Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Sukumar, Sakamuri"'
Autor:
Feng Tian, Yi Gu, Sulan Yao, Shiao-Yan Fang, Wayne Yu, Ianina Lopez, Kristine Storey, Robin Marsden, Jessica Kirtley, Sandra Lyn Biroc, Wisam Barkho, Snezana Milutinovic, Amha Gebre Hewet, Nick A. Knudsen, Sukumar Sakamuri, Lillian Skidmore
Amino acid sequence of the antibody used in ARX788. The complementarity determining regions (CDRs) are underlined, and the pAF is depicted as a "U".
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba9be2ac4c8985e17126246813d6898
https://doi.org/10.1158/1535-7163.22521019
https://doi.org/10.1158/1535-7163.22521019
Autor:
Feng Tian, Yi Gu, Sulan Yao, Shiao-Yan Fang, Wayne Yu, Ianina Lopez, Kristine Storey, Robin Marsden, Jessica Kirtley, Sandra Lyn Biroc, Wisam Barkho, Snezana Milutinovic, Amha Gebre Hewet, Nick A. Knudsen, Sukumar Sakamuri, Lillian Skidmore
First-generation antibody–drug conjugates (ADC) are heterogeneous mixtures that have shown clinical benefit, but generally exhibited safety issues and a narrow therapeutic window due, in part, to off-target toxicity caused by ADC instability. ARX78
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cde81fcd8199a2863a821a2439e8526
https://doi.org/10.1158/1535-7163.c.6542869
https://doi.org/10.1158/1535-7163.c.6542869
Autor:
Curt Bradshaw, Sukumar Sakamuri, Bin Liu, Laxman Eltepu, Ryan Preston, Dingguo Liu, Lisa Jo Reboton
Publikováno v:
ChemBioChem. 21:1298-1303
Since the recognition of oligonucleotides as a therapeutic modality, significant work has been devoted to improving therapeutic properties, including nuclease stability. Phosphorothioate (PS) modifications of phosphodiesters are one of the most explo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::874c1135839f1ff87d28c37e128c09e5
https://doi.org/10.1002/cbic.201900631
https://doi.org/10.1002/cbic.201900631
Autor:
Mark P. Foster, Curt W. Bradshaw, Giuseppe Dello Iacono, Laxman Eltepu, Bryan R. Meade, Son Lam, Tom Leedom, Sukumar Sakamuri, Bin Liu, Ayman Kabakibi, Dingguo Liu, Lena Luukkonen
Publikováno v:
ChemBioChem. 21:1304-1308
Oligonucleotides are important therapeutic approaches, as evidenced by recent clinical successes with antisense oligonucleotides (ASOs) and double-stranded short interfering RNAs (siRNAs). Phosphorothioate (PS) modifications are a standard feature in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2081b9e74c8a484b76f632b07556e10a
https://doi.org/10.1002/cbic.201900630
https://doi.org/10.1002/cbic.201900630
Autor:
Sukumar, Sakamuri, Dingguo, Liu, Laxman, Eltepu, Bin, Liu, Lisa Jo, Reboton, Ryan, Preston, Curt W, Bradshaw
Publikováno v:
Chembiochem : a European journal of chemical biology. 21(9)
Since the recognition of oligonucleotides as a therapeutic modality, significant work has been devoted to improving therapeutic properties, including nuclease stability. Phosphorothioate (PS) modifications of phosphodiesters are one of the most explo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::73bf400993334bde9d8edc990be8f636
https://pubmed.ncbi.nlm.nih.gov/31863718
https://pubmed.ncbi.nlm.nih.gov/31863718
Autor:
Yingchun Lu, Vladimir Khazak, Katrin Illgen, Sanjay Menon, Yen-Fang Keng, Silke Schabbert, Lutz Weber, Sukumar Sakamuri, Quin-Zene Chen
Publikováno v:
Letters in Drug Design & Discovery. 3:44-48
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c192e34905daf85cee630029ca40217
https://doi.org/10.2174/157018006775240890
https://doi.org/10.2174/157018006775240890
Autor:
Vladimir Khazak, Katrin Illgen, Quin-Zene Chen, Sanjay Menon, Silke Schabbert, Yingchun Lu, Lutz Weber, Sukumar Sakamuri, Yen-Fang Keng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:3957-3962
A solution phase parallel synthesis approach was undertaken to rapidly explore the structure–activity relationship of an inhibitor of the Ras/Raf protein interaction identified from a small molecule compound library. Evaluation of the MAPK pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8238f7b6d4279e000382047e4f0df983
https://doi.org/10.1016/j.bmcl.2004.05.048
https://doi.org/10.1016/j.bmcl.2004.05.048
Autor:
Sukumar Sakamuri, Alan P. Kozikowski, Kenneth M. Johnson, Srihari R. Tella, Istvan J. Enyedy, Shaomeng Wang, Wahiduz A. Zaman, Tivadar Farkas, Judith L. Flippen-Anderson
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:1123-1136
There is considerable interest in developing dopamine transporter (DAT) inhibitors as potential therapies for the treatment of cocaine abuse. We report herein our pharmacophore-based discovery and molecular modeling-assisted rational design of 2,3-di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc1500e8466e8521e6af35145eb056c
https://doi.org/10.1016/s0968-0896(02)00450-9
https://doi.org/10.1016/s0968-0896(02)00450-9
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:513-517
Abnormal dopamine signaling in brain has been implicated in several conditions such as cocaine abuse, Parkinson's disease and depression. Potent and selective dopamine transporter inhibitors may be useful as pharmacological tools and therapeutic agen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b247ac18a0d147fffbb109a7ba0836
https://doi.org/10.1016/s0960-894x(02)00943-5
https://doi.org/10.1016/s0960-894x(02)00943-5
Autor:
Peter M. Blumberg, Zhi Liang Wei, Pavel A. Petukhov, Alan P. Kozikowski, Clifford George, Sukumar Sakamuri, Nancy E. Lewin
Publikováno v:
Organic Letters. 4:2169-2172
[structures: see text] Both (2S,5R,6R)- and (2S,5R,6S)-6-hydroxy-8-(1-decynyl)benzolactam-V8 were designed and synthesized as PKC modulators. Biological assays reveal the (6R)-ligand to be 20-fold more potent than its (6S)-counterpart in binding to P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b735a3c65b1cb8cde47233620d7bd577
https://doi.org/10.1021/ol026013u
https://doi.org/10.1021/ol026013u