Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sukanya Iyer"'
Autor:
Sukanya Iyer, Marwa Ismail, Benita Tamrazi, Ralph Salloum, Peter de Blank, Ashley Margol, Ramon Correa, Jonathan Chen, Kaustav Bera, Volodymyr Statsevych, Mai-Lan Ho, Pranjal Vaidya, Ruchika Verma, Debra Hawes, Alexander Judkins, Pingfu Fu, Anant Madabhushi, Pallavi Tiwari
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IntroductionMedulloblastoma (MB) is a malignant, heterogenous brain tumor. Advances in molecular profiling have led to identifying four molecular subgroups of MB (WNT, SHH, Group 3, Group 4), each with distinct clinical behaviors. We hypothesize that
Externí odkaz:
https://doaj.org/article/fa3bbee293b045198feb0c616919a64e
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78442 (2013)
Engineered gene circuits offer an opportunity to harness biological systems for biotechnological and biomedical applications. However, reliance on native host promoters for the construction of circuit elements, such as logic gates, can make the imple
Externí odkaz:
https://doaj.org/article/a7e87fd512a3473790e3adf2978e35af
Autor:
Sukanya Iyer, Aamir Mir, Joel Vega-Badillo, Benjamin P. Roscoe, Raed Ibraheim, Lihua Julie Zhu, Jooyoung Lee, Pengpeng Liu, Kevin Luk, Esther Mintzer, Dongsheng Guo, Josias Soares de Brito, Charles P. Emerson, Phillip D. Zamore, Erik J. Sontheimer, Scot A. Wolfe
Publikováno v:
The CRISPR Journal. 5:685-701
While genome editing has been revolutionized by the advent of CRISPR-based nucleases, difficulties in achieving efficient, nuclease-mediated, homology-directed repair (HDR) still limit many applications. Commonly used DNA donors such as plasmids suff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2676939cee7f1aebba005624d2b76eb9
https://doi.org/10.1089/crispr.2022.0058
https://doi.org/10.1089/crispr.2022.0058
Publikováno v:
Journal of human genetics. 67(11)
Neurofibromatosis type 1 (NF1), one of the most common autosomal dominant genetic disorders, is caused by mutations in the NF1 gene. NF1 patients have a wide variety of manifestations with a subset at high risk for the development of tumors in the ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc2bebc42a9aafb3d8b6d3c6a6ef12a
https://pubmed.ncbi.nlm.nih.gov/35945271
https://pubmed.ncbi.nlm.nih.gov/35945271
Autor:
Rohan Bareja, Marwa Ismail, Douglas Martin, Ameya Nayate, Benita Tamrazi, Ralph Salloum, Ashley Margol, Alexander Judkins, Sukanya Iyer, Peter de Blank, Pallavi Tiwari
Publikováno v:
Neuro-Oncology. 24:vii185-vii186
PURPOSE Superior outcomes for medulloblastoma (MB) requires precise surgical resection which can be guided by tumor segmentation. We present the first attempt at automatic segmentation of MB tumors via a hierarchical transfer-learning model that (1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3319aae5b61e817605e6453ed947ac5d
https://doi.org/10.1093/neuonc/noac209.706
https://doi.org/10.1093/neuonc/noac209.706
Autor:
Esther Mintzer, Raed Ibraheim, Philip D. Zamore, Lihua Julie Zhu, Kevin Luk, Pengpeng Liu, Benjamin P. Roscoe, Joel Vega-Badillo, Sukanya Iyer, Josias Soares de Brito, Jooyoung Lee, Scot A. Wolfe, Aamir Mir, Erik J. Sontheimer
While genome editing has been revolutionized by the advent of CRISPR-based nucleases, difficulties in achieving efficient, nuclease-mediated, homology-directed repair (HDR) still limit many applications. Commonly used DNA donors such as plasmids suff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6931658c90b929e60e1bbceca6248635
Publikováno v:
Nature Microbiology. 3:741-748
Bacteria adapt to environmental stress by producing proteins that provide stress protection. However, stress can severely perturb the kinetics of gene expression, disrupting protein production. Here, we characterized how Escherichia coli mitigates su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87c25320bf19ac47e94cc40d371fdd3c
https://doi.org/10.1038/s41564-018-0161-3
https://doi.org/10.1038/s41564-018-0161-3
Autor:
Dongsheng Guo, Katelyn Daman, Scot A. Wolfe, Marina Zieger, Christian Mueller, Sukanya Iyer, Jennifer C. J. Chen, Charles P. Emerson, Sneha Suresh, Oliver D. King, Benjamin P. Roscoe, Pengpeng Liu, Kevin Luk
Publikováno v:
Nature
Current programmable nuclease-based methods (for example, CRISPR-Cas9) for the precise correction of a disease-causing genetic mutation harness the homology-directed repair pathway. However, this repair process requires the co-delivery of an exogenou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::914cdf521f940f269ec5749575f6d11c
https://pubmed.ncbi.nlm.nih.gov/30944467
https://pubmed.ncbi.nlm.nih.gov/30944467
Autor:
Mitchel J. Doktycz, Sukanya Iyer
Publikováno v:
ACS Synthetic Biology. 3:340-346
Realizing the potential of cell free systems will require development of ligand sensitive gene promoters that control gene expression in response to a ligand of interest. Here, we describe an approach to designing ligand sensitive transcriptional con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51db1dbae7ca9d4e62f6a8219a1e849f
https://doi.org/10.1021/sb4000756
https://doi.org/10.1021/sb4000756
Publikováno v:
Nucleic Acids Research
Synthetic biology offers great promise to a variety of applications through the forward engineering of biological function. Most efforts in this field have focused on employing living cells, yet cell-free approaches offer simpler and more flexible co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::137e3f32b4f5f4381f116af3f4becce1
https://doi.org/10.1093/nar/gkr1191
https://doi.org/10.1093/nar/gkr1191