Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Sukumar, Pal"'
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-10 (2024)
Abstract It is recommended that the adjuvant Montanide ISA 720 VG be used at a concentration of 70% v/v. At this concentration, Montanide causes at the site of immunization a local granuloma that can last for several weeks. To determine the safety an
Externí odkaz:
https://doaj.org/article/f1dec0638a1a4b03a3838f277dbdce1a
Autor:
Mariam Mohagheghi, Abisola Abisoye-Ogunniyan, Angela C. Evans, Alexander E. Peterson, Gregory A. Bude, Steven Hoang-Phou, Byron Dillon Vannest, Dominique Hall, Amy Rasley, Dina R. Weilhammer, Nicholas O. Fischer, Wei He, Beverly V. Robinson, Sukumar Pal, Anatoli Slepenkin, Luis de la Maza, Matthew A. Coleman
Publikováno v:
Vaccines, Vol 12, Iss 11, p 1246 (2024)
Background: Vaccine development against Chlamydia, a prevalent sexually transmitted infection (STI), is imperative due to its global public health impact. However, significant challenges arise in the production of effective subunit vaccines based on
Externí odkaz:
https://doaj.org/article/8a73fe6443b6407f917f96d9f4d91582
Autor:
Steven Hoang-Phou, Sukumar Pal, Anatoli Slepenkin, Abisola Abisoye-Ogunniyun, Yuliang Zhang, Sean F. Gilmore, Megan L. Shelby, Feliza A. Bourguet, Mariam V. Mohagheghi, Aleksandr Noy, Amy Rasley, Luis M. de la Maza, Matthew A. Coleman
Publikováno v:
Vaccines, Vol 12, Iss 10, p 1134 (2024)
Background:Chlamydia trachomatis is the most prevalent bacterial sexually transmitted pathogen in humans worldwide. Since chlamydial infection is largely asymptomatic with the potential for serious complications, a preventative vaccine is likely the
Externí odkaz:
https://doaj.org/article/be1c1bfa971e4e1c9f5a37fd0c53218d
Autor:
Kevin B. Weyant, Ayomide Oloyede, Sukumar Pal, Julie Liao, Mariela Rivera-De Jesus, Thapakorn Jaroentomeechai, Tyler D. Moeller, Steven Hoang-Phou, Sean F. Gilmore, Riya Singh, Daniel C. Pan, David Putnam, Christopher Locher, Luis M. de la Maza, Matthew A. Coleman, Matthew P. DeLisa
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Antigen display on outer membrane vesicles (OMVs) can be difficult to control and highly variable. Here, the authors describe a universal approach called AvidVax for linking biotinylated antigens to the exterior of OMVs and enabling rapid vaccine ass
Externí odkaz:
https://doaj.org/article/780bda2f571b451c977ae3d7dffe1457
Autor:
Sukumar Pal, Anatoli Slepenkin, Jiin Felgner, D. Huw Davies, Philip Felgner, Luis M. de la Maza
Publikováno v:
Pathogens, Vol 12, Iss 7, p 863 (2023)
There is an urgent need to produce a vaccine for Chlamydia trachomatis infections. Here, using the Chlamydia muridarum major outer membrane protein (MOMP) as an antigen, four adjuvant combinations IVAX-1 (MPLA+CpG-1018+AddaVax), IVAX-2 (MPLA+CpG-1018
Externí odkaz:
https://doaj.org/article/ce04732fcc6c4827b8a041065e118dca
Autor:
Sukumar Pal, Salvador Fernando Ausar, Delia F. Tifrea, Chunmei Cheng, Scott Gallichan, Violette Sanchez, Luis M. de la Maza, Lucian Visan
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 16, Iss 10, Pp 2537-2547 (2020)
Chlamydia trachomatis is the most common bacterial sexually-transmitted pathogen for which there is no vaccine. We previously demonstrated that the degree of phosphate substitution in an aluminum hydroxide adjuvant in a TLR-4-based C. trachomatis ser
Externí odkaz:
https://doaj.org/article/7997cd92ed784973b63e423efe2f1eef
Autor:
Anatoli Slepenkin, Sukumar Pal, Steven Hoang-Phou, Abisola Abisoye-Ogunniyan, Amy Rasley, Patrik D’haeseleer, Matthew A. Coleman, Luis M. de la Maza
Publikováno v:
Vaccines, Vol 11, Iss 3, p 504 (2023)
Chlamydia trachomatis is the most common bacterial sexually transmitted pathogen. The number of chlamydial infections continuous to increase and there is an urgent need for a safe and efficacious vaccine. To assess the ability of the Chlamydia murida
Externí odkaz:
https://doaj.org/article/4728940a3558479db0f4033a49f92670
Autor:
Abisola Abisoye-Ogunniyan, Isabella M. Carrano, Dina R. Weilhammer, Sean F. Gilmore, Nicholas O. Fischer, Sukumar Pal, Luis M. de la Maza, Matthew A. Coleman, Amy Rasley
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
A worldwide estimate of over one million STIs are acquired daily and there is a desperate need for effective preventive as well as therapeutic measures to curtail this global health burden. Vaccines have been the most effective means for the control
Externí odkaz:
https://doaj.org/article/0fdef6d619294b57b153251ba39f8257
Autor:
Arlo Randall, Andy Teng, Xiaowu Liang, Sukumar Pal, Alice F Tarantal, Joseph Fike, Peter A Barry, Luis M de la Maza
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250317 (2021)
To identify immunodominant antigens that elicit a humoral immune response following a primary and a secondary genital infection, rhesus monkeys were inoculated cervically with Chlamydia trachomatis serovar D. Serum samples were collected and probed w
Externí odkaz:
https://doaj.org/article/69d6a9945e3245d8ad8f0cd058066446
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0230718 (2020)
Chlamydia trachomatis is the most common bacterial sexually-transmitted infection and the major cause of preventable blindness worldwide. The asymptomatic nature of many infections along with uncontrolled inflammation leads to irreversible damage in
Externí odkaz:
https://doaj.org/article/3cc8f122d137488e8d099265922b7f97