Zobrazeno 1 - 10
of 233
pro vyhledávání: '"Sulfonamides/pharmacology"'
Autor:
Marta Gil-Ortega, Beatriz Somoza, María S. Fernández-Alfonso, Marta Viana, M. Paz Lorenzo, Martín Alcalá, Thomas Unger, Raquel González-Blázquez, William A. Boisvert, Ulrike Muscha Steckelings
Publikováno v:
González-Blázquez, R, Alcalá, M, Fernández-Alfonso, M S, Steckelings, U M, Lorenzo, M P, Viana, M, Boisvert, W, Unger, T, Ortega, M G & Somoza, B 2021, ' C21 preserves endothelial function in the thoracic aorta from DIO mice : role for AT2, Mas and B2 receptors ', Clinical Science, vol. 135, no. 9, pp. 1145-1163 . https://doi.org/10.1042/CS20210049
Clinical Science, 135(9), 1145-1163. Portland Press Ltd.
Clinical Science, 135(9), 1145-1163. Portland Press Ltd.
Compound 21 (C21), a selective agonist of angiotensin II type 2 receptor (AT2R), induces vasodilation through NO release. Since AT2R seems to be overexpressed in obesity, we hypothesize that C21 prevents the development of obesity-related vascular al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877a98634f9c9ee846c5eeeae1f14062
https://portal.findresearcher.sdu.dk/da/publications/d3fcf2be-7770-4967-9d40-5384bb58c9fe
https://portal.findresearcher.sdu.dk/da/publications/d3fcf2be-7770-4967-9d40-5384bb58c9fe
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Antimitotic drugs arrest cells in mitosis through chronic activation of the spindle assembly checkpoint (SAC), leading to cell death. However, drug-treated cancer cells can escape death by undergoing mitotic slippage, due to premature mitotic exit. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65669c7d34d09c189b5e66595f1fe50
https://pubmed.ncbi.nlm.nih.gov/33603057
https://pubmed.ncbi.nlm.nih.gov/33603057
Publikováno v:
Mendes, J T, Balogh, E A, Strowd, L C & Feldman, S R 2020, ' An evaluation of baricitinib as a therapeutic option for adult patients with moderate to severe atopic dermatitis ', Expert Opinion on Pharmacotherapy, vol. 21, no. 9, pp. 1027-1033 . https://doi.org/10.1080/14656566.2020.1739268
Introduction: Moderate-to-severe AD burdens a large proportion of AD patients and may represent an inadequacy of treatment options available for resistant disease. Areas covered: This review provides an overview of the therapies for moderate-to-sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f291ec244b6114736e8ddeabf606a63
https://portal.findresearcher.sdu.dk/da/publications/aeea7a82-7686-430a-b268-94f954ea916a
https://portal.findresearcher.sdu.dk/da/publications/aeea7a82-7686-430a-b268-94f954ea916a
Autor:
Mohammad Krayem, Catherine Sibille, Ghanem Elias Ghanem, Ahmad Awada, Murielle Wiedig, Ahmad Najem, Renato Morandini, Fabrice Journe, Jean-Christophe Marine, François Sales, Léon C van Kempen
Publikováno v:
European Journal of Cancer, 55, 98-110. ELSEVIER SCI LTD
Intrinsic and acquired resistance of metastatic melanoma to (V600E/K)BRAF and/or MEK inhibitors, which is often caused by activation of the PI3K/AKT survival pathway, represents a major clinical challenge. Given that p53 is capable of antagonising PI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a1e6bf491fe46c36749c7331f715ee
https://doi.org/10.1016/j.ejca.2015.12.002
https://doi.org/10.1016/j.ejca.2015.12.002
Autor:
Monica C. Dobocan, Filippa Pettersson, Christophe Goncalves, Marie-Noël M’Boutchou, Michael S. Dahabieh, Sonia V. del Rincón, Léon C van Kempen, Arjuna Rajakumar, Ivan Topisirovic, Wilson H. Miller, Shiru L. Lucy, Yao Zhan
Publikováno v:
Journal of Investigative Dermatology, 135(5), 1368-1376. ELSEVIER SCIENCE INC
In eukaryotic cells, the rate-limiting component for cap-dependent mRNA translation is the translation initiation factor eIF4E. eIF4E is overexpressed in a variety of human malignancies, but whether it has a role in melanoma remains obscure. We hypot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1754d4e7cfa6e6d5c25ab6516884520c
Autor:
Sandrine Belouzard, Jens Bukh, Lucie Fénéant, Priscille Brodin, Yves Rouillé, Jean Dubuisson, Laura Riva, Thomas F. Baumert, Alexandre Vandeputte, François Helle, Jannick Prentoe, Laurent L'homme, Laurence Cocquerel, Charles-Henry Gattolliat, Ok-Ryul Song, Tarik Asselah
Publikováno v:
Journal of Virology
Journal of Virology, 2018, 92 (10), pp.e01982-17. ⟨10.1128/JVI.01982-17⟩
Journal of Virology, American Society for Microbiology, 2018, 92 (10), pp.e01982-17. ⟨10.1128/JVI.01982-17⟩
Journal of Virology, 2018, 92 (10), pp.e01982-17. ⟨10.1128/JVI.01982-17⟩
Journal of Virology, American Society for Microbiology, 2018, 92 (10), pp.e01982-17. ⟨10.1128/JVI.01982-17⟩
Hepatitis C virus (HCV) infection causes 500,000 deaths annually, in association with end-stage liver diseases. Investigations of the HCV life cycle have widened the knowledge of virology, and here we discovered that two piperazinylbenzenesulfonamide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eede9d22a44a24224a0d9eb270333e63
https://pubmed.ncbi.nlm.nih.gov/29491159
https://pubmed.ncbi.nlm.nih.gov/29491159
Autor:
Christoph Schwärzler, Sylvain Lemeille, Wolf-Henning Boehncke, Hedwig Sutterlüty-Fall, Marylise Fernandez, Rastine Merat
Publikováno v:
Cancer Medicine, Vol. 6, No 7 (2017) pp. 1652-1664
Cancer Medicine
Cancer Medicine
Tumor plasticity and the heterogeneous response of melanoma cells to targeted therapies are major limits for the long‐term efficacy of this line of therapy. Targeting tumor plasticity is theoretically possible through the modulation of the expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39db6c1f4fd5a65b4195357047cb1e95
https://archive-ouverte.unige.ch/unige:106964
https://archive-ouverte.unige.ch/unige:106964
Autor:
Cira Di Gioia, Raffaella Carletti, Silvia Maestroni, Thomas Unger, Giovanna Castoldi, C. Bombardi, Andrea Stella, Gianpaolo Zerbini, U. Muscha Steckelings, Björn Dahlöf
Publikováno v:
Castoldi, G, di Gioia, C R, Bombardi, C, Maestroni, S, Carletti, R, Steckelings, U M, Dahlöf, B, Unger, T, Zerbini, G & Stella, A 2014, ' Prevention of diabetic nephropathy by compound 21, selective agonist of angiotensin type 2 receptors, in Zucker diabetic fatty rats ', American Journal of Physiology: Renal Physiology, vol. 307, no. 10, pp. F1123-F1131 . https://doi.org/10.1152/ajprenal.00247.2014
American Journal of Physiology-Renal Physiology, 307(10), F1123-F1131. American Physiological Society
American Journal of Physiology-Renal Physiology, 307(10), F1123-F1131. American Physiological Society
The aim of this study was to evaluate the effect of compound 21 (C21), a selective AT2 receptor agonist, on diabetic nephropathy and the potential additive effect of C21, when associated with losartan treatment, on the development of albuminuria and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae3004315f2ff815d8cad4b294592e2
https://doi.org/10.1152/ajprenal.00247.2014
https://doi.org/10.1152/ajprenal.00247.2014
Publikováno v:
Pharmacogenetics and Genomics, Vol. 20, No 7 (2010) pp. 455-458
Statins act by reducing hepatic cholesterol synthesis, thus stimulating uptake of serum cholesterol. Statin therapy modulates a number of genes involved in hepatic cholesterol homeostasis. These have rarely been analyzed simultaneously in the same ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f9f174bfc7a9179b777146ce4b9723
https://doi.org/10.1097/fpc.0b013e32833a9328
https://doi.org/10.1097/fpc.0b013e32833a9328
Autor:
Sumitra Ramachandran, Angela A. Dunne, Neil Derek Miller, Laiq Chaudry, Vincent Jaquet, Craig Allan, Aleksandra Filippova, Jean Lim, Ceri H. Davies, Agnes B. Ong, May Thu Ma, Shabina Nasir, Woei Shin Chen, Nicole Y. Ye, Edward R. Browne, Kiew Ching K Lee, Shihua Liao, Douglas G. Johns, Angela Bridges, Yasuji Matsuoka, Chiu Cheong Aw, A. Richard Rutter, Adeline L.W. Chueng, Dizheng Li, Deborah W. Chen, Sri Mulyanidewi, Sarah Duncan, Tamara Seredenina, Gary Pettman, Kazufumi Hirano, Pamela P. Oon
Publikováno v:
Antioxidants & redox signaling, Vol. 23, No 5 (2015) pp. 358-374
Aims: The NADPH oxidase (NOX) family of enzymes catalyzes the formation of reactive oxygen species (ROS). NOX enzymes not only have a key role in a variety of physiological processes but also contribute to oxidative stress in certain disease states.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7ea3e136424a97ddab898f120e2665
https://europepmc.org/articles/PMC4545375/
https://europepmc.org/articles/PMC4545375/