.621-627. ⟨10.1177/1087057107301319⟩
Transcription factors of the nuclear factor κ B family are the paradigm for signaling dependent nuclear translocation and are ideally suited to analysis through image-based chemical genetic screening. The authors describe combining high-content imag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04185305487563cc4986d45255f3060
https://pubmed.ncbi.nlm.nih.gov/17507639
https://pubmed.ncbi.nlm.nih.gov/17507639
Autor:
Carine Fähndrich, Frank Ruschitzka, Alexander Akhmedov, Felix C. Tanner, Jan Steffel, Thomas F. Lüscher
In endothelial cells (EC), celecoxib inhibits expression of tissue factor (TF), a key protein for initiation and propagation of thrombus formation. The current study was designed to examine the effect of celecoxib on TF expression and activity in VSM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66437755de680512a35de4b6f9f49d9f
https://doi.org/10.5167/uzh-36617
https://doi.org/10.5167/uzh-36617
Autor:
Jean-Claude Irminger, Dominique G. Rouiller, Philippe A. Halban, Géraldine Parnaud, Domenico Bosco, Katharina Rickenbach, Pascale Ribaux, Eva Hammar
Publikováno v:
Journal of Biological Chemistry, Vol. 280, No 34 (2005) pp. 30630-30637
Laminin-5-rich extracellular matrix derived from 804G cells (804G-ECM) engages beta1 integrins to induce spreading, improve glucose-stimulated insulin secretion (GSIS), and increase survival of pancreatic beta cells. The present study examines whethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09318b5da2dd66f413ba4c37a8794f0c
https://archive-ouverte.unige.ch/unige:8794
https://archive-ouverte.unige.ch/unige:8794
Publikováno v:
Biological Chemistry, Vol. 380, No 11 (1999) pp. 1341-5
The budding yeastSaccharomyces cerevisiaehas been used extensively as a biological ‘test tube’ to study the regulation of the human estrogen receptor (ER) α. However, anti-estrogens, which are of great importance as therapeutic agents and resear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef04d2f2f4233902b4e38c9e4714882
https://archive-ouverte.unige.ch/unige:4632
https://archive-ouverte.unige.ch/unige:4632
Autor:
Gergely Albu, Fabienne Fontao, Ferenc Peták, Maurice Beghetti, Britta S. von Ungern-Sternberg, Tibor Z. Jánosi, Walid Habre
Publikováno v:
Respiratory Research
Respiratory Research, Vol. 12 (2011) P. 58
Respiratory Research, Vol 12, Iss 1, p 58 (2011)
Respiratory Research, Vol. 12 (2011) P. 58
Respiratory Research, Vol 12, Iss 1, p 58 (2011)
Background: The development of bronchial hyperreactivity (BHR) subsequent to precapillary pulmonary hypertension (PHT) was prevented by acting on the major signalling pathways (endothelin, nitric oxide, vasoactive intestine peptide (VIP) and prostacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f79a32aa04cb105934b1552840a7d5
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