Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sujith V.W. Weerasinghe"'
Autor:
Raymond Kwan, Lu Chen, Min-Jung Park, Zemin Su, Sujith V.W. Weerasinghe, William M. Lee, Valerie L. Durkalski-Mauldin, Robert J. Fontana, M Bishr Omary
Publikováno v:
Clinical Gastroenterology and Hepatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85692d7d96dffef44b013260a22d9e19
https://doi.org/10.1016/j.cgh.2023.03.002
https://doi.org/10.1016/j.cgh.2023.03.002
Autor:
Xin Tong, Lei Yin, Ram K. Menon, Colin L. Stewart, Min-Jung Park, Makayla J. Brunt, M. Bishr Omary, Raymond Kwan, Maria Brzozowski, Graham F. Brady, Sujith V.W. Weerasinghe, Hope Martin
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 4, Iss 3, Pp 365-383 (2017)
Cellular and Molecular Gastroenterology and Hepatology, Vol 4, Iss 3, Pp 365-383 (2017)
Background & Aims Lamins are nuclear intermediate filament proteins that comprise the major components of the nuclear lamina. Mutations in LMNA, which encodes lamins A/C, cause laminopathies, including lipodystrophy, cardiomyopathy, and premature agi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60446073e37b69f0d71e80d0e0991cc
https://doi.org/10.1016/j.jcmgh.2017.06.005
https://doi.org/10.1016/j.jcmgh.2017.06.005
Publikováno v:
Molecular Biology of the Cell
Mouse strain–dependent selective loss of apoptosis enzymes, with consequent decrease in susceptibility to apoptosis, occurs upon short-term hepatocyte culture and in vivo. These susceptibility differences likely reflect genetic modifiers that provi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3718ff6d5befb2e30ea35ed90fca5d7
https://doi.org/10.1091/mbc.e15-06-0423
https://doi.org/10.1091/mbc.e15-06-0423
Publikováno v:
Archiv der Pharmazie. 349:373-382
Histone deacetylase (HDAC) proteins have emerged as targets for anti-cancer therapeutics, with several inhibitors used in the clinic, including suberoylanilide hydroxamic acid (SAHA, vorinostat). Because SAHA and many other inhibitors target all or m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9467237211ee5e9f07387cb9b6763443
https://doi.org/10.1002/ardp.201500472
https://doi.org/10.1002/ardp.201500472
Carbamoyl phosphate synthetase-1 is a rapid turnover biomarker in mouse and human acute liver injury
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 307:G355-G364
Several serum markers are used to assess hepatocyte damage, but they have limitations related to etiology specificity and prognostication. Identification of novel hepatocyte-specific biomarkers could provide important prognostic information and bette
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4eb7d6a7b9ed9a26c6931238a3c654
https://doi.org/10.1152/ajpgi.00303.2013
https://doi.org/10.1152/ajpgi.00303.2013
Autor:
Jessica M. Leonard, Natasha T. Snider, M. Bishr Omary, Anna S. Lok, Amika Singla, Shinichiro Hanada, Philip C. Andrews, Sujith V.W. Weerasinghe
Publikováno v:
The Journal of Cell Biology
Differential expression and activity of the cellular energy regulators GAPDH and NDPK underlie reactive oxygen species–induced damage in the mouse liver and may contribute to human liver disease progression.
Genetic factors impact liver injury
Genetic factors impact liver injury
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46dd1c9e67e611f9f2cfa73e94809d10
http://europepmc.org/articles/PMC3198167
http://europepmc.org/articles/PMC3198167
Autor:
Guo Zhong Tao, Qing Xie, Sujith V.W. Weerasinghe, M. Bishr Omary, Raymond Kwan, Robert S. Adelstein, Natasha T. Snider, Lu Chen, Mary Anne Conti, Koksun Looi
Publikováno v:
Hepatology (Baltimore, Md.). 62(6)
Keratins, among other cytoskeletal intermediate filament proteins, are mutated at a highly conserved arginine with consequent severe disease phenotypes due to disruption of keratin filament organization. We screened a kinase inhibitor library, using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8d23510e6b9c5d38e6e651909c18d8
https://pubmed.ncbi.nlm.nih.gov/26387879
https://pubmed.ncbi.nlm.nih.gov/26387879
Publikováno v:
Journal of Cell Science.
Keratin 18 (K18 or KRT18) undergoes caspase-mediated cleavage during apoptosis, the significance of which is poorly understood. Here, we mutated the two caspase-cleavage sites (D238E and D397E) in K18 (K18-DE), followed by transgenic overexpression o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0adbe2301d563d429e2e51aca53b67f4
https://doi.org/10.1242/jcs.138479
https://doi.org/10.1242/jcs.138479
Publikováno v:
Gastroenterology. 150:S1029
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7557822b165ec855afa5966d72f8b5c
https://doi.org/10.1016/s0016-5085(16)33484-9
https://doi.org/10.1016/s0016-5085(16)33484-9
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(20)
The FDA-approved drug suberoylanilide hydroxamic acid (SAHA, Vorinostat) was modified to improve its selectivity for a single histone deaetylase (HDAC) isoform. We show that attaching an ethyl group at the C3 position transforms SAHA from non-selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a83f1f762dda4399e9a0a670c0a991de
https://pubmed.ncbi.nlm.nih.gov/21889343
https://pubmed.ncbi.nlm.nih.gov/21889343