Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Sulev, Koks"'
Publikováno v:
Experimental Biology and Medicine, Vol 249 (2024)
Externí odkaz:
https://doaj.org/article/9e78f040ac9d43298ffac5590c38b011
Autor:
Alexander Fröhlich, Abigail L. Pfaff, Ben Middlehurst, Lauren S. Hughes, Vivien J. Bubb, John P. Quinn, Sulev Koks
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract SINE-VNTR-Alu (SVA) retrotransposons are transposable elements which represent a source of genetic variation. We previously demonstrated that the presence/absence of a human-specific SVA, termed SVA_67, correlated with the progression of Par
Externí odkaz:
https://doaj.org/article/d2f476689c424207a54da2ebbb79a360
Autor:
Ryan L Davis, Deborah Schofield, Carolyn M Sue, Sulev Koks, Christine Klein, George D Mellick, Stephen Tisch, Victor SC Fung, Kishore R Kumar, Laura I Rudaks, Luis M Garcia-Marin, Miguel E Rentería, Hugo Morales-Briceno, Mary-Anne Young, Dennis Yeow, Victor Flores-Ocampo, Wai Y Yau, Kathy HC Wu, Amanda M Willis
Publikováno v:
BMJ Neurology Open, Vol 6, Iss Suppl 1 (2024)
Externí odkaz:
https://doaj.org/article/71cbcbd669834ab0ba75e45e7cc8a6a5
Autor:
Bal Hari Poudel, Sulev Koks
Publikováno v:
Experimental Biology and Medicine, Vol 249 (2024)
Osteosarcoma is a form of bone cancer that predominantly impacts osteoblasts, the cells responsible for creating fresh bone tissue. Typical indications include bone pain, inflammation, sensitivity, mobility constraints, and fractures. Utilising imagi
Externí odkaz:
https://doaj.org/article/f5df69d6dccf4c70862b04f89cf810a8
Autor:
Heather Marriott, Renata Kabiljo, Guy P Hunt, Ahmad Al Khleifat, Ashley Jones, Claire Troakes, Project MinE ALS Sequencing Consortium, TargetALS Sequencing Consortium, Abigail L Pfaff, John P Quinn, Sulev Koks, Richard J Dobson, Patrick Schwab, Ammar Al-Chalabi, Alfredo Iacoangeli
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-20 (2023)
Abstract Amyotrophic lateral sclerosis (ALS) displays considerable clinical and genetic heterogeneity. Machine learning approaches have previously been utilised for patient stratification in ALS as they can disentangle complex disease landscapes. How
Externí odkaz:
https://doaj.org/article/0039ccac3a864796aca41190b1b2c47d
Autor:
Talya Conradie, Jose A. Caparros-Martin, Siobhon Egan, Anthony Kicic, Sulev Koks, Stephen M. Stick, Patricia Agudelo-Romero
Publikováno v:
Viruses, Vol 16, Iss 6, p 953 (2024)
Background: Respiratory viruses significantly impact global morbidity and mortality, causing more disease in humans than any other infectious agent. Beyond pathogens, various viruses and bacteria colonize the respiratory tract without causing disease
Externí odkaz:
https://doaj.org/article/cd92e2ad91b54ac1b2da298bdd492052
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Long interspersed nuclear element-1 (LINE-1/L1) retrotransposons make up 17% of the human genome. They represent one class of transposable elements with the capacity to both mobilize autonomously and in trans via the mobilization of other el
Externí odkaz:
https://doaj.org/article/0d59d7baa0db4388a6876ea34293d174
Autor:
Alexander Fröhlich, Lauren S. Hughes, Ben Middlehurst, Abigail L. Pfaff, Vivien J. Bubb, Sulev Koks, John P. Quinn
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
BackgroundSINE-VNTR-Alu (SVA) retrotransposons are hominid-specific elements which have been shown to play important roles in processes such as chromatin structure remodelling and regulation of gene expression demonstrating that these repetitive elem
Externí odkaz:
https://doaj.org/article/38c1abd247cb4339b4a62507e653761a
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-13 (2022)
Abstract The activation and dysregulation of retrotransposons has been identified in the CNS of individuals with the fatal neurodegenerative disorder Amyotrophic lateral sclerosis (ALS). This includes elements from multiple different families and sub
Externí odkaz:
https://doaj.org/article/505639f94bb9454292343e853c63cee0
Autor:
Jack N. G. Marshall, Alexander Fröhlich, Li Li, Abigail L. Pfaff, Ben Middlehurst, Thomas P. Spargo, Alfredo Iacoangeli, Bing Lang, Ammar Al-Chalabi, Sulev Koks, Vivien J. Bubb, John P. Quinn
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
We describe the characterisation of a variable number tandem repeat (VNTR) domain within intron 1 of the amyotrophic lateral sclerosis (ALS) risk gene CFAP410 (Cilia and flagella associated protein 410) (previously known as C21orf2), providing insigh
Externí odkaz:
https://doaj.org/article/e3eb151ad11e418f88d86ee79eeb04b5