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Genetic regulation of fetal hemoglobin across global populations.

Autor: Cato LD; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Li R; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Lu HY; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Yu F; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Wissman M; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Mkumbe BS; Sickle Cell Program, Department of Hematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.; Department of Biochemistry, Muhimbili University of Health and Allied Science, Dar es Salaam, Tanzania.; Department of Artificial Intelligence and Innovative Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan., Ekwattanakit S; Siriraj Thalassemia Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Deelen P; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Oncode Institute, Amsterdam, the Netherlands., Mwita L; Department of Pharmaceutical Microbiology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania., Sangeda R; Sickle Cell Program, Department of Hematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.; Department of Pharmaceutical Microbiology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania., Suksangpleng T; Siriraj Thalassemia Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Riolueang S; Siriraj Thalassemia Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Bronson PG; R&D Translational Biology, Biogen, Cambridge, Massachusetts, USA., Paul DS; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK., Kawabata E; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Astle WJ; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.; NHS Blood and Transplant, Cambridge, UK., Aguet F; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Ardlie K; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., de Lapuente Portilla AL; Lund Stem Cell Center, Lund University, 221 84 Lund, Sweden.; Department of Laboratory Medicine, Lund University, 221 84 Lund, Sweden., Kang G; St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Zhang Y; Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Nouraie SM; Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Gordeuk VR; Division of Hematology and Oncology, Department of Medicine, Comprehensive Sickle Cell Center, University of Illinois at Chicago, Chicago, Illinois, USA., Gladwin MT; Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA., Garrett ME; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Ashley-Koch A; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Telen MJ; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Custer B; Vitalant Research Institute, San Francisco, California, USA.; Department of Laboratory Medicine, UCSF, San Francisco, California, USA., Kelly S; Vitalant Research Institute, San Francisco, California, USA.; Division of Pediatric Hematology, UCSF Benioff Children's Hospital, Oakland, California, USA., Dinardo CL; Fundacao Pro-Sangue Hemocentro de Sao Paulo, Sao Paulo, Brazil.; Institute of Tropical Medicine, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil., Sabino EC; Institute of Tropical Medicine, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil., Loureiro P; Fundacao Hemope, Recife, Pernambuco, Brazil., Carneiro-Proietti AB; Fundacao Hemominas, Belo Horizonte, Brazil., Maximo C; Fundacao Hemorio, Rio de Janeiro, Brazil., Méndez A; Institute of Laboratory Medicine, Cantonal Hospital Aarau, 5000 Aarau, Switzerland., Hammerer-Lercher A; Institute of Laboratory Medicine, Cantonal Hospital Aarau, 5000 Aarau, Switzerland., Sheehan VA; Aflac Cancer & Blood Disorders Center, Children's Healthcare of Atlanta & Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA., Weiss MJ; St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Franke L; Oncode Institute, Amsterdam, the Netherlands.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Nilsson B; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Lund Stem Cell Center, Lund University, 221 84 Lund, Sweden.; Department of Laboratory Medicine, Lund University, 221 84 Lund, Sweden., Butterworth AS; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Viprakasit V; Siriraj Thalassemia Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.; Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Nkya S; Sickle Cell Program, Department of Hematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.; Department of Biochemistry, Muhimbili University of Health and Allied Science, Dar es Salaam, Tanzania.; Tanzania Human Genetics Organisation, Tanzania., Sankaran VG; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.; Department of Biochemistry, Muhimbili University of Health and Allied Science.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Mar 28. Date of Electronic Publication: 2023 Mar 28.