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Androgen deprivation induces neuroendocrine phenotypes in prostate cancer cells through CREB1/EZH2-mediated downregulation of REST

Autor: Dayong Zheng, Yan Zhang, Sukjin Yang, Ning Su, Michael Bakhoum, Guoliang Zhang, Samira Naderinezhad, Zhengmei Mao, Zheng Wang, Ting Zhou, Wenliang Li

Publikováno v: Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)

Abstract Although effective initially, prolonged androgen deprivation therapy (ADT) promotes neuroendocrine differentiation (NED) and prostate cancer (PCa) progression. It is incompletely understood how ADT transcriptionally induces NE genes in PCa c

Externí odkaz: https://doaj.org/article/90b69f9b55bf4bdc9486b4db44b5ad47

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Abstract P6-11-01: Scaffold attachment factor B1 modulates cholesterol pathways in triple-negative breast cancer

Autor: Meron Ghidey, Divya Murthy, Sukjin Yang, Songyeon Ahn, Jun Hyoung Park, Benny Kaipparettu

Publikováno v: Cancer Research. 83:P6-11

Historically known as a tumor suppressor by estrogen receptor (ER) co-repression in breast cancer (BC), the matrix binding protein Scaffold Attachment Factor B1 (SAFB) binds scaffold or matrix attachment region DNA elements (S/MAR DNA) in eukaryotic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8383a4c99a7f571857bd09f25747a1b
https://doi.org/10.1158/1538-7445.sabcs22-p6-11-01

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Abstract P6-11-11: Breast cancer stem cell marker, CD24 regulates metabolic reprogramming in triple negative breast cancer

Autor: Divya Murthy, Debasmita Dutta, Sukjin Yang, Junhyoung Park, Benny Kaipparettu

Publikováno v: Cancer Research. 83:P6-11

Breast cancer stem cell (BCSC) is a subset of cancer cells that can dictate the tumor initiation, metastatic progression, and therapeutic resistance in BC. The eradication of this unusual population is emerging as a new paradigm in cancer treatment.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a2ac1b43fbad92eee9a06204829257b
https://doi.org/10.1158/1538-7445.sabcs22-p6-11-11

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Abstract P6-11-02: Mitochondria-Nuclear Crosstalk Regulates the WNT Pathway in Triple-Negative Breast Cancer

Autor: Sukjin Yang, Jun Hyoung Park, Suna Kim, Meron Ghidey, Benny Kaipparettu

Publikováno v: Cancer Research. 83:P6-11

Compared to hormone receptor (HR) positive breast cancer (BC), basal or triple-negative BC (TNBC) suffers a poor prognosis caused by a limited understanding of its driver signaling pathways. We used the transmitochondrial cybrid approach to understan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c94144fe469a04bc01784ee30de0efcb
https://doi.org/10.1158/1538-7445.sabcs22-p6-11-02

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Abstract 294: Tumor concentration of metformin is a determinant factor of its regulation of fatty acid β-oxidation and c-Src pathway in triple-negative breast cancer

Autor: Junhyoung Park, Kwang Hwa Jung, Dongya Jia, Sukjin Yang, Kuldeep S. Attri, Songyeon Ahn, Divya Murthy, Meron Ghidey, Somik Chatterjee, Diego A. Pedroza, Abha Tiwari, Suna Kim, Chad C. Creighton, Nagireddy Putluri, Jeffrey M. Rosen, José N. Onuchic, Andrei Goga, Benny A. Kaipparettu

Publikováno v: Cancer Research. 83:294-294

Biguanides such as metformin are one of the most widely administered anti-diabetic drugs. Biguanides can suppress OXPHOS by inhibiting the complex-I activity of the mitochondrial electron transport chain (ETC). Though metformin recently generated lot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7bda6b7e873d60ad146423d88c53ae86
https://doi.org/10.1158/1538-7445.am2023-294

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Towards decoding the coupled decision-making of metabolism and epithelial-to-mesenchymal transition in cancer

Autor: Jun Hyoung Park, Herbert Levine, Shubham Tripathi, Youyuan Deng, Kwang Hwa Jung, Dongya Jia, Benny Abraham Kaipparettu, José N. Onuchic, Harsimran Kaur, Mohit Kumar Jolly, Sukjin Yang, Madeline Galbraith

Publikováno v: Br J Cancer

Cancer cells have the plasticity to adjust their metabolic phenotypes for survival and metastasis. A developmental programme known as epithelial-to-mesenchymal transition (EMT) plays a critical role during metastasis, promoting the loss of polarity a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ab999f5c95fd51666dd29ebf706b15
https://doi.org/10.1038/s41416-021-01385-y

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Abstract 3986: Combination of tamoxifen and doxorubicin targets estrogen receptor beta-mutant p53-p73 axis: A novel therapeutic strategy for triple negative breast cancer

Autor: Gokul M. Das, Chetan C. Oturkar, Christina Adams, Jung H. Park, Melissa Dolan, Michalis Mastri, Manasori Oshi, Yoshihisa Tokumaru, Utpal K. Mukhopadhyay, Kalyani Abha, Kwang H. Jung, Sukjin Yang, Suna Kim, John Ebos, Kazuaki Takabe, Benny A. Kaipparettu

Publikováno v: Cancer Research. 82:3986-3986

Triple-negative breast cancer (TNBC) is an aggressive subtype without any effective targeted therapies and rapidly become resistant to generic chemotherapy. Therefore, there is an urgent need to develop new therapeutic strategies. Estrogen receptor b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58df593e1b0290668b72c0e2f4b755fa
https://doi.org/10.1158/1538-7445.am2022-3986

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Abstract P5-05-06: Metformin concentration is a deciding factor of its pro- or anti-tumor function in triple negative breast cancer

Autor: Jun Hyoung Park, Dongya Jia, Sukjin Yang, Kwang Hwa Jung, Abha Tiwari, Debasmita Dutta, Meron Ghidey, Nagireddy Putluri, Cristian Coarfa, Chad Creighton, José N. Onuchic, Benny A Kaipparettu

Publikováno v: Cancer Research. 82:P5-05

We have previously reported that triple negative (TN) breast cancer (BC), an aggressive subtype of BC, has high dependency for mitochondrial fatty acid oxidation (FAO). We have also reported that FAO activates c-Src, one of the frequently upregulated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23944bf403513b5455ad8a8a3128d413
https://doi.org/10.1158/1538-7445.sabcs21-p5-05-06

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High-fructose corn syrup enhances intestinal tumor growth in mice

Publikováno v: Science. 363:1345-1349

A sweetener's not-so-sweet effects Obesity increases an individual's risk of developing many types of cancer, including colorectal cancer. One of the factors driving the rise in obesity rates is thought to be the use of high-fructose corn syrup (HFCS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04858bd1cbebe122c2a3091a77cbd32b
https://doi.org/10.1126/science.aat8515

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LAD1 expression is associated with the metastatic potential of colorectal cancer cells

Autor: Eun-Jeong Jeong, Mijin Park, Seong-Min Park, Kyu Sang Song, Young Il Yeom, Jung-Ae Kim, Byul Moon, Sukjin Yang, Jang-Seong Kim, Sang-Hyun Lee

Publikováno v: BMC Cancer, Vol 20, Iss 1, Pp 1-12 (2020)
BMC Cancer

Background Anchoring filament protein ladinin-1 (LAD1) was related to the aggressive progression of breast, lung, laryngeal and thyroid cancers. However, the association of LAD1 with colorectal cancer remained unknown. Here, to determine the relation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b63b2dda2c24205e9aaca3da97632a
https://doi.org/10.1186/s12885-020-07660-0

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