Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Suleiman Al-Sabah"'
Autor:
Bashaier Al‐Zaid, Siby Chacko, Charles Ifeamalume Ezeamuzie, Moritz Bünemann, Cornelius Krasel, Tina Karimian, Peter Lanzerstorfer, Suleiman Al‐Sabah
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 5, Pp n/a-n/a (2022)
Abstract The incretin hormones: glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are important regulators of many aspects of metabolism including insulin secretion. Their receptors (GIPR and GLP‐1R) are
Externí odkaz:
https://doaj.org/article/6e922dfe4b3046d1b2fd74ffc8831fbc
Autor:
Preethi Cherian, Irina Al-Khairi, Mohammad Jamal, Suleiman Al-Sabah, Hamad Ali, Carol Dsouza, Eman Alshawaf, Waleed Al-Ali, Ghanim Al-Khaledi, Fahd Al-Mulla, Mohamed Abu-Farha, Jehad Abubaker
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
The musculoskeletal system consisting of bones and muscles have been recognized as endocrine organs secreting hormones that are involved in regulating metabolic and inflammatory pathways. Obesity and type 2 diabetes (T2D) are associated with several
Externí odkaz:
https://doaj.org/article/801e062f03364aa685dfe737d841047b
Publikováno v:
Pharmaceuticals, Vol 15, Iss 6, p 720 (2022)
Tirzepatide is a dual glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist and a promising therapy for type 2 diabetes mellitus (T2DM). GLP-1 is an incretin hormone with therapeutic potential beyond
Externí odkaz:
https://doaj.org/article/d21596c36ba5426eabbbdb52ec41f792
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The glucose-dependent insulinotropic polypeptide (GIP) and the glucagon-like peptide-1 (GLP-1) receptor are important targets in the treatment of both type 2 diabetes mellitus (T2DM) and obesity. Originally identified for their role in desensitizatio
Externí odkaz:
https://doaj.org/article/ed0c4798cd0147538be21161e531104e
Autor:
Noura Al-Zamel, Suleiman Al-Sabah, Yunus Luqmani, Lobna Adi, Siby Chacko, Tom Dario Schneider, Cornelius Krasel
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9, p 3357 (2020)
The author wishes to make the following correction to this paper [...]
Externí odkaz:
https://doaj.org/article/1d95c5539f984f358c78e29229d357dc
Autor:
Irina AlKhairi, Preethi Cherian, Mohamed Abu-Farha, Ashraf Al Madhoun, Rasheeba Nizam, Motasem Melhem, Mohamed Jamal, Suleiman Al-Sabah, Hamad Ali, Jaakko Tuomilehto, Fahd Al-Mulla, Jehad Abubaker
Publikováno v:
Cells, Vol 8, Iss 10, p 1283 (2019)
Type 2 diabetes (T2D) is a growing pandemic associated with metabolic dysregulation and chronic inflammation. Meteorin-like hormone (METRNL) is an adipomyokine that is linked to T2D. Our objective was to evaluate the changes in METRNL levels in T2D a
Externí odkaz:
https://doaj.org/article/e02f7d4277d448c49a7c0e9b4f9da390
Autor:
Noura Al-Zamel, Suleiman Al-Sabah, Yunus Luqmani, Lobna Adi, Siby Chacko, Tom Dario Schneider, Cornelius Krasel
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 14, p 3532 (2019)
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are important regulators of metabolism, making their receptors (GLP-1R and GIPR) attractive targets in the treatment of type 2 diabetes mellitus (T2DM). GLP-1R ago
Externí odkaz:
https://doaj.org/article/b7085e52277c4add891f3f36522c517c
Autor:
Suleiman Al-Sabah, Munya Al-Fulaij, Ghina Shaaban, Hanadi A Ahmed, Rosalind J Mann, Dan Donnelly, Moritz Bünemann, Cornelius Krasel
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106890 (2014)
BACKGROUND AND OBJECTIVES:Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are important regulators of insulin secretion, and their functional loss is an early characteristic of type 2 diabetes mellitus (T2DM). P
Externí odkaz:
https://doaj.org/article/ea574649047e4aec846a81752c9f956f
Publikováno v:
Molecules, Vol 22, Iss 1, p 22 (2016)
The glucagon-like peptide-1 receptor (GLP-1R) is an important target in the treatment of type 2 diabetes mellitus. The aim of this study was to compare the rate of agonist stimulated desensitization and internalization of GLP-1R. To this end, an N-te
Externí odkaz:
https://doaj.org/article/6363df95815a46a89fcac07896ffed9a
Autor:
Danijela Markovic, Jonathan Holdich, Suleiman Al-Sabah, Rajendra Mistry, Cornelius Krasel, Martyn P Mahaut-Smith, R A John Challiss
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29946 (2012)
Muscarinic acetylcholine receptors (mAChRs) are 7-transmembrane, G protein-coupled receptors that regulate a variety of physiological processes and represent potentially important targets for therapeutic intervention. mAChRs can be stimulated by full
Externí odkaz:
https://doaj.org/article/6f2ae794a82940a8b0a3ea346afcd0b3