Výsledky vyhledávání - "Sukhmani Bedi"

Akademický článek

Self-amplifying mRNA bicistronic influenza vaccines raise cross-reactive immune responses in mice and prevent infection in ferrets

Autor: Cheng Chang, Nedzad Music, Michael Cheung, Evan Rossignol, Sukhmani Bedi, Harsh Patel, Mohammad Safari, Changkeun Lee, Gillis R. Otten, Ethan C. Settembre, Giuseppe Palladino, Yingxia Wen

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 195-205 (2022)

Vaccines are the primary intervention against influenza. Currently licensed inactivated vaccines focus immunity on viral hemagglutinin (HA). Self-amplifying mRNA (sa-mRNA) vaccines offer an opportunity to generate immunity to multiple viral proteins,

Externí odkaz: https://doaj.org/article/912ad34f33834057b76e58f148316bfd

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Akademický článek

Self-amplifying mRNA bicistronic influenza vaccines raise cross-reactive immune responses in mice and prevent infection in ferrets

Autor: Cheng Chang, Nedzad Music, Michael Cheung, Evan Rossignol, Sukhmani Bedi, Harsh Patel, Mohammad Safari, Changkeun Lee, Gillis R. Otten, Ethan C. Settembre, Giuseppe Palladino, Yingxia Wen

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 11- (2023)

Externí odkaz: https://doaj.org/article/f42ddb960d474101a8756cdd0d6e57e5

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Akademický článek

Host Retromer Protein Sorting Nexin 2 Interacts with Human Respiratory Syncytial Virus Structural Proteins and is Required for Efficient Viral Production

Autor: Ricardo S. Cardoso, Lucas Alves Tavares, Bruna Lais S. Jesus, Miria F. Criado, Andreia Nogueira de Carvalho, Juliano de Paula Souza, Sukhmani Bedi, Marcos Michel de Souza, Maria Lucia Silva, Guilherme Pauperio Lanfredi, Brenda Cristina Vitti, Orlando Bonito Scudero, Vitor Marcel Faça, Akira Ono, Armando M. Ventura, Luis Lamberti P. daSilva, Eurico Arruda

Publikováno v: mBio, Vol 11, Iss 5 (2020)

ABSTRACT Human respiratory syncytial virus (HRSV) envelope glycoproteins traffic to assembly sites through the secretory pathway, while nonglycosylated proteins M and N are present in HRSV inclusion bodies but must reach the plasma membrane, where HR

Externí odkaz: https://doaj.org/article/677e053382274242a051b92585a6cb7e

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Akademický článek

A Defect in Influenza A Virus Particle Assembly Specific to Primary Human Macrophages

Autor: Sukhmani Bedi, Takeshi Noda, Yoshihiro Kawaoka, Akira Ono

Publikováno v: mBio, Vol 9, Iss 5 (2018)

ABSTRACT Influenza A virus (IAV) propagates efficiently in epithelial cells, its primary target in the respiratory tract. In contrast, productive infection of most IAV strains is either blocked or highly inefficient in macrophages. The exact nature o

Externí odkaz: https://doaj.org/article/d92cd2ca561a481d92ba0fcb467c797d

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Akademický článek

Friend or Foe: The Role of the Cytoskeleton in Influenza A Virus Assembly

Autor: Sukhmani Bedi, Akira Ono

Publikováno v: Viruses, Vol 11, Iss 1, p 46 (2019)

Influenza A Virus (IAV) is a respiratory virus that causes seasonal outbreaks annually and pandemics occasionally. The main targets of the virus are epithelial cells in the respiratory tract. Like many other viruses, IAV employs the host cell’s mac

Externí odkaz: https://doaj.org/article/ed1d72246fd44025bfb33b6e74bbb6ac

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A Glu-Glu-Tyr Sequence in the Cytoplasmic Tail of the M2 Protein Renders Influenza A Virus Susceptible to Restriction of the Hemagglutinin-M2 Association in Primary Human Macrophages

Autor: Sukhmani Bedi, Rajat Mudgal, Amanda Haag, Akira Ono

Publikováno v: J Virol

Influenza A virus (IAV) assembly at the plasma membrane is orchestrated by at least five viral components, including hemagglutinin (HA), neuraminidase (NA), matrix (M1), the ion channel M2, and viral ribonucleoprotein (vRNP) complexes, although parti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6b441af7203a6b7ce3cb76dc60621a
https://doi.org/10.1128/jvi.00716-22

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Host Retromer Protein Sorting Nexin 2 Interacts with Human Respiratory Syncytial Virus Structural Proteins and is Required for Efficient Viral Production

Autor: Maria Lucia Caetano Pinto da Silva, Vitor M. Faça, Lucas Alves Tavares, Juliano de Paula Souza, Orlando Bonito Scudero, Brenda Cristina Vitti, Luis L. P. daSilva, Sukhmani Bedi, Armando Morais Ventura, Miria Ferreira Criado, Bruna Lais Santos de Jesus, Akira Ono, Andreia N. de Carvalho, Marcos Michel de Souza, Ricardo S. Cardoso, Eurico Arruda, Guilherme Pauperio Lanfredi

Publikováno v: mBio
mBio, Vol 11, Iss 5 (2020)

The present study contributes new knowledge to understand HRSV assembly by providing evidence that nonglycosylated structural proteins M and N interact with elements of the secretory pathway, shedding light on their intracellular traffic. To the best

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e981b249093c475841ea4fc82d8e67d3
https://doi.org/10.1128/mbio.01869-20

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A Glu-Glu-Tyr sequence in the cytoplasmic tail of the M2 protein renders IAV susceptible to restriction of HA-M2 association in primary human macrophages

Autor: Amanda Haag, Sukhmani Bedi, Akira Ono

Influenza A virus (IAV) assembly at the plasma membrane is orchestrated by at least five viral components including hemagglutinin (HA), neuraminidase (NA), matrix (M1), the ion channel M2, and viral ribonucleoprotein (vRNP) complexes although particl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::012be6ed33e79e5af1713f1fa2934938
https://doi.org/10.1101/2020.07.01.183186

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Molecular Determinants Directing HIV-1 Gag Assembly to Virus-Containing Compartments in Primary Macrophages

Autor: Vineela Chukkapalli, Akira Ono, Jingga Inlora, Sukhmani Bedi

The subcellular sites of HIV-1 assembly, determined by the localization of the structural protein Gag, vary in a cell-type-dependent manner. In T cells and transformed cell lines used as model systems, HIV-1 assembles at the plasma membrane (PM). The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6345b2c35fe4a40986da23d3aa8679b4
https://europepmc.org/articles/PMC5021390/

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The C-Terminal Acidic Region of Calreticulin Mediates Phosphatidylserine Binding and Apoptotic Cell Phagocytosis

Autor: David Anh Huy Huynh, Sanjeeva J. Wijeyesakere, Sukhmani Bedi, Malini Raghavan

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 196(9)

Calreticulin is a calcium-binding chaperone that is normally localized in the endoplasmic reticulum. Calreticulin is detectable on the surface of apoptotic cells under some apoptosis-inducing conditions, where it promotes the phagocytosis and immunog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6efb0c55d0a37120129458befe74a8e1
https://pubmed.ncbi.nlm.nih.gov/27036911

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