Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Sukhdev Manku"'
Autor:
Jeffrey M. Besterman, Amal Wahhab, Alain Ajamian, Martin Allan, Sylvain Lefebvre, Alina Nicolescu, Robert Deziel, Eric Therrien, Jacques Rodrigue, Sukhdev Manku, Jubrail Rahil, Andrea J. Petschner, Zuomei Li, Marielle Fournel, James Wang, Tim Guo, Natalie Nguyen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1866-1870
We have recently reported on a novel class of histone deacetylase (HDAC) inhibitors bearing a sulfamide group as the zinc-binding unit. Herein, we report on the synthesis of sulfamide based inhibitors designed around a lysine scaffold and their struc
Autor:
Sylvain Lefebvre, Silvana Leit, Alina Nicolescu, Marielle Fournel, Anthony Panetta, Jeffrey M. Besterman, Jubrail Rahil, Amal Wahhab, Anne-Marie Lemieux, Sukhdev Manku, Christiane R. Maroun, Yves Andre Chantigny, Theresa P. Yan, Robert Deziel, Zuomei Li, David Smil
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:688-692
In an effort to identify HDAC isoform selective inhibitors, we designed and synthesized novel, chiral 3,4-dihydroquinoxalin-2(1H)-one and piperazine-2,5-dione aryl hydroxamates showing selectivity (up to 40-fold) for human HDAC6 over other class I/II
Autor:
Dennis P. Curran, Sukhdev Manku
Publikováno v:
The Journal of Organic Chemistry. 70:4470-4473
Simple HPLC experiments were used to identify a redundant tagging scheme wherein six different amino acids were tagged with only four fluorous tags. The tagged amino acids were converted to regiosiomeric mixtures of tricyclic hydantoins. Despite the
Autor:
Sukhdev Manku, Dennis P. Curran
Publikováno v:
Journal of Combinatorial Chemistry. 7:63-68
Fluorous mixture synthesis was used to prepare a library of 4-alkylidene cyclopentenones starting from a mixture of four alpha-amino acid derivatives tagged with different fluorous benzyl carbamates ((F)CBz) of varying fluorine content. The amino aci
Publikováno v:
Journal of Combinatorial Chemistry. 5:379-391
Natural polyamines are ubiquitous biomolecules present in all living cells. These cationic compounds play essential roles in both cell growth and differentiation and are known to interact in complex ways with polyanionic biomolecules. Consequently, t
Publikováno v:
Journal of Combinatorial Chemistry. 3:125-150
Publikováno v:
The Journal of Organic Chemistry. 66:874-885
A mild oxidative workup protocol using iodine in an acetic acid-acetate buffer solution is described for the cleavage of borane-amine adducts arising from the borane-promoted reduction of polyamides supported onto practical trityl-based resins. Chira
Publikováno v:
ChemInform. 28
A trimeric beta-lactosyl cluster based on 2-nitro-2-(hydroxymethyl)propane-1,3-diol was prepared using the trichloroacetimidate method. Kinetic studies showed that this cluster was an effective acceptor for rat-liver alpha-(2-->3)-sialyltransferase.
Publikováno v:
Organic Letters. 2:1581-1583
[structure--se text] Polyamine toxins HO-416b (1) and PhTX-433 (2) isolated from the venom of insects are important lead compounds in neuropharmacology. Their total synthesis has been achieved on a trityl derivatized resin in good yield and purity us
Autor:
Jeffrey M. Besterman, Amal Wahhab, Martin Allan, Anne-Christine Goulet, Guillaume Larouche, Marie-France Robert, Eric Therrien, Natalie Nguyen, Sylvia Styhler, Hannah Nguyen, Sukhdev Manku
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(23)
We have identified the N(1)-benzyl-N(2)-methylethane-1,2-diamine unit as a substitute for the (S)-alanine benzylamide moiety for the design of co-activator associated arginine methyltransferase 1 (CARM1) inhibitors. The potency of these inhibitors is