Optimization of Tubulysin Antibody-Drug Conjugates: A Case Study in Addressing ADC Metabolism.

Autor: Tumey LN; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Leverett CA; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Vetelino B; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Li F; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Rago B; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Han X; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Loganzo F; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Musto S; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Bai G; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Sukuru SC; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Graziani EI; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Puthenveetil S; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Casavant J; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Ratnayake A; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Marquette K; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Hudson S; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Doppalapudi VR; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Stock J; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Tchistiakova L; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Bessire AJ; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Clark T; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Lucas J; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Hosselet C; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., O'Donnell CJ; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States., Subramanyam C; Pfizer, Inc. , 445 Eastern Point Road, Groton, Connecticut 06379, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2016 Jun 22; Vol. 7 (11), pp. 977-982. Date of Electronic Publication: 2016 Jun 22 (Print Publication: 2016).

New cytotoxic benzosuberene analogs. Synthesis, molecular modeling and biological evaluation.

Autor: Chen Z; Pfizer World Wide Research and Development, World Wide Medicinal Chemistry, Oncology Eastern Point Road, Groton, CT 06340, United States., Maderna A, Sukuru SC, Wagenaar M, O'Donnell CJ, Lam MH, Musto S, Loganzo F

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Dec 15; Vol. 23 (24), pp. 6688-94. Date of Electronic Publication: 2013 Oct 29.

Plate-based diversity selection based on empirical HTS data to enhance the number of hits and their chemical diversity.

Autor: Sukuru SC; Lead Discovery Informatics, Center for Proteomic Chemistry Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA., Jenkins JL, Beckwith RE, Scheiber J, Bender A, Mikhailov D, Davies JW, Glick M

Publikováno v: Journal of biomolecular screening [J Biomol Screen] 2009 Jul; Vol. 14 (6), pp. 690-9. Date of Electronic Publication: 2009 Jun 16.

Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis.

Autor: Scheiber J; Lead Discovery Informatics and Preclinical Safety Profiling, CPC, Novartis Institutes for Biomedical Research, 250 Massachussetts Avenue, Cambridge, Massachusetts 02139, USA. mail@josef-scheiber.de, Chen B, Milik M, Sukuru SC, Bender A, Mikhailov D, Whitebread S, Hamon J, Azzaoui K, Urban L, Glick M, Davies JW, Jenkins JL

Publikováno v: Journal of chemical information and modeling [J Chem Inf Model] 2009 Feb; Vol. 49 (2), pp. 308-17.

The structure of urease activation complexes examined by flexibility analysis, mutagenesis, and small-angle X-ray scattering.

Autor: Quiroz-Valenzuela S; Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI 48824, USA., Sukuru SC, Hausinger RP, Kuhn LA, Heller WT

Publikováno v: Archives of biochemistry and biophysics [Arch Biochem Biophys] 2008 Dec 01; Vol. 480 (1), pp. 51-7. Date of Electronic Publication: 2008 Sep 18.