Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Sukhen C Ghosh"'
Autor:
Vahid Khalaj, Solmaz AghaAmiri, Sukhen C Ghosh, Servando Hernandez Vargas, Majid Momeny, Ali Azhdarinia
Publikováno v:
BioTechniques, Vol 76, Iss 7, Pp 343-351 (2024)
O6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme that is overexpressed in certain tumors and is associated with resistance to the DNA alkylating agent temozolomide. MGMT inhibitors show potential in combating temozolomide resistan
Externí odkaz:
https://doaj.org/article/837c587770404699beb6449c35f43eb0
Autor:
Servando Hernandez Vargas, Christie Lin, Hop S. Tran Cao, Naruhiko Ikoma, Solmaz AghaAmiri, Sukhen C. Ghosh, Adam J. Uselmann, Ali Azhdarinia
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Cancer surgery remains the primary treatment option for most solid tumors and can be curative if all malignant cells are removed. Surgeons have historically relied on visual and tactile cues to maximize tumor resection, but clinical data suggest that
Externí odkaz:
https://doaj.org/article/cc321ad8697b4e0f828b5c3e789830be
Autor:
Solmaz AghaAmiri, Jo Simien, Alastair M. Thompson, Julie Voss, Sukhen C. Ghosh, Servando Hernandez Vargas, Sarah Kim, Ali Azhdarinia, Hop S. Tran Cao
Publikováno v:
Molecular Imaging, Vol 2021 (2021)
Background. Although therapeutic advances have led to enhanced survival in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer, detection of residual disease remains challenging. Here, we examine two approved anti-HER
Externí odkaz:
https://doaj.org/article/74b901709eb247d592dd2599a37eb432
Autor:
Servando Hernandez Vargas, Solmaz AghaAmiri, Sukhen C. Ghosh, Michael P. Luciano, Luis C. Borbon, Po Hien Ear, James R. Howe, Jennifer M. Bailey-Lundberg, Gregory D. Simonek, Daniel M. Halperin, Hop S. Tran Cao, Naruhiko Ikoma, Martin J. Schnermann, Ali Azhdarinia
Publikováno v:
Molecular Pharmaceutics. 19:4241-4253
Dye design can influence the ability of fluorescently labeled imaging agents to generate tumor contrast and has become an area of significant interest in the field of fluorescence-guided surgery (FGS). Here, we show that the charge-balanced near-infr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d22656ecf3f0c0e6070422ae7a2dff
https://doi.org/10.1021/acs.molpharmaceut.2c00583
https://doi.org/10.1021/acs.molpharmaceut.2c00583
Autor:
Kendra S. Carmon, Qingyun Liu, Zhiqiang An, Wei Xiong, Sukhen C. Ghosh, Ali Azhdarinia, Xing Gong
Gastrointestinal cancer is one of the leading causes of cancer-related mortality in men and women worldwide. The adult stem cell marker LGR5 (leucine-rich repeat-containing, G protein–coupled receptor 5) is highly expressed in a significant fractio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c59b37964449566d895fc6083bb08644
https://doi.org/10.1158/1535-7163.c.6538692.v1
https://doi.org/10.1158/1535-7163.c.6538692.v1
Autor:
Kendra S. Carmon, Qingyun Liu, Zhiqiang An, Wei Xiong, Sukhen C. Ghosh, Ali Azhdarinia, Xing Gong
Supplementary Fig. S1- Coomassie gel of anti-LGR5 mAb and anti-LGR5 ADCs. Supplementary Fig. S2- Confocal image of HEK293T cells with stable over-expression of hLGR4. Supplementary Fig. S3- Anti-LGR5 ADC binding assay and cytotoxicity of free MMAE. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245c7be1e39ce74dbb6973f53c6f4d2b
https://doi.org/10.1158/1535-7163.22507449.v1
https://doi.org/10.1158/1535-7163.22507449.v1
Autor:
Anil K. Sood, Jim Klostergaard, Wei Hu, Jie Huang, Yu Kang, Nicholas B Jennings, Duangmani Thanapprapasr, Behrouz Zand, Chad V. Pecot, Masato Nishimura, Chunhua Lu, Alejandro Lopez-Araujo, Edmond J. Auzenne, De Yue Shen, Justin Bottsford-Miller, Rebecca L. Stone, Hee Dong Han, Sukhen C. Ghosh, Sun Joo Lee
Purpose: Most primary human ovarian tumors and peritoneal implants, as well as tumor vascular endothelial cells, express the CD44 family of cell surface proteoglycans, the natural ligand for which is hyaluronic acid. Metronomic dosing, the frequent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3315af3e1a1442747c895e08633971
https://doi.org/10.1158/1078-0432.c.6520709
https://doi.org/10.1158/1078-0432.c.6520709
Autor:
Mikhail G. Kolonin, Ali Azhdarinia, Sukhen C. Ghosh, Solmaz AghaAmiri, Alexes C. Daquinag, Shraddha Subramanian
Supplementary Figures 1-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce821c02795b2e0433234fbb8a707290
https://doi.org/10.1158/0008-5472.22429921.v1
https://doi.org/10.1158/0008-5472.22429921.v1
Autor:
Ali Azhdarinia, William E. Fisher, Sadhna Dhingra, Thomas Reiner, Jo Simien, Hop S. Tran Cao, Sukhen C. Ghosh, Julie Voss, Susanne Kossatz, Servando Hernandez Vargas
Purpose:Clinically available intraoperative imaging tools to assist surgeons in identifying occult lesions are limited and partially responsible for the high rate of disease recurrence in patients with neuroendocrine tumors (NET). Using the establish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67e8b97ecb6756723c38a253b85590a
https://doi.org/10.1158/1078-0432.c.6527807.v1
https://doi.org/10.1158/1078-0432.c.6527807.v1
Autor:
Anil K. Sood, Jim Klostergaard, Wei Hu, Jie Huang, Yu Kang, Nicholas B Jennings, Duangmani Thanapprapasr, Behrouz Zand, Chad V. Pecot, Masato Nishimura, Chunhua Lu, Alejandro Lopez-Araujo, Edmond J. Auzenne, De Yue Shen, Justin Bottsford-Miller, Rebecca L. Stone, Hee Dong Han, Sukhen C. Ghosh, Sun Joo Lee
PDF file, 366KB, Effects of MET and MTD HA-TXL treatment in the HeyA8-MDR model on biological endpoints.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26dc0d2cb5bbcf2e0e1df87b46d58d98
https://doi.org/10.1158/1078-0432.22446278
https://doi.org/10.1158/1078-0432.22446278