Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sukaina Rashid"'
Autor:
Peter W. Szlosarek, Akhila G. Wimalasingham, Melissa M. Phillips, Peter E. Hall, Pui Ying Chan, John Conibear, Louise Lim, Sukaina Rashid, Jeremy Steele, Paula Wells, Chiung‐Fang Shiu, Chih‐Ling Kuo, Xiaoxing Feng, Amanda Johnston, John Bomalaski, Stephen Ellis, Marianne Grantham, Michael Sheaff
Publikováno v:
Cancer Medicine, Vol 10, Iss 19, Pp 6642-6652 (2021)
Abstract Introduction We evaluated the arginine‐depleting enzyme pegargiminase (ADI‐PEG20; ADI) with pemetrexed (Pem) and cisplatin (Cis) (ADIPemCis) in ASS1‐deficient non‐squamous non‐small cell lung cancer (NSCLC) via a phase 1 dose‐exp
Externí odkaz:
https://doaj.org/article/fabac2ca189a4727aedc6bdbadb5864e
Autor:
Stephen Ellis, Louise Lim, Amanda Johnston, Chiung-Fang Shiu, Paula Wells, Xiaoxing Feng, Melissa Phillips, Pui Ying Chan, Sukaina Rashid, Jeremy P.C. Steele, Michael Sheaff, Marianne Grantham, John Conibear, Peter W. Szlosarek, Akhila Wimalasingham, John S. Bomalaski, Peter E Hall, Chih-Ling Kuo
Publikováno v:
Cancer Medicine, Vol 10, Iss 19, Pp 6642-6652 (2021)
Cancer Medicine
Cancer Medicine
Introduction We evaluated the arginine‐depleting enzyme pegargiminase (ADI‐PEG20; ADI) with pemetrexed (Pem) and cisplatin (Cis) (ADIPemCis) in ASS1‐deficient non‐squamous non‐small cell lung cancer (NSCLC) via a phase 1 dose‐expansion tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa686a650b84ee4f2c37da74782047b
https://doi.org/10.1002/cam4.4196
https://doi.org/10.1002/cam4.4196
Autor:
Paula Wells, M. Grant, Helen Hockings, Jubel Amin, Thomas Powles, Maria Lapuente, Bernadette Szabados, Ekaterini Boleti, Sukaina Rashid, Philip Adeniran, Rabiah Abbas Saud, Anjali Sivajothi, Shanthini M Crusz
Publikováno v:
Journal of Cancer Education
The COVID-19 pandemic has necessitated adaptation of cancer patient care. Oncology patients who contract COVID-19 have poor outcomes. Telemedicine clinics (teleclinics) have been introduced for cancer patients to reduce the risk of horizontal transmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae08c6dc0c203d93f6a0bddbd48ed06a
https://doi.org/10.1007/s13187-021-02053-8
https://doi.org/10.1007/s13187-021-02053-8
Autor:
Claude Chelala, Danilo Cucchi, Sarah A. Martin, Stuart McDonald, Jun Wang, Marc J Williams, Andrew Silver, Marta O. Freitas, Gemma Bridge, Nirosha Suraweera, Sukaina Rashid, Gyorgy Szabadkai, Zhi Yao
Publikováno v:
Cell Death and Disease, Vol 10, Iss 11, Pp 1-11 (2019)
Cell Death & Disease
Cell Death & Disease
The DNA mismatch repair (MMR) pathway is responsible for the repair of base–base mismatches and insertion/deletion loops that arise during DNA replication. MMR deficiency is currently estimated to be present in 15–17% of colorectal cancer cases a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a563068d0f6e38c21f5db1114e09a8b3
https://doi.org/10.1038/s41419-019-2018-y
https://doi.org/10.1038/s41419-019-2018-y
Publikováno v:
Cancers, Vol 6, Iss 3, Pp 1597-1614 (2014)
Cancers
Cancers
Many components of the cell, including lipids, proteins and both nuclear and mitochondrial DNA, are vulnerable to deleterious modifications caused by reactive oxygen species. If not repaired, oxidative DNA damage can lead to disease-causing mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b22da2be9f4fbadb543b65cd4890c7a
https://doi.org/10.3390/cancers6031597
https://doi.org/10.3390/cancers6031597
Autor:
Melissa Phillips, John Conibear, Simon Pacey, Michael Sheaff, Peter W. Szlosarek, Louise Lim, Jim Thomson, Xiaoxing Feng, Jeremy P.C. Steele, Pui Ying Chan, Ramsay Khadeir, Amanda Johnston, Akhila Wimalasingham, John S. Bomalaski, Peter E Hall, Sukaina Rashid, Stephen G. Ellis
Publikováno v:
Journal of Clinical Oncology. 37:9097-9097
9097 Background: Pegylated arginine deiminase (ADI-PEG20) targets ASS1-ve tumors, including non–small-cell lung cancer (NSCLC), by potentiating pemetrexed cytotoxicity via arginine depletion. In Beddowes et al (JCO 2017) we showed a 100% disease co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6eb4278dd525b81393455e3639068ab
https://doi.org/10.1200/jco.2019.37.15_suppl.9097
https://doi.org/10.1200/jco.2019.37.15_suppl.9097
Autor:
Ekaterini Boleti, Thomas Powles, Sukaina Rashid, Peter Wilson, Andrew Stockdale, Robert Jones, Simon Chowdury, Jonathan Shamash, Naveed Sarwar, Paul Nathan, Andrew Protheroe, Simon J. Crabb
Publikováno v:
European Journal of Cancer. 48:3171-3176
Both sunitinib and pazopanib are widely used as first line therapy in metastatic renal cancer (mRCC). The efficacy of these agents appears similar but they may have distinct toxicity profiles. In this study we compare the severity of symptomatic and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a9e10113205d023f0e3730dd451cf9
https://doi.org/10.1016/j.ejca.2012.05.022
https://doi.org/10.1016/j.ejca.2012.05.022
Autor:
T. Oliver, Jonathan Shamash, Laura Tookman, Thomas Powles, Sukaina Rashid, Mariam Jamal-Hanjani, Melissa Phillips, Athena Matakidou, S. J. Harland, Naveed Sarwar, Peter Wilson, Simon Chowdhury, Wendy Ansell
Publikováno v:
Acta Oncologica. 52:987-993
Objective. Metastatic seminoma is a highly curable disease. Standard treatment comprises of combination chemotherapy. The short- and long-term toxicities of this treatment are increasingly recognised and the possibility of over treatment in such a cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5591b9010d996b1e500abb751724fb98
https://doi.org/10.3109/0284186x.2012.714078
https://doi.org/10.3109/0284186x.2012.714078
Publikováno v:
Current Treatment Options in Oncology. 13:201-211
Patients with relapsed germ cell tumors (GCT) are potentially curable despite the failure of initial cisplatin based therapy. The recent identification of robust prognostic markers has helped clarify this area of uncertainly [17••]. However, unli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4834412b1cd47a1b33efacd9f2b3afca
https://doi.org/10.1007/s11864-012-0199-z
https://doi.org/10.1007/s11864-012-0199-z
Autor:
Jeremy P.C. Steele, Gary Cook, Stephen G. Ellis, Simon Pacey, John S. Bomalaski, Bor-Wen Wu, Amanda Johnston, Peter Hall, Louise Lim, John Conibear, Ramsay Khadeir, Sukaina Rashid, Melissa Phillips, Peter W. Szlosarek, Paula Wells, Xiaoxing Feng, Jim Thomson, Teresa Szyszko
Publikováno v:
Clinical Cancer Research. 24:B33-B33
Background: Loss of the metabolic tumor suppressor argininosuccinate synthetase 1 (ASS1) sensitizes non-squamous non-small cell lung cancer (NSCLC) cells to arginine deprivation with pegylated arginine deiminase (ADI-PEG20), which also disrupts thymi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4914bc7095a2c8821ab16d9da276e391
https://doi.org/10.1158/1557-3265.aacriaslc18-b33
https://doi.org/10.1158/1557-3265.aacriaslc18-b33