Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sujatha Manthri"'
Autor:
Andrea Nühs, Manu De Rycker, Sujatha Manthri, Eamon Comer, Christina A Scherer, Stuart L Schreiber, Jean-Robert Ioset, David W Gray
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 9, p e0004094 (2015)
Visceral leishmaniasis is an important parasitic disease of the developing world with a limited arsenal of drugs available for treatment. The existing drugs have significant deficiencies so there is an urgent need for new and improved drugs. In the h
Externí odkaz:
https://doaj.org/article/cd8f4a6be22a43ea90005eb819ad4238
Autor:
Caterina Pont, Elisabet Viayna, Stephen Brand, Ian H. Gilbert, Peter George Dodd, Iva Lukac, Laste Stojanovski, Maria Osuna-Cabello, Jennifer Riley, Sujatha Manthri, Kate McGonagle, Timothy J. Miles, Julio Martin, Fabio Zuccotto, Frederick R. C. Simeons, John Thomas, Maria L. Marco, Paul G. Wyatt, Kevin D. Read, Stephen Thompson, Jose M. Fiandor, Michael G. Thomas, Manu De Rycker, Eun-Jung Ko
Publikováno v:
Journal of Medicinal Chemistry
There is an urgent need for new treatments for visceral leishmaniasis (VL), a parasitic infection which impacts heavily large areas of East Africa, Asia, and South America. We previously reported on the discovery of GSK3494245/DDD01305143 (1) as a pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023548cc95d4d9c556b1402e19227eb9
http://europepmc.org/articles/PMC8154566
http://europepmc.org/articles/PMC8154566
Autor:
Michael G. Thomas, Maria L. Marco, John Thomas, Daniel Spinks, Ian H. Gilbert, Laste Stojanovski, Frederick R. C. Simeons, Ola Epemolu, Sujatha Manthri, Claire Naylor, Timothy J. Miles, Manu De Rycker, Suzanne Norval, Susan Wyllie, Stephen Patterson, Jennifer Riley, Maria Osuna-Cabello, Richard J. Wall, Jose M. Fiandor, Paul G. Wyatt, Kevin D. Read, Stephen Thompson
Publikováno v:
Journal of Medicinal Chemistry. 63:9523-9539
Visceral leishmaniasis (VL) is a parasitic infection that results in approximately 26 000–65 000 deaths annually. The available treatments are hampered by issues such as toxicity, variable efficacy...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2075363d9d5006cac4eca5979afbbe9
https://doi.org/10.1021/acs.jmedchem.0c00705
https://doi.org/10.1021/acs.jmedchem.0c00705
Autor:
Ian H. Gilbert, Sandra Carvalho, Stephen Thompson, Lorna MacLean, Fabio Zuccotto, Susan Wyllie, Timothy J. Miles, Lalitha Sastry, Ignacio Cotillo, Manu De Rycker, Juan A. Bueren-Calabuig, Sonia Moniz, Rachel Milne, Albane Kessler, Maria L. Marco, Julio Martin, Richard J. Wall, Alan H. Fairlamb, Juan Cantizani-Perez, Michael G. Thomas, Stephen Patterson, Sujatha Manthri
Publikováno v:
ACS Infectious Diseases
Available treatments for Chagas' disease and visceral leishmaniasis are inadequate, and there is a pressing need for new therapeutics. Drug discovery efforts for both diseases principally rely upon phenotypic screening. However, the optimization of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbdbdb72ed0d785ae1f89aec7a44bf2
http://europepmc.org/articles/PMC7076694
http://europepmc.org/articles/PMC7076694
Autor:
Kevin D. Read, Sabrinia D. Crouch, Juan Miguel-Siles, Stephen Thompson, Lorna MacLean, Timothy J. Miles, Franck Martin, Alain Claude-Marie Daugan, Suzanne Norval, Laste Stojanovski, Gloria Fra, John Thomas, Frederick R. C. Simeons, Sujatha Manthri, Jose M. Fiandor, César Guerrero, Myriam Ajakane, Maria Osuna-Cabello, Paul G. Wyatt, Manu De Rycker, Lorna Campbell, Claire J. MacKenzie, Ian H. Gilbert, Jennifer Riley, Yoko Shishikura, Michael G. Thomas, Raul F. Velasco
Publikováno v:
RSC Medicinal Chemistry. 11:1168-1177
Visceral leishmaniasis (VL) affects millions of people across the world, largely in developing nations. It is fatal if left untreated and the current treatments are inadequate. As such, there is an urgent need for new, improved medicines. In this pap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::907889087930243eaf8e578bd0ada172
https://doi.org/10.1039/d0md00203h
https://doi.org/10.1039/d0md00203h
Autor:
Louise A. Walker, Ali Floyd, Nicola R. Stanley-Wall, Margarita Kalamara, Sarah J. Coulthurst, Karen Stephenson, Geoffrey M. Gadd, Chih-Yu Hsu, Marina Fomina, John Thomas, Megan Bergkessel, Manu De Rycker, Amy Cameron, Ailsa Mackintosh, Lewis Houghton, Thibault Rosazza, Xia Kang, Saria Mansoor, Erin Hardee, Sujatha Manthri, Helge C. Dorfmueller
Here you will find a series of images taken by scientists based at the University of Dundee that highlight the microbes they work with. The images in the collection are part of a physical exhibition located at the Dundee Science Centre.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a608ef55c8751ed6350a71425e8e92bd
https://doi.org/10.20933/100001214
https://doi.org/10.20933/100001214
Autor:
Lorna MacLean, Rod J. Dillon, Ali Floyd, Sujatha Manthri, Sarah Cook, Nina Svensen, David Horn, Lalitha Shastry, Holly Yeoman, Michael A. J. Ferguson, Alan R. Prescott, Christy Paterson, Alan H. Fairlamb, Lesley Pearson, Jen Southern, John Thomas, Kevin D. Read
What does lifespan mean for a parasite that reproduces as asexual clones and is revived after 30 years suspended in a deep frozen state? How far does the digital footprint of a parasite stretch online? This work centers on the deadly Leishmania paras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22289aa4ef7b74e3bdc873e438349fab
https://doi.org/10.20933/100001171
https://doi.org/10.20933/100001171
Autor:
Victoriano, Corpas-Lopez, Sonia, Moniz, Michael, Thomas, Richard J, Wall, Leah S, Torrie, Dorothea, Zander-Dinse, Michele, Tinti, Stephen, Brand, Laste, Stojanovski, Sujatha, Manthri, Irene, Hallyburton, Fabio, Zuccotto, Paul G, Wyatt, Manu, De Rycker, David, Horn, Michael A J, Ferguson, Joachim, Clos, Kevin D, Read, Alan H, Fairlamb, Ian H, Gilbert, Susan, Wyllie
Publikováno v:
ACS Infectious Diseases
Visceral leishmaniasis (VL), caused by the protozoan parasites Leishmania donovani and L. infantum, is responsible for ∼30 000 deaths annually. Available treatments are inadequate, and there is a pressing need for new therapeutics. N-Myristoyltrans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d042f2cce6e2218071c03684d8874664
https://pubmed.ncbi.nlm.nih.gov/30380837
https://pubmed.ncbi.nlm.nih.gov/30380837
Autor:
Leah S, Torrie, Stephen, Brand, David A, Robinson, Eun Jung, Ko, Laste, Stojanovski, Frederick R C, Simeons, Susan, Wyllie, John, Thomas, Lucy, Ellis, Maria, Osuna-Cabello, Ola, Epemolu, Andrea, Nühs, Jennifer, Riley, Lorna, MacLean, Sujatha, Manthri, Kevin D, Read, Ian H, Gilbert, Alan H, Fairlamb, Manu, De Rycker
Publikováno v:
ACS Infectious Diseases
Methionyl-tRNA synthetase (MetRS) has been chemically validated as a drug target in the kinetoplastid parasite Trypanosoma brucei. In the present study, we investigate the validity of this target in the related trypanosomatid Leishmania donovani. Fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8857ac374ff4cc86c9c9d657faf2cfba
https://pubmed.ncbi.nlm.nih.gov/28967262
https://pubmed.ncbi.nlm.nih.gov/28967262
Autor:
Stephanie Gresham, Stephen Patterson, Laste Stojanovski, Fabio Zuccotto, Susan Wyllie, Matthew Berriman, Timothy J. Miles, Frederick R. C. Simeons, Nadine Homeyer, Lorna MacLean, Paul Connolly, Lalitha Sastry, Manu De Rycker, Rhiannon Lowe, Gerard Drewes, Sabrinia D. Crouch, David W. Gray, Thomas D. Otto, Sebastian Albrecht, Michael G. Thomas, Michael A. J. Ferguson, Sujatha Manthri, Michael D. Urbaniak, Markus Boesche, Hannah Pflaumer, Alan H. Fairlamb, Ian H. Gilbert, Sonja Ghidelli-Disse, Kevin D. Read, Paul G. Wyatt, Jose M. Fiandor, Susan Dixon
Publikováno v:
Nature
Visceral leishmaniasis causes considerable mortality and morbidity in many parts of the world. There is an urgent need for the development of new, effective treatments for this disease. Here we describe the development of an anti-leishmanial drug-lik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6f9bff9da702dd0f4d789ce1ce05a4
https://pubmed.ncbi.nlm.nih.gov/30076375
https://pubmed.ncbi.nlm.nih.gov/30076375