Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sukanthini Thurairatnam"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3046-3049
This work describes the rational amelioration of mechanism-based inactivation (MBI) of Cytochrome P450 (CYP) 3A4 in a human hematopoietic prostaglandin D synthase (hH-PGDS) inhibitor (cpd 1). We utilized metabolism reports in order to check if patter
Autor:
Mark Munson, James Pribish, Lim Sungtaek, Maniar Sachin, Bradford H. Hirth, Robert H. Barker, Jiang John Z, Yong Mi Choi-Sledeski, Sukanthini Thurairatnam, Kwon Yon Musick, Elina Makino, John E. Macor
Publikováno v:
ACS Med Chem Lett
[Image: see text] Metachromatic leukodystrophy (MLD) is a rare, genetic lysosomal storage disorder caused by the deficiency of arylsulfatase A enzyme, which results in the accumulation of sulfatide in the lysosomes of the tissues of central and perip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0e9cd71be8f13535f7151488851852
https://europepmc.org/articles/PMC7549271/
https://europepmc.org/articles/PMC7549271/
Autor:
William N. Draffin, Michael G. B. Drew, Laurence M. Harwood, Estelle M.-N. Hamelin, David J. Aldous, Sukanthini Thurairatnam
Publikováno v:
Synthesis. :3271-3278
We report herein, the first generation of unsymmetrical ketone-derived chiral stabilized azomethine ylides. Intrairiolecular and intermolecular cycloaddition strategies have been utilized to synthesize both an enantiornerically pure bicyclic proline
Autor:
Sukanthini Thurairatnam, Vincent Leroy
Publikováno v:
Expert Opinion on Therapeutic Patents. 14:301-311
Cysteine proteases have attracted considerable interest over the past decade. Lysosomal cysteine protease cathepsin S plays an important role in antigen presentation and matrix degradation. Interest for this enzyme has recently grown and ~ 70 patents
Autor:
Darren Wheeler, Gary Fenton, Bamborough Paul Lindsay, Paul Joseph Cox, Sukanthini Thurairatnam, David J. Aldous, Rajesh Patel, Lai Justine Yeun Quai, Sofia Parveen, Trevor K.P. Harrison, Keith Smith, Clive Mccarthy, Shazia Sadiq, Savita Jagpal
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3111-3114
A series of oxindoles demonstrating inhibition of the phosphorylation of biotinylated substrates of Syk and IgE/FceRI triggered basophil cell degranulation has been identified. A study of the SAR around sulfonamide 31 (IC 50 =5 nM, EC 50 =1400 nM) is
Autor:
Michael G. B. Drew, Archie B. Jahans, Sukanthini Thurairatnam, Laurence M. Harwood, Estelle M.-N. Hamelin, David J. Aldous
Publikováno v:
Synlett. 2001:1836-1840
Autor:
Sukanthini, Thurairatnam
Publikováno v:
Progress in medicinal chemistry. 51
Autor:
Sukanthini Thurairatnam
Prostaglandin D2 (PGD2) is a major inflammatory mediator produced by mast cells and Th2 cells. PGD2 and its metabolites have been considered as selective markers of mast cell activation in vivo. Prostaglandin D synthases known as the lipocalin prosta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75b9dbe56e6b82a7f6def2157c3c4e81
https://doi.org/10.1016/b978-0-12-396493-9.00004-2
https://doi.org/10.1016/b978-0-12-396493-9.00004-2
Autor:
Ashton Michael John, Palfreyman Malcolm Norman, Andrew J. Ratcliffe, Sukanthini Thurairatnam, Nigel Vicker, Garry Fenton, Jan-Anders Karlsson, David Raeburn, John E. Souness, Cook David Charles
Publikováno v:
Journal of Medicinal Chemistry. 37:1696-1703
The syntheses and biological activities of a number of benzamide derivatives, designed from rolipram, which are selective inhibitors of cyclic AMP-specific phosphodiesterase (PDE IV), are described. The effects of changes to the alkoxy groups, amide
Autor:
Jan-Anders Karlsson, Andrew J. Ratcliffe, Cook David Charles, Palfreyman Malcolm Norman, Garry Fenton, Sukanthini Thurairatnam, Ashton Michael John, Nigel Vicker, John E. Souness, David Raeburn
Publikováno v:
ChemInform. 25
The syntheses and biological activities of a number of benzamide derivatives, designed from rolipram, which are selective inhibitors of cyclic AMP-specific phosphodiesterase (PDE IV), are described. The effects of changes to the alkoxy groups, amide