Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Sujatha Kannan"'
Autor:
Anjali Sharma, Nirnath Sah, Rishi Sharma, Preeti Vyas, Wathsala Liyanage, Sujatha Kannan, Rangaramanujam M. Kannan
Publikováno v:
Bioengineering & Translational Medicine, Vol 9, Iss 5, Pp n/a-n/a (2024)
Abstract Neuronal hyperexcitability and excitotoxicity lies at the core of debilitating brain disorders such as epilepsy and traumatic brain injury, culminating in neuronal death and compromised brain function. Overcoming this challenge requires a un
Externí odkaz:
https://doaj.org/article/09199a3c721b456693d04ef1452a24de
Autor:
Quentin Raas, Austin Wood, Tamara J. Stevenson, Shanna Swartwood, Suzanne Liu, Rangaramanujam M. Kannan, Sujatha Kannan, Joshua L. Bonkowsky
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
BackgroundMitchell syndrome is a rare, neurodegenerative disease caused by an ACOX1 gain-of-function mutation (c.710A>G; p.N237S), with fewer than 20 reported cases. Affected patients present with leukodystrophy, seizures, and hearing loss. ACOX1 ser
Externí odkaz:
https://doaj.org/article/bf6d5882622a4b7e9b5b2ce577e8e0b1
Autor:
Joshua E. Porterfield, Rishi Sharma, Ambar Scarlet Jimenez, Nirnath Sah, Sean McCracken, Lucia Zhang, Hyoung‐Tae An, Seulki Lee, Sujatha Kannan, Anjali Sharma, Rangaramanujam M. Kannan
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 3, Pp n/a-n/a (2023)
Abstract Toxicity to hepatocytes caused by various insults including drugs is a common cause of chronic liver failure requiring transplantation. Targeting therapeutics specifically to hepatocytes is often a challenge since they are relatively nonendo
Externí odkaz:
https://doaj.org/article/ce6ab5d58d304ee1a6751309fa7d35f2
Autor:
Zhi Zhang, Yi-An Lin, Soo-Young Kim, Lilly Su, Jinhuan Liu, Rangaramanujam M. Kannan, Sujatha Kannan
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
Abstract Background Neuroinflammation mediated by microglia plays a central role in the pathogenesis of perinatal/neonatal brain injury, including cerebral palsy (CP). Therapeutics mitigating neuroinflammation potentially provide an effective strateg
Externí odkaz:
https://doaj.org/article/dcd390a667b74e2cb4d8076ade130fa4
Autor:
Hiren R. Modi, Qihong Wang, Sarah J. Olmstead, Elizabeth S. Khoury, Nirnath Sah, Yu Guo, Payam Gharibani, Rishi Sharma, Rangaramanujam M. Kannan, Sujatha Kannan, Nitish V. Thakor
Publikováno v:
Bioengineering & Translational Medicine, Vol 7, Iss 1, Pp n/a-n/a (2022)
Abstract Cardiac arrest (CA), the sudden cessation of effective cardiac pumping function, is still a major clinical problem with a high rate of early and long‐term mortality. Post‐cardiac arrest syndrome (PCAS) may be related to an early systemic
Externí odkaz:
https://doaj.org/article/e86dd8cd506a40f1a0848a7d71a8bdc2
Autor:
Yang Liu, Quan Na, Jin Liu, Anguo Liu, Akosua Oppong, Ji Yeon Lee, Anna Chudnovets, Jun Lei, Rishi Sharma, Sujatha Kannan, Rangaramanujam M. Kannan, Irina Burd
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Intrauterine inflammation (IUI) is the primary cause of spontaneous preterm birth and predisposes neonates to long-term sequelae, including adverse neurological outcomes. N-acetyl-L-cysteine (NAC) is the amino acid L-cysteine derivative and a precurs
Externí odkaz:
https://doaj.org/article/0c23432a343a4870b6bbcac44c977aa4
Autor:
Aria C Shi, Elizabeth S Khoury, Nirnath Sah, Amanda Fowler, Kevin Liaw, Anjali Sharma, Rangaramanujam M. Kannan, Sujatha Kannan
Publikováno v:
Precision Nanomedicine, Vol 4, Iss 4 (2021)
Hydroxyl dendrimers target reactive microglia in multiple neuroinflammatory models, including cerebral palsy. Insights on the differential uptake of dendrimers between subpopulations of micro-glia will enable the better design of precise nanomedicine
Externí odkaz:
https://doaj.org/article/90024bdc96c24bcbad7e6746e43df096
Autor:
Carolyn Tallon, Benjamin J. Bell, Anjali Sharma, Arindom Pal, Medhinee M. Malvankar, Ajit G. Thomas, Seung-Wan Yoo, Kristen R. Hollinger, Kaleem Coleman, Elizabeth L. Wilkinson, Sujatha Kannan, Norman J. Haughey, Rangaramanujam M. Kannan, Rana Rais, Barbara S. Slusher
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2066 (2022)
Alzheimer’s disease (AD) is characterized by the progressive accumulation of amyloid-β and hyperphosphorylated tau (pTau), which can spread throughout the brain via extracellular vesicles (EVs). Membrane ceramide enrichment regulated by the enzyme
Externí odkaz:
https://doaj.org/article/5393689d5ecd4b8598d99f7d3e2fafda
Autor:
Kevin Liaw, Rajsekhar Reddy, Anjali Sharma, Jiangyu Li, Michelle Chang, Rishi Sharma, Sebastian Salazar, Sujatha Kannan, Rangaramanujam M. Kannan
Publikováno v:
Bioengineering & Translational Medicine, Vol 6, Iss 2, Pp n/a-n/a (2021)
Abstract Glioblastoma is the most common and aggressive form of primary brain cancer, with median survival of 16–20 months and a 5‐year survival rates of
Externí odkaz:
https://doaj.org/article/d01b3f9afa4447f69a08063ec4f91143
Autor:
Philip A. Verhoef, MD, PhD, Sujatha Kannan, MD, Jamie L. Sturgill, PhD, Elizabeth W. Tucker, MD, Peter E. Morris, MD, Andrew C. Miller, MD, Travis R. Sexton, PhD, Jay L. Koyner, MD, Rana Hejal, MD, Scott C. Brakenridge, MD, Lyle L. Moldawer, PhD, Richard S. Hotchkiss, MD, Teresa M. Blood, BS, Monty B. Mazer, MD, Scott Bolesta, PharmD, Sheila A. Alexander, PhD, RN, Donna Lee Armaignac, PhD, Steven L. Shein, MD, Christopher Jones, MD, Caroline D. Hoemann, PhD, Allan Doctor, MD, Stuart H. Friess, MD, Robert I. Parker, MD, Alexandre T. Rotta, MD, Kenneth E. Remy, MD, MHSC, MSCI, for the Basic and Translational Science Committee of the Research Section for the Society of Critical Care Medicine
Publikováno v:
Critical Care Explorations, Vol 3, Iss 3, p e0374 (2021)
Objectives:. Since the beginning of the coronavirus disease 2019 pandemic, hundreds of thousands of patients have been treated in ICUs across the globe. The severe acute respiratory syndrome–associated coronavirus 2 virus enters cells via the angio
Externí odkaz:
https://doaj.org/article/c5f76a3109294d45a95f3597c6062c88