Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Sukhvir P. Mahal"'
Autor:
Sukhvir Paul Mahal, Joseph Jablonski, Irena Suponitsky-Kroyter, Anja Maria Oelschlegel, Maria Eugenia Herva, Michael Oldstone, Charles Weissmann
Publikováno v:
PLoS Pathogens, Vol 8, Iss 6, p e1002746 (2012)
PrP(C), a host protein which in prion-infected animals is converted to PrP(Sc), is linked to the cell membrane by a GPI anchor. Mice expressing PrP(C) without GPI anchor (tgGPI⁻ mice), are susceptible to prion infection but accumulate anchorless Pr
Externí odkaz:
https://doaj.org/article/f3576846260f4508b2f70776e10df08b
Autor:
Yervand Eduard Karapetyan, Paula Saá, Sukhvir Paul Mahal, Gian Franco Sferrazza, Alexandra Sherman, Nicole Salès, Charles Weissmann, Corinne Ida Lasmézas
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5730 (2009)
Prion strain identification has been hitherto achieved using time-consuming incubation time determinations in one or more mouse lines and elaborate neuropathological assessment. In the present work, we make a detailed study of the properties of PrP-o
Externí odkaz:
https://doaj.org/article/e8cef4a3c83e4f7aacf804fb91c9b123
Autor:
Simon Mead, John Collinge, Sukhvir P. Mahal, Elizabeth M. C. Fisher, Martin Farrall, Tracy Campbell, John Beck
Human prion diseases have inherited, sporadic, and acquired etiologies. The appearance of the novel acquired prion disease, variant Creutzfeldt-Jakob disease (vCJD), and the demonstration that it is caused by the same prion strain as that causing bov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f952d823c49125b354a3e50f6d113d59
https://ora.ox.ac.uk/objects/uuid:3bbdd3ef-7a49-4afb-8294-dbee3e3311ed
https://ora.ox.ac.uk/objects/uuid:3bbdd3ef-7a49-4afb-8294-dbee3e3311ed
Publikováno v:
EMBO reports. 12:1109-1117
Prions consist mainly, if not entirely, of PrP(Sc), an aggregated conformer of the host protein PrP(C). Prions come in different strains, all based on the same PrP(C) sequence, but differing in their conformations. The efficiency of prion transmissio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b878c754b01db0222c04f888c58fbade
https://doi.org/10.1038/embor.2011.192
https://doi.org/10.1038/embor.2011.192
Publikováno v:
EMBO Reports
Mutability of prions Prions are shown to be mutable, and prion substrains have distinct mutation capacity. However, even clones that seem virtually immutable change when the environmental conditions are altered. Mutability is thus a prion substrain-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbcbca42f7787a764498efc29b3ec0ac
http://europepmc.org/articles/PMC3245691
http://europepmc.org/articles/PMC3245691
Autor:
Sukhvir P. Mahal, Charles Weissmann, Emery Smith, Cheryl A. Demczyk, Christian Julius, Christopher A. Baker
Publikováno v:
Proceedings of the National Academy of Sciences. 104:20908-20913
Prions are thought to consist mainly or entirely of misfolded PrP, a constitutively expressed host protein. Prions associated with the same PrP sequence may occur in the form of different strains; the strain phenotype is believed to be encoded by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b4689588fd697e5b4b9a347812747eb
https://doi.org/10.1073/pnas.0710054104
https://doi.org/10.1073/pnas.0710054104
Publikováno v:
Neurobiology of Disease, Vol 10, Iss 1, Pp 1-7 (2002)
The prion protein is central to the pathogenesis of prion diseases, although its exact function remains unclear. Although transgenic mice have been widely utilised in prion research, their PrP expression patterns have not been characterised in detail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a045ec29c8f4e617148d64ffcb9ec1
https://doi.org/10.1006/nbdi.2002.0486
https://doi.org/10.1006/nbdi.2002.0486
Autor:
Robert A. Somerville, Pedro Piccardo, Jean Manson, Deborah Brown, Abigail B. Diack, Sukhvir P. Mahal, Charles Weissmann, Enrico Cancellotti
Publikováno v:
The EMBO journal. 32(5)
Central to understanding the nature TSE agents (or prions) is how their genetic information is distinguished from the host. Are TSEs truly infectious diseases with host-independent genomes, or are they aberrations of a host component derived from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f254ad22af54f8033196a1aacc37dd17
https://pubmed.ncbi.nlm.nih.gov/23787696
https://pubmed.ncbi.nlm.nih.gov/23787696
Autor:
Maria Eugenia Herva, Michael B. A. Oldstone, Charles Weissmann, Anja M. Oelschlegel, Joseph A. Jablonski, Sukhvir P. Mahal, Irena Suponitsky-Kroyter
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 8, Iss 6, p e1002746 (2012)
PLoS Pathogens, Vol 8, Iss 6, p e1002746 (2012)
PrPC, a host protein which in prion-infected animals is converted to PrPSc, is linked to the cell membrane by a GPI anchor. Mice expressing PrPC without GPI anchor (tgGPI- mice), are susceptible to prion infection but accumulate anchorless PrPSc extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1cd8468fff49aec322bb5d829d4ab03
https://pubmed.ncbi.nlm.nih.gov/22685404
https://pubmed.ncbi.nlm.nih.gov/22685404
Autor:
Maria Eugenia Herva, Jiali Li, Charles Weissmann, Sukhvir P. Mahal, Cheryl A. Demczyk, Emery Smith, Shawn Browning, Christopher A. Baker
Neuroblastoma-derived N2a-PK1 cells, fibroblastic LD9 cells, and CNS-derived CAD5 cells can be infected efficiently and persistently by various prion strains, as measured by the standard scrapie cell assay. Swainsonine, an inhibitor of Golgi α-manno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757dd7f48ade4b270cb49e969587c153
https://europepmc.org/articles/PMC3220511/
https://europepmc.org/articles/PMC3220511/