Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Suk Kyoon Yoon"'
Autor:
Aeri Kim, Kyungha Chung, Kim Tae-Hun, Sun-Hwa Lee, Sung-Hack Lee, Suk-Kyoon Yoon, Hee Dong Park, Jihye Lee, Seungyup Paek, Bongchan Kim, Eunice EunKyeong Kim
Publikováno v:
Molecular Pharmaceutics. 13:1197-1205
LB30870, a new direct thrombin inhibitor, showed 80% reduction in oral bioavailability in fed state. The present study aims to propose trypsin binding as a mechanism for such negative food effect and demonstrate a prodrug approach to mitigate food ef
Autor:
Yong Hyun Jeon, Sung Jin Cho, Cho Joong-Heui, Hueng-Sik Choi, Kyung-Hee Kim, Inkyu Lee, Chun Young Im, Jina Kim, Eun Kyung Yoo, Hayoung Hwang, Seoyeon Woo, Jae-Han Jeon, Seong Heon Kim, Seungyun Yoon, Hwang Hee Jong, Jungwook Chin, Suk Kyoon Yoon, Kyung-ah Seo, Jaeyoung Song, Nam Doo Kim
Publikováno v:
European journal of medicinal chemistry. 120
Estrogen-related receptor gamma (ERRγ) has recently been recognized as an attractive target for treating inflammation, cancer, and metabolic disorders. Herein, we discovered and demonstrated the in vitro pharmacology as well as the absorption, distr
Publikováno v:
Archives of pharmacal research. 38(12)
A new chimeric fusion transcript of KIF5B (the kinesin family 5B gene) and the RET (Rearranged during Transcription) oncogene, KIF5B-RET, was found in 1-2% of lung adenocarcinomas (LADCs) in 2012. Several related clinical trials for non-small cell lu
Autor:
Kwan Hyung Cho, Sung-Hack Lee, John Kim, Malcolm Boyce, Aeri Kim, Steve Warrington, Hee Dong Park, Suk Kyoon Yoon
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 45(8)
1. The safety, tolerability, pharmacokinetics, pharmacodynamics, and food effect of LB30870, a new selective thrombin inhibitor, were studied in 16 healthy men. 2. A double-blind, placebo-controlled single ascending dose study was done at oral doses
Autor:
Hee Dong Park, Su-Kyung Park, Cheol Won Park, Koo Lee, Aeri Kim, Doo-Hee Park, Kyung Ha Chung, Sang Koo Lee, Lee Sun Hwa, Suk Kyoon Yoon, Won-Hyuk Jung, Eunice E. Kim, Myung-Gyun Kang, O Hwan Kwon
Publikováno v:
Journal of Medicinal Chemistry. 46:3612-3622
Thrombin, a crucial enzyme in the blood coagulation, has been a target for antithrombotic therapy. Orally active thrombin inhibitors would provide effective and safe prophylaxis for venous and arterial thrombosis. We conducted optimization of a highl
Publikováno v:
The Journal of Organic Chemistry. 60:564-577
Autor:
Yoshito Kishi, Denice M. Spero, Keith R. Buszek, Suk Kyoon Yoon, Craig J. Forsyth, Francis G. Fang, Sun Ho Jung, Michael C. Matelich, Paul Michael Scola, Thomas Daniel Aicher
Publikováno v:
ChemInform. 23
Publikováno v:
ChemInform. 26
Autor:
Yoshito Kishi, Suk Kyoon Yoon, Keith R. Buszek, Craig J. Forsyth, Scola Paula M, Francis G. Fang, Sung Ho Jung
Publikováno v:
Tetrahedron Letters. 33:1553-1556
Autor:
Thomas Daniel Aicher, Keith R. Buszek, Craig J. Forsyth, Suk Kyoon Yoon, Francis G. Fang, Michael C. Matelich, Denice M. Spero, Paul Michael Scola, Yoshito Kishi, Sun Ho Jung
Publikováno v:
Journal of the American Chemical Society. 114:3162-3164